Motif ID: E2f2_E2f5

Z-value: 4.060

Transcription factors associated with E2f2_E2f5:

Gene SymbolEntrez IDGene Name
E2f2 ENSMUSG00000018983.9 E2f2
E2f5 ENSMUSG00000027552.8 E2f5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f2mm10_v2_chr4_+_136172367_1361723950.933.0e-27Click!
E2f5mm10_v2_chr3_+_14578609_145786870.804.7e-14Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of E2f2_E2f5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_136172367 52.069 ENSMUST00000061721.5
E2f2
E2F transcription factor 2
chr5_+_139543889 51.813 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr2_-_157204483 50.599 ENSMUST00000029170.7
Rbl1
retinoblastoma-like 1 (p107)
chr12_+_24708241 38.534 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr17_+_56304313 37.451 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr13_-_24761861 37.315 ENSMUST00000006898.3
ENSMUST00000110382.2
Gmnn

geminin

chr13_-_24761440 36.912 ENSMUST00000176890.1
ENSMUST00000175689.1
Gmnn

geminin

chr4_+_126556935 35.835 ENSMUST00000048391.8
Clspn
claspin
chr7_-_137314394 35.302 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr10_+_110745433 34.100 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
E2f7



E2F transcription factor 7



chr6_+_4747306 33.478 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
Peg10


paternally expressed 10


chr8_+_75109528 32.803 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr4_+_126556994 31.544 ENSMUST00000147675.1
Clspn
claspin
chr10_-_69352886 31.236 ENSMUST00000119827.1
ENSMUST00000020099.5
Cdk1

cyclin-dependent kinase 1

chr9_+_122951051 30.484 ENSMUST00000040717.5
Kif15
kinesin family member 15
chr2_-_113848655 29.812 ENSMUST00000102545.1
ENSMUST00000110948.1
Arhgap11a

Rho GTPase activating protein 11A

chr15_-_58135047 28.715 ENSMUST00000038194.3
Atad2
ATPase family, AAA domain containing 2
chr13_+_92354783 28.691 ENSMUST00000022218.4
Dhfr
dihydrofolate reductase
chr2_-_113848601 28.209 ENSMUST00000110949.2
Arhgap11a
Rho GTPase activating protein 11A
chr2_+_119112793 28.146 ENSMUST00000140939.1
ENSMUST00000028795.3
Rad51

RAD51 homolog

chr10_-_5805412 27.828 ENSMUST00000019907.7
Fbxo5
F-box protein 5
chr10_-_60219260 27.798 ENSMUST00000135158.2
Chst3
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
chr1_-_20820213 27.487 ENSMUST00000053266.9
Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr15_-_9140374 27.258 ENSMUST00000096482.3
ENSMUST00000110585.2
Skp2

S-phase kinase-associated protein 2 (p45)

chr1_-_128359610 25.244 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr15_-_55090422 24.992 ENSMUST00000110231.1
ENSMUST00000023059.6
Dscc1

defective in sister chromatid cohesion 1 homolog (S. cerevisiae)

chr2_+_72476159 23.484 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr12_-_69228167 23.114 ENSMUST00000021359.5
Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr4_+_115000156 22.902 ENSMUST00000030490.6
Stil
Scl/Tal1 interrupting locus
chrX_-_93632113 22.800 ENSMUST00000006856.2
Pola1
polymerase (DNA directed), alpha 1
chr2_+_132816141 22.168 ENSMUST00000028831.8
ENSMUST00000066559.5
Mcm8

minichromosome maintenance deficient 8 (S. cerevisiae)

chr14_-_31019055 22.146 ENSMUST00000037739.6
Gnl3
guanine nucleotide binding protein-like 3 (nucleolar)
chr5_+_114130386 22.010 ENSMUST00000031587.6
Ung
uracil DNA glycosylase
chr2_+_72476225 21.645 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chrX_-_51205773 21.628 ENSMUST00000114875.1
Mbnl3
muscleblind-like 3 (Drosophila)
chr6_-_88898664 21.051 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr12_+_24708984 20.648 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr4_+_115000174 20.519 ENSMUST00000129957.1
Stil
Scl/Tal1 interrupting locus
chr9_+_64281575 20.220 ENSMUST00000034964.6
Tipin
timeless interacting protein
chr7_-_48881032 18.898 ENSMUST00000058745.8
E2f8
E2F transcription factor 8
chr1_-_191575534 18.823 ENSMUST00000027933.5
Dtl
denticleless homolog (Drosophila)
chr11_+_80089385 17.757 ENSMUST00000108239.1
ENSMUST00000017694.5
Atad5

