Motif ID: Dlx5_Dlx4

Z-value: 1.320

Transcription factors associated with Dlx5_Dlx4:

Gene SymbolEntrez IDGene Name
Dlx4 ENSMUSG00000020871.7 Dlx4
Dlx5 ENSMUSG00000029755.9 Dlx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx5mm10_v2_chr6_-_6882068_68820920.133.4e-01Click!


Activity profile for motif Dlx5_Dlx4.

activity profile for motif Dlx5_Dlx4


Sorted Z-values histogram for motif Dlx5_Dlx4

Sorted Z-values for motif Dlx5_Dlx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx5_Dlx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_84417359 13.094 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr9_-_16378231 7.649 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chrM_+_10167 7.311 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chrM_+_9870 6.882 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr1_-_24612700 5.779 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr11_+_58948890 5.744 ENSMUST00000078267.3
 Hist3h2ba
histone cluster 3, H2ba
chr5_+_139543889 5.606 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr15_-_81843699 5.533 ENSMUST00000092020.2
 Gm8444
predicted gene 8444
chrX_-_143933204 5.033 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr9_-_66514567 4.617 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr7_+_51621830 4.610 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr16_-_45724600 4.311 ENSMUST00000096057.4
 Tagln3
transgelin 3
chr16_+_52031549 4.279 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr4_-_20778527 4.234 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3
chr18_+_69346143 4.189 ENSMUST00000114980.1
 Tcf4
transcription factor 4
chr5_+_17574268 4.145 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chrX_-_143933089 4.011 ENSMUST00000087313.3
 Dcx
doublecortin
chr12_-_55014329 3.866 ENSMUST00000172875.1
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chr7_-_25882407 3.833 ENSMUST00000163316.2
 Gm6434
predicted gene 6434
chr3_-_19264959 3.799 ENSMUST00000121951.1
 Pde7a
phosphodiesterase 7A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 13.1 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.4 9.4 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.5 9.0 GO:0021860 pyramidal neuron development(GO:0021860)
0.6 8.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 8.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 7.7 GO:0010842 retina layer formation(GO:0010842)
1.1 7.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.9 7.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 6.8 GO:0006342 chromatin silencing(GO:0006342)
0.2 6.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 5.9 GO:0006334 nucleosome assembly(GO:0006334)
0.2 5.3 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.3 4.6 GO:0001504 neurotransmitter uptake(GO:0001504)
1.4 4.3 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.4 4.2 GO:0042118 endothelial cell activation(GO:0042118)
0.4 4.0 GO:0030035 microspike assembly(GO:0030035)
0.4 3.8 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.1 3.8 GO:0019228 neuronal action potential(GO:0019228)
0.1 3.7 GO:0007608 sensory perception of smell(GO:0007608)
0.0 3.7 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.3 GO:0070469 respiratory chain(GO:0070469)
0.4 14.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 13.5 GO:0030425 dendrite(GO:0030425)
0.1 9.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 7.2 GO:0000790 nuclear chromatin(GO:0000790)
0.1 4.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 4.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 4.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.8 3.9 GO:0008623 CHRAC(GO:0008623)
0.0 3.5 GO:0043198 dendritic shaft(GO:0043198)
0.7 3.4 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 3.2 GO:0005844 polysome(GO:0005844)
0.0 3.1 GO:0043195 terminal bouton(GO:0043195)
0.1 3.0 GO:0000786 nucleosome(GO:0000786)
0.0 3.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 2.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 2.8 GO:1990391 DNA repair complex(GO:1990391)
0.1 2.7 GO:0001741 XY body(GO:0001741)
0.1 2.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.6 GO:0045211 postsynaptic membrane(GO:0045211)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 18.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.6 13.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.4 9.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 8.5 GO:0042393 histone binding(GO:0042393)
0.1 6.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 6.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.5 5.9 GO:0038191 neuropilin binding(GO:0038191)
0.0 5.5 GO:0061659 ubiquitin-like protein ligase activity(GO:0061659)
0.2 4.3 GO:0001784 phosphotyrosine binding(GO:0001784)
1.0 4.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.6 3.7 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 3.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 3.3 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.1 3.2 GO:0031489 myosin V binding(GO:0031489)
1.0 3.1 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.0 3.0 GO:0044325 ion channel binding(GO:0044325)
0.2 2.9 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.2 2.9 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 2.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.4 2.7 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)