Motif ID: E2f1

Z-value: 5.662


Transcription factors associated with E2f1:

Gene SymbolEntrez IDGene Name
E2f1 ENSMUSG00000027490.11 E2f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f1mm10_v2_chr2_-_154569720_1545697990.876.6e-19Click!


Activity profile for motif E2f1.

activity profile for motif E2f1


Sorted Z-values histogram for motif E2f1

Sorted Z-values for motif E2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_120476469 50.788 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr15_-_98004695 48.464 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chrX_-_60893430 46.726 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr15_-_98004634 43.647 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr17_+_56303396 42.568 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr17_+_56303321 39.819 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr1_-_20820213 38.541 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr14_-_47276790 38.225 ENSMUST00000111792.1
ENSMUST00000111791.1
ENSMUST00000111790.1
 Wdhd1


WD repeat and HMG-box DNA binding protein 1


chr11_+_98907801 35.868 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr7_+_13278778 34.735 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
 Lig1


ligase I, DNA, ATP-dependent


chr12_+_8771317 34.105 ENSMUST00000020911.7
 Sdc1
syndecan 1
chr16_+_93883895 33.765 ENSMUST00000023666.4
ENSMUST00000117099.1
ENSMUST00000142316.1
 Chaf1b


chromatin assembly factor 1, subunit B (p60)


chr12_+_24708241 33.729 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr2_+_163054682 33.559 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr11_+_119022962 32.908 ENSMUST00000026662.7
 Cbx2
chromobox 2
chr7_+_102441685 32.682 ENSMUST00000033283.9
 Rrm1
ribonucleotide reductase M1
chr10_-_128704978 31.562 ENSMUST00000026416.7
ENSMUST00000026415.7
 Cdk2

cyclin-dependent kinase 2

chr12_+_8771405 31.281 ENSMUST00000171158.1
 Sdc1
syndecan 1
chr7_+_65862029 29.315 ENSMUST00000055576.5
ENSMUST00000098391.4
 Pcsk6

proprotein convertase subtilisin/kexin type 6

chr15_+_55557399 29.037 ENSMUST00000022998.7
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 539 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.2 271.7 GO:0006270 DNA replication initiation(GO:0006270)
8.1 121.3 GO:0010216 maintenance of DNA methylation(GO:0010216)
11.7 105.7 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
6.6 104.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 95.9 GO:0006260 DNA replication(GO:0006260)
19.2 76.9 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
14.2 71.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
13.1 65.4 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
2.6 58.7 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
19.2 57.6 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
4.8 57.1 GO:0007076 mitotic chromosome condensation(GO:0007076)
2.1 56.1 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
18.5 55.5 GO:0072180 mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
7.6 52.9 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
2.5 50.0 GO:0040034 regulation of development, heterochronic(GO:0040034)
6.8 47.6 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
5.8 46.6 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
3.9 46.4 GO:0019985 translesion synthesis(GO:0019985)
5.0 44.6 GO:0060613 fat pad development(GO:0060613)
3.3 43.4 GO:0034501 protein localization to kinetochore(GO:0034501)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 230 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 710.7 GO:0005634 nucleus(GO:0005634)
2.8 191.9 GO:0005657 replication fork(GO:0005657)
11.4 170.3 GO:0042555 MCM complex(GO:0042555)
0.4 133.5 GO:0005667 transcription factor complex(GO:0005667)
0.8 133.0 GO:0000775 chromosome, centromeric region(GO:0000775)
0.2 102.4 GO:0005694 chromosome(GO:0005694)
7.4 96.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
17.5 87.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.4 69.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.8 64.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
7.9 63.5 GO:0098536 deuterosome(GO:0098536)
0.8 62.1 GO:0005814 centriole(GO:0005814)
5.3 52.7 GO:0000805 X chromosome(GO:0000805)
1.2 51.5 GO:0034707 chloride channel complex(GO:0034707)
0.8 50.5 GO:0005844 polysome(GO:0005844)
8.1 48.8 GO:0005663 DNA replication factor C complex(GO:0005663)
15.7 47.2 GO:0033186 CAF-1 complex(GO:0033186)
1.4 45.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.9 41.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
2.3 39.6 GO:0035098 ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 334 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 175.9 GO:0042393 histone binding(GO:0042393)
2.4 140.6 GO:0003678 DNA helicase activity(GO:0003678)
0.7 127.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 100.9 GO:0003723 RNA binding(GO:0003723)
0.4 98.6 GO:0008022 protein C-terminus binding(GO:0008022)
0.9 96.2 GO:0004386 helicase activity(GO:0004386)
31.6 94.7 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
6.1 92.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
17.5 87.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.3 87.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.3 87.2 GO:0003682 chromatin binding(GO:0003682)
1.9 80.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
6.0 65.7 GO:0003680 AT DNA binding(GO:0003680)
5.8 64.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
2.1 61.2 GO:0017025 TBP-class protein binding(GO:0017025)
1.6 59.3 GO:0070063 RNA polymerase binding(GO:0070063)
8.8 52.8 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.3 51.6 GO:0008536 Ran GTPase binding(GO:0008536)
2.6 51.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
1.3 46.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)