ATPase family, AAA domain containing 5

chr13_-_64153194 17.724 ENSMUST00000059817.4
ENSMUST00000117241.1
Zfp367

zinc finger protein 367

chrX_+_42151002 17.052 ENSMUST00000123245.1
Stag2
stromal antigen 2
chr7_+_110122299 16.977 ENSMUST00000033326.8
Wee1
WEE 1 homolog 1 (S. pombe)
chr12_-_11265768 16.611 ENSMUST00000166117.1
Gen1
Gen homolog 1, endonuclease (Drosophila)
chr7_-_48881596 16.535 ENSMUST00000119223.1
E2f8
E2F transcription factor 8
chr17_+_56303396 16.407 ENSMUST00000113038.1
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr14_-_20388822 16.082 ENSMUST00000022345.6
Dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr13_-_55329723 15.854 ENSMUST00000021941.7
Mxd3
Max dimerization protein 3
chrX_-_51205990 15.344 ENSMUST00000114876.2
Mbnl3
muscleblind-like 3 (Drosophila)
chr3_-_95217877 14.726 ENSMUST00000136139.1
Gabpb2
GA repeat binding protein, beta 2
chr5_+_110286306 14.537 ENSMUST00000007296.5
ENSMUST00000112482.1
Pole

polymerase (DNA directed), epsilon

chr9_+_65630552 14.498 ENSMUST00000055844.8
Rbpms2
RNA binding protein with multiple splicing 2
chr3_-_95217690 14.468 ENSMUST00000107209.1
Gabpb2
GA repeat binding protein, beta 2
chr12_+_116405397 14.436 ENSMUST00000084828.3
Ncapg2
non-SMC condensin II complex, subunit G2
chr13_+_113035111 14.134 ENSMUST00000180543.1
ENSMUST00000181568.1
ENSMUST00000109244.2
ENSMUST00000181117.1
ENSMUST00000181741.1
Cdc20b




cell division cycle 20B




chr3_+_98013503 14.028 ENSMUST00000079812.6
Notch2
notch 2
chr16_-_15637277 13.870 ENSMUST00000023353.3
Mcm4
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr12_+_71016658 13.701 ENSMUST00000125125.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr1_+_175880775 13.520 ENSMUST00000039725.6
Exo1
exonuclease 1
chr6_+_51470633 13.290 ENSMUST00000114445.1
ENSMUST00000114446.1
ENSMUST00000141711.1
Cbx3


chromobox 3


chrX_+_42150672 13.177 ENSMUST00000069619.7
Stag2
stromal antigen 2
chr3_+_41563356 12.926 ENSMUST00000163764.1
Phf17
PHD finger protein 17
chr14_+_51984826 12.895 ENSMUST00000093813.5
Arhgef40
Rho guanine nucleotide exchange factor (GEF) 40
chr9_-_20952838 12.771 ENSMUST00000004202.9
Dnmt1
DNA methyltransferase (cytosine-5) 1
chr4_+_132768325 12.336 ENSMUST00000102561.4
Rpa2
replication protein A2
chr2_-_154569845 12.234 ENSMUST00000103145.4
E2f1
E2F transcription factor 1
chr14_+_51984857 12.103 ENSMUST00000100639.4
ENSMUST00000182909.1
ENSMUST00000182760.1
ENSMUST00000182061.1
ENSMUST00000182193.1
Arhgef40




Rho guanine nucleotide exchange factor (GEF) 40




chr15_+_102296256 12.058 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr3_+_96104498 12.020 ENSMUST00000132980.1
ENSMUST00000138206.1
ENSMUST00000090785.2
ENSMUST00000035519.5
Otud7b



OTU domain containing 7B



chr10_-_21160925 11.985 ENSMUST00000020158.6
Myb
myeloblastosis oncogene
chr9_+_109875541 11.954 ENSMUST00000094324.3
Cdc25a
cell division cycle 25A
chr2_+_150909565 11.859 ENSMUST00000028948.4
Gins1
GINS complex subunit 1 (Psf1 homolog)
chr16_-_18811615 11.653 ENSMUST00000096990.3
Cdc45
cell division cycle 45
chr17_+_29490812 11.093 ENSMUST00000024811.6
Pim1
proviral integration site 1
chr10_-_7956223 11.023 ENSMUST00000146444.1
Tab2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr9_+_65890237 10.783 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr7_-_38107490 10.667 ENSMUST00000108023.3
Ccne1
cyclin E1
chr1_+_157412352 10.638 ENSMUST00000061537.5
2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr9_+_103305156 10.475 ENSMUST00000035164.3
Topbp1
topoisomerase (DNA) II binding protein 1
chr8_+_95633500 10.468 ENSMUST00000034094.9
Gins3
GINS complex subunit 3 (Psf3 homolog)
chr19_+_8723478 10.457 ENSMUST00000180819.1
ENSMUST00000181422.1
Snhg1

small nucleolar RNA host gene (non-protein coding) 1

chr3_-_95217741 10.421 ENSMUST00000107204.1
Gabpb2
GA repeat binding protein, beta 2
chr7_+_13278778 10.399 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
Lig1


ligase I, DNA, ATP-dependent


chr9_-_97018823 10.248 ENSMUST00000055433.4
Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
chr12_+_112644828 10.202 ENSMUST00000021728.4
ENSMUST00000109755.3
Siva1

SIVA1, apoptosis-inducing factor

chr17_+_56303321 9.837 ENSMUST00000001258.8
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr2_-_154569720 9.733 ENSMUST00000000894.5
E2f1
E2F transcription factor 1
chr7_-_44548733 9.696 ENSMUST00000145956.1
ENSMUST00000049343.8
Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr2_-_5012716 9.656 ENSMUST00000027980.7
Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
chr17_+_23726336 9.630 ENSMUST00000024701.7
Pkmyt1
protein kinase, membrane associated tyrosine/threonine 1
chr1_+_184034381 9.580 ENSMUST00000048655.7
Dusp10
dual specificity phosphatase 10
chr9_-_36726374 9.221 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
Chek1


checkpoint kinase 1


chrX_+_50841434 9.041 ENSMUST00000114887.2
2610018G03Rik
RIKEN cDNA 2610018G03 gene
chr5_-_138171813 8.896 ENSMUST00000155902.1
ENSMUST00000148879.1
Mcm7

minichromosome maintenance deficient 7 (S. cerevisiae)

chr5_+_110839973 8.876 ENSMUST00000066160.1
Chek2
checkpoint kinase 2
chr16_-_18248697 8.871 ENSMUST00000115645.3
Ranbp1
RAN binding protein 1
chr5_-_138172383 8.642 ENSMUST00000000505.9
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr7_+_79392305 8.612 ENSMUST00000117227.1
ENSMUST00000118959.1
ENSMUST00000036865.6
Fanci


Fanconi anemia, complementation group I


chr7_-_6730412 8.505 ENSMUST00000051209.4
Peg3
paternally expressed 3
chr2_+_53192067 8.499 ENSMUST00000028336.6
Arl6ip6
ADP-ribosylation factor-like 6 interacting protein 6
chr5_+_52741569 8.493 ENSMUST00000031081.4
ENSMUST00000031082.6
Pi4k2b

phosphatidylinositol 4-kinase type 2 beta

chrX_-_73458990 8.447 ENSMUST00000033737.8
ENSMUST00000077243.4
Haus7

HAUS augmin-like complex, subunit 7

chr10_+_128232065 8.379 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
Timeless




timeless circadian clock 1




chr2_+_70474923 8.367 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr7_-_100121512 8.337 ENSMUST00000032969.7
Pold3
polymerase (DNA-directed), delta 3, accessory subunit
chr15_-_79605084 8.289 ENSMUST00000023065.6
Dmc1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
chr1_+_86526688 8.226 ENSMUST00000045897.8
Ptma
prothymosin alpha
chr1_-_86359455 8.188 ENSMUST00000027438.6
Ncl
nucleolin
chr6_+_113531675 7.972 ENSMUST00000036340.5
ENSMUST00000101051.2
Fancd2

Fanconi anemia, complementation group D2

chrX_+_112311334 7.929 ENSMUST00000026599.3
ENSMUST00000113415.1
Apool

apolipoprotein O-like

chr14_+_59625281 7.813 ENSMUST00000053949.5
Shisa2
shisa homolog 2 (Xenopus laevis)
chr14_-_67933512 7.799 ENSMUST00000039135.4
Dock5
dedicator of cytokinesis 5
chr1_+_131910458 7.770 ENSMUST00000062264.6
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr10_+_13090788 7.665 ENSMUST00000121646.1
ENSMUST00000121325.1
ENSMUST00000121766.1
Plagl1


pleiomorphic adenoma gene-like 1


chr4_-_132843111 7.649 ENSMUST00000105919.1
ENSMUST00000030702.7
Ppp1r8

protein phosphatase 1, regulatory (inhibitor) subunit 8

chr2_-_132253227 7.611 ENSMUST00000028817.6
Pcna
proliferating cell nuclear antigen
chr7_+_102441685 7.494 ENSMUST00000033283.9
Rrm1
ribonucleotide reductase M1
chrX_-_8074720 7.438 ENSMUST00000115636.3
ENSMUST00000115638.3
Suv39h1

suppressor of variegation 3-9 homolog 1 (Drosophila)

chr10_+_11281583 7.398 ENSMUST00000070300.4
Fbxo30
F-box protein 30
chr5_-_149051604 7.394 ENSMUST00000093196.4
Hmgb1
high mobility group box 1
chr4_+_11191354 7.365 ENSMUST00000170901.1
Ccne2
cyclin E2
chr19_-_5964132 7.144 ENSMUST00000025752.7
ENSMUST00000165143.1
Pola2

polymerase (DNA directed), alpha 2

chr8_+_72135247 7.091 ENSMUST00000003575.9
Tpm4
tropomyosin 4
chr9_-_13827029 7.060 ENSMUST00000148086.1
ENSMUST00000034398.5
Cep57

centrosomal protein 57

chr8_+_87472805 7.021 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
Gm2694


predicted gene 2694


chr11_-_6444352 7.016 ENSMUST00000093346.5
ENSMUST00000109737.2
H2afv

H2A histone family, member V

chr11_+_108920342 6.859 ENSMUST00000052915.7
Axin2
axin2
chr9_-_72491939 6.852 ENSMUST00000185151.1
ENSMUST00000085358.5
ENSMUST00000184125.1
ENSMUST00000183574.1
ENSMUST00000184831.1
Tex9




testis expressed gene 9




chr4_-_143299498 6.793 ENSMUST00000030317.7
Pdpn
podoplanin
chr11_+_98907801 6.755 ENSMUST00000092706.6
Cdc6
cell division cycle 6
chr8_-_105707933 6.749 ENSMUST00000013299.9
Enkd1
enkurin domain containing 1
chr5_-_110286159 6.699 ENSMUST00000031472.5
Pxmp2
peroxisomal membrane protein 2
chr19_-_10203880 6.611 ENSMUST00000142241.1
ENSMUST00000116542.2
ENSMUST00000025651.5
ENSMUST00000156291.1
Fen1



flap structure specific endonuclease 1



chr4_-_143299463 6.566 ENSMUST00000119654.1
Pdpn
podoplanin
chr1_+_93803945 6.559 ENSMUST00000027505.6
Ing5
inhibitor of growth family, member 5
chr8_-_53638945 6.535 ENSMUST00000047768.4
Neil3
nei like 3 (E. coli)
chr17_+_28801090 6.399 ENSMUST00000004985.9
Brpf3
bromodomain and PHD finger containing, 3
chr1_-_9700209 6.289 ENSMUST00000088658.4
Mybl1
myeloblastosis oncogene-like 1
chr15_+_55557399 6.269 ENSMUST00000022998.7
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr17_+_87975044 6.241 ENSMUST00000005503.3
Msh6
mutS homolog 6 (E. coli)
chr6_+_51470510 6.240 ENSMUST00000031862.7
Cbx3
chromobox 3
chr6_-_148946146 6.180 ENSMUST00000132696.1
Fam60a
family with sequence similarity 60, member A
chr6_-_4747157 6.156 ENSMUST00000090686.4
ENSMUST00000115579.1
ENSMUST00000115577.2
ENSMUST00000101677.3
ENSMUST00000004750.8
Sgce




sarcoglycan, epsilon




chr14_-_104467984 5.963 ENSMUST00000053016.8
Pou4f1
POU domain, class 4, transcription factor 1
chr3_-_145649970 5.893 ENSMUST00000029846.3
Cyr61
cysteine rich protein 61
chr13_-_47106176 5.742 ENSMUST00000021807.6
ENSMUST00000135278.1
Dek

DEK oncogene (DNA binding)

chr3_+_127553462 5.690 ENSMUST00000043108.4
4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr4_+_134864536 5.633 ENSMUST00000030627.7
Rhd
Rh blood group, D antigen
chr11_+_88068242 5.633 ENSMUST00000018521.4
Vezf1
vascular endothelial zinc finger 1
chr11_+_88718442 5.536 ENSMUST00000138007.1
C030037D09Rik
RIKEN cDNA C030037D09 gene
chr8_+_87472838 5.496 ENSMUST00000180806.2
Gm2694
predicted gene 2694
chr4_-_107683576 5.479 ENSMUST00000131776.1
Dmrtb1
DMRT-like family B with proline-rich C-terminal, 1
chr16_-_5255923 5.427 ENSMUST00000139584.1
ENSMUST00000064635.5
Fam86

family with sequence similarity 86

chr10_-_128891674 5.309 ENSMUST00000026408.6
Gdf11
growth differentiation factor 11
chr2_+_103970221 5.060 ENSMUST00000111140.2
ENSMUST00000111139.2
Lmo2

LIM domain only 2

chr13_-_102958084 5.060 ENSMUST00000099202.3
ENSMUST00000172264.1
Mast4

microtubule associated serine/threonine kinase family member 4

chr1_+_15805639 4.971 ENSMUST00000027057.6
Terf1
telomeric repeat binding factor 1
chr7_-_130266237 4.927 ENSMUST00000117872.1
ENSMUST00000120187.1
Fgfr2

fibroblast growth factor receptor 2

chr2_+_129800451 4.881 ENSMUST00000165413.2
ENSMUST00000166282.2
Stk35

serine/threonine kinase 35

chr15_+_55557575 4.864 ENSMUST00000170046.1
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr2_+_103970115 4.852 ENSMUST00000111143.1
ENSMUST00000138815.1
Lmo2

LIM domain only 2

chr8_+_87473116 4.821 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
Gm2694


predicted gene 2694


chr17_-_71475285 4.788 ENSMUST00000127430.1
Smchd1
SMC hinge domain containing 1
chr13_-_106936907 4.767 ENSMUST00000080856.7
Ipo11
importin 11
chr7_-_130266191 4.756 ENSMUST00000122054.1
Fgfr2
fibroblast growth factor receptor 2
chr10_+_58323466 4.710 ENSMUST00000020078.7
Lims1
LIM and senescent cell antigen-like domains 1
chr4_-_126968124 4.687 ENSMUST00000106108.2
Zmym4
zinc finger, MYM-type 4
chr2_+_85037212 4.683 ENSMUST00000077798.6
Ssrp1
structure specific recognition protein 1
chr3_-_127553233 4.675 ENSMUST00000029588.5
Larp7
La ribonucleoprotein domain family, member 7
chrX_-_139871637 4.668 ENSMUST00000033811.7
ENSMUST00000087401.5
Morc4

microrchidia 4

chr7_-_133122615 4.640 ENSMUST00000167218.1
Ctbp2
C-terminal binding protein 2
chr3_+_104638658 4.616 ENSMUST00000046212.1
Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr6_-_4747019 4.485 ENSMUST00000126151.1
ENSMUST00000133306.1
ENSMUST00000123907.1
Sgce


sarcoglycan, epsilon


chr7_+_131542867 4.457 ENSMUST00000046093.5
Hmx3
H6 homeobox 3
chr11_-_87404380 4.441 ENSMUST00000067692.6
Rad51c
RAD51 homolog C
chr19_+_53600377 4.407 ENSMUST00000025930.9
Smc3
structural maintenance of chromosomes 3
chr2_-_170142673 4.379 ENSMUST00000109155.1
Zfp217
zinc finger protein 217
chr6_-_47594967 4.355 ENSMUST00000081721.6
ENSMUST00000114618.1
ENSMUST00000114616.1
Ezh2


enhancer of zeste homolog 2 (Drosophila)


chr7_+_66109474 4.334 ENSMUST00000036372.6
Chsy1
chondroitin sulfate synthase 1
chr1_+_74661714 4.296 ENSMUST00000042125.8
ENSMUST00000141119.1
Ttll4

tubulin tyrosine ligase-like family, member 4

chr13_-_63431683 4.258 ENSMUST00000160931.1
ENSMUST00000099444.3
ENSMUST00000161977.1
ENSMUST00000163091.1
Fancc



Fanconi anemia, complementation group C



chr1_+_74661794 4.257 ENSMUST00000129890.1
Ttll4
tubulin tyrosine ligase-like family, member 4
chr10_+_52233612 4.246 ENSMUST00000069004.5
ENSMUST00000105476.2
Dcbld1

discoidin, CUB and LCCL domain containing 1

chr9_-_108452377 4.218 ENSMUST00000035232.7
Klhdc8b
kelch domain containing 8B
chr11_+_79993062 4.187 ENSMUST00000017692.8
ENSMUST00000163272.1
Suz12

suppressor of zeste 12 homolog (Drosophila)

chr12_+_111166413 4.147 ENSMUST00000021706.4
Traf3
TNF receptor-associated factor 3
chr5_+_88764983 4.125 ENSMUST00000031311.9
Dck
deoxycytidine kinase
chr1_-_38129618 4.014 ENSMUST00000027251.6
Rev1
REV1 homolog (S. cerevisiae)
chr15_-_8444449 4.013 ENSMUST00000052965.6
Nipbl
Nipped-B homolog (Drosophila)
chr2_-_34913976 3.960 ENSMUST00000028232.3
Phf19
PHD finger protein 19
chr14_-_34503323 3.947 ENSMUST00000171343.1
Bmpr1a
bone morphogenetic protein receptor, type 1A
chr15_+_8109313 3.848 ENSMUST00000163765.1
Nup155
nucleoporin 155
chr4_-_151057933 3.819 ENSMUST00000030797.3
Vamp3
vesicle-associated membrane protein 3
chr5_-_77115145 3.769 ENSMUST00000081964.5
Hopx
HOP homeobox
chr17_-_23740301 3.703 ENSMUST00000024702.3
Paqr4
progestin and adipoQ receptor family member IV
chr4_-_133967953 3.693 ENSMUST00000102553.4
Hmgn2
high mobility group nucleosomal binding domain 2
chr9_-_111271568 3.654 ENSMUST00000035079.3
Mlh1
mutL homolog 1 (E. coli)
chr19_-_29648355 3.554 ENSMUST00000159692.1
Ermp1
endoplasmic reticulum metallopeptidase 1

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
23.2 69.5 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
10.6 74.0 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
8.4 67.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
8.1 105.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
7.3 22.0 GO:0006285 base-excision repair, AP site formation(GO:0006285)
7.2 28.7 GO:0046655 glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655)
7.0 27.8 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
6.8 27.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
6.5 51.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
5.9 59.2 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
5.6 135.1 GO:0006270 DNA replication initiation(GO:0006270)
5.5 76.5 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
5.4 43.4 GO:0033504 floor plate development(GO:0033504)
5.3 31.8 GO:0006287 base-excision repair, gap-filling(GO:0006287)
5.2 20.8 GO:0098763 mitotic cell cycle phase(GO:0098763)
5.1 20.2 GO:0000076 DNA replication checkpoint(GO:0000076)
5.0 20.1 GO:0071139 resolution of recombination intermediates(GO:0071139)
5.0 25.0 GO:0034421 post-translational protein acetylation(GO:0034421)
4.8 28.7 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
4.7 14.0 GO:0035622 intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705)
4.4 17.8 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
4.2 29.6 GO:0019985 translesion synthesis(GO:0019985)
3.7 22.3 GO:1902969 mitotic DNA replication(GO:1902969)
3.6 32.1 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
3.4 27.3 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
3.2 9.7 GO:0035604 orbitofrontal cortex development(GO:0021769) fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development(GO:0035607) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
3.1 45.8 GO:0034501 protein localization to kinetochore(GO:0034501)
3.0 18.1 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
2.9 23.1 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
2.8 27.8 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
2.5 12.7 GO:0042148 strand invasion(GO:0042148)
2.5 7.4 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
2.4 12.0 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
2.4 9.6 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268)
2.3 13.7 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
2.1 8.3 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
2.0 8.2 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
2.0 5.9 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
1.9 7.8 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
1.7 6.9 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
1.7 5.0 GO:0031627 telomeric loop formation(GO:0031627)
1.6 4.8 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
1.6 8.0 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
1.6 11.1 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
1.6 22.1 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
1.6 76.5 GO:0008156 negative regulation of DNA replication(GO:0008156)
1.5 3.0 GO:0061074 regulation of neural retina development(GO:0061074)
1.5 12.1 GO:1901970 meiotic chromosome separation(GO:0051307) positive regulation of mitotic sister chromatid separation(GO:1901970)
1.5 4.5 GO:0002184 cytoplasmic translational termination(GO:0002184)
1.5 7.4 GO:0003223 ventricular compact myocardium morphogenesis(GO:0003223)
1.4 5.7 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
1.4 5.5 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
1.4 4.1 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
1.3 13.4 GO:0015884 positive regulation of platelet activation(GO:0010572) folic acid transport(GO:0015884)
1.3 6.6 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
1.3 4.0 GO:0061085 positive regulation of histone methylation(GO:0031062) regulation of histone H3-K27 methylation(GO:0061085) positive regulation of histone H3-K27 methylation(GO:0061087)
1.3 3.9 GO:0048352 neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378)
1.3 3.8 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
1.2 7.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.2 12.2 GO:0008063 Toll signaling pathway(GO:0008063)
1.2 12.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
1.2 4.7 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
1.1 10.2 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030)
1.1 5.6 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.1 3.4 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
1.1 14.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.1 48.7 GO:0043550 regulation of lipid kinase activity(GO:0043550)
1.1 3.3 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
1.1 28.7 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
1.0 4.1 GO:0046125 pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
1.0 4.0 GO:0061010 gall bladder development(GO:0061010)
1.0 8.6 GO:0018095 protein polyglutamylation(GO:0018095)
0.9 3.8 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.9 6.3 GO:0001887 selenium compound metabolic process(GO:0001887)
0.9 10.5 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.9 4.4 GO:0035984 response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
0.8 4.2 GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.8 7.4 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.8 8.8 GO:0006298 mismatch repair(GO:0006298)
0.8 9.9 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.7 3.3 GO:0036337 Fas signaling pathway(GO:0036337)
0.7 1.3 GO:0033484 nitric oxide homeostasis(GO:0033484)
0.6 2.5 GO:0072697 protein localization to cell cortex(GO:0072697)
0.6 1.9 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.6 7.8 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.6 4.7 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.6 2.3 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.6 1.7 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.6 7.3 GO:0030238 male sex determination(GO:0030238)
0.5 1.6 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990)
0.5 8.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095) mitotic G2/M transition checkpoint(GO:0044818)
0.5 1.6 GO:2000015 regulation of determination of dorsal identity(GO:2000015)
0.5 34.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.5 4.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.5 2.5 GO:0060056 mammary gland involution(GO:0060056)
0.5 7.9 GO:0042407 cristae formation(GO:0042407)
0.5 1.5 GO:0006597 spermine biosynthetic process(GO:0006597)
0.5 3.4 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.5 1.9 GO:1904008 response to monosodium glutamate(GO:1904008) cellular response to monosodium glutamate(GO:1904009)
0.5 1.8 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.5 8.2 GO:0043486 histone exchange(GO:0043486)
0.4 16.1 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.4 4.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.4 2.1 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.4 1.2 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.4 2.0 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.4 22.2 GO:0000725 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.4 8.5 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.4 3.4 GO:0060968 regulation of gene silencing(GO:0060968)
0.4 0.8 GO:0007341 penetration of zona pellucida(GO:0007341)
0.4 8.4 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.4 2.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.4 7.1 GO:0034453 microtubule anchoring(GO:0034453)
0.3 2.4 GO:1904251 regulation of bile acid metabolic process(GO:1904251)
0.3 7.1 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.3 7.8 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.3 3.0 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.3 4.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3 2.5 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.3 1.4 GO:0006983 ER overload response(GO:0006983)
0.3 0.5 GO:0023035 CD40 signaling pathway(GO:0023035)
0.3 0.8 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.3 5.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.3 3.1 GO:0009143 nucleoside triphosphate catabolic process(GO:0009143)
0.3 2.8 GO:0080009 mRNA methylation(GO:0080009)
0.2 1.9 GO:0007020 microtubule nucleation(GO:0007020)
0.2 1.4 GO:0009249 protein lipoylation(GO:0009249)
0.2 5.3 GO:0021511 spinal cord patterning(GO:0021511)
0.2 2.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 0.7 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.2 2.6 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.2 2.6 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.2 0.6 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.2 4.6 GO:0032094 response to food(GO:0032094)
0.2 3.5 GO:2000772 regulation of cellular senescence(GO:2000772)
0.2 2.7 GO:0002021 response to dietary excess(GO:0002021)
0.2 0.5 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.2 25.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 9.6 GO:0043966 histone H3 acetylation(GO:0043966)
0.2 4.0 GO:0006284 base-excision repair(GO:0006284)
0.2 2.1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.1 4.7 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.1 3.8 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.1 1.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 1.9 GO:0010388 cullin deneddylation(GO:0010388)
0.1 0.5 GO:0010826 negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.1 2.9 GO:0007340 acrosome reaction(GO:0007340)
0.1 5.4 GO:0007569 cell aging(GO:0007569)
0.1 8.0 GO:0007548 sex differentiation(GO:0007548)
0.1 2.6 GO:0007099 centriole replication(GO:0007099)
0.1 3.3 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.8 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.1 8.4 GO:0051225 spindle assembly(GO:0051225)
0.1 1.4 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.1 1.6 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 0.6 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.1 11.6 GO:0048511 rhythmic process(GO:0048511)
0.1 2.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 3.0 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 5.6 GO:0001885 endothelial cell development(GO:0001885)
0.1 0.6 GO:0016139 glycoside catabolic process(GO:0016139)
0.1 3.0 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 3.1 GO:0034605 cellular response to heat(GO:0034605)
0.1 2.0 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.1 1.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 0.6 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 1.1 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 0.4 GO:0007197 gastric acid secretion(GO:0001696) adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.8 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.1 8.0 GO:0006260 DNA replication(GO:0006260)
0.1 6.7 GO:0030010 establishment of cell polarity(GO:0030010)
0.1 2.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 1.0 GO:0006221 pyrimidine nucleotide biosynthetic process(GO:0006221)
0.0 2.4 GO:0016925 protein sumoylation(GO:0016925)
0.0 1.1 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.4 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 2.1 GO:0048477 oogenesis(GO:0048477)
0.0 2.0 GO:0051028 mRNA transport(GO:0051028)
0.0 1.9 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.7 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.0 3.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.4 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 1.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.8 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.4 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 6.0 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.0 0.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.5 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.0 2.6 GO:0034976 response to endoplasmic reticulum stress(GO:0034976)
0.0 1.9 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.7 GO:0006970 response to osmotic stress(GO:0006970)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
13.3 66.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
10.7 160.0 GO:0042555 MCM complex(GO:0042555)
10.0 29.9 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
7.3 36.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
4.8 9.7 GO:0031298 replication fork protection complex(GO:0031298)
4.4 22.0 GO:0035189 Rb-E2F complex(GO:0035189)
3.9 11.7 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
3.6 21.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
3.5 10.6 GO:0000811 GINS complex(GO:0000811)
3.3 32.6 GO:0000800 lateral element(GO:0000800)
3.2 9.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
3.1 25.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
2.7 10.6 GO:0016012 sarcoglycan complex(GO:0016012)
2.5 7.6 GO:0070557 PCNA-p21 complex(GO:0070557)
2.0 8.2 GO:0001651 dense fibrillar component(GO:0001651)
1.9 99.2 GO:0005657 replication fork(GO:0005657)
1.9 5.7 GO:0035061 interchromatin granule(GO:0035061)
1.9 18.8 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
1.8 10.9 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
1.8 14.1 GO:0001673 male germ cell nucleus(GO:0001673)
1.5 7.4 GO:0033553 rDNA heterochromatin(GO:0033553)
1.5 4.5 GO:0018444 translation release factor complex(GO:0018444)
1.3 2.6 GO:0000801 central element(GO:0000801)
1.1 3.3 GO:0043527 tRNA methyltransferase complex(GO:0043527)
1.1 8.4 GO:0070652 HAUS complex(GO:0070652)
1.0 4.8 GO:0001740 Barr body(GO:0001740)
0.9 12.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.9 7.9 GO:0061617 MICOS complex(GO:0061617)
0.8 5.9 GO:0032300 mismatch repair complex(GO:0032300)
0.8 5.0 GO:0070187 telosome(GO:0070187)
0.8 12.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.8 8.9 GO:1904115 axon cytoplasm(GO:1904115)
0.8 6.2 GO:0016580 Sin3 complex(GO:0016580)
0.8 3.8 GO:0044611 nuclear pore inner ring(GO:0044611)
0.7 15.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.6 1.8 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.6 32.8 GO:0005871 kinesin complex(GO:0005871)
0.6 3.4 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.6 33.2 GO:0005876 spindle microtubule(GO:0005876)
0.6 2.8 GO:0005683 U7 snRNP(GO:0005683)
0.5 1.4 GO:0031251 PAN complex(GO:0031251)
0.4 2.6 GO:0044530 supraspliceosomal complex(GO:0044530)
0.4 2.9 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.4 175.5 GO:0005667 transcription factor complex(GO:0005667)
0.4 27.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.4 39.6 GO:0005814 centriole(GO:0005814)
0.4 2.8 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.4 1.5 GO:0001652 granular component(GO:0001652)
0.4 8.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.3 1.0 GO:0090543 Flemming body(GO:0090543)
0.3 4.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.3 1.7 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.3 1.0 GO:0016342 catenin complex(GO:0016342)
0.3 1.8 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 1.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.3 7.1 GO:0002102 podosome(GO:0002102)
0.3 4.6 GO:0097470 ribbon synapse(GO:0097470)
0.3 4.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.3 32.1 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.3 3.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 12.1 GO:0072686 mitotic spindle(GO:0072686)
0.2 12.2 GO:0000922 spindle pole(GO:0000922)
0.2 12.5 GO:0000793 condensed chromosome(GO:0000793)
0.2 2.0 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 2.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 1.2 GO:0034709 methylosome(GO:0034709)
0.2 5.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 2.6 GO:0005686 U2 snRNP(GO:0005686)
0.2 14.1 GO:0016605 PML body(GO:0016605)
0.2 4.7 GO:0016363 nuclear matrix(GO:0016363)
0.2 6.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 3.8 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 9.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 2.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.2 GO:0001741 XY body(GO:0001741)
0.1 0.8 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 1.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.7 GO:0070695 FHF complex(GO:0070695)
0.1 7.6 GO:0000776 kinetochore(GO:0000776)
0.1 1.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 6.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 9.6 GO:0005681 spliceosomal complex(GO:0005681)
0.1 0.8 GO:0031595 nuclear proteasome complex(GO:0031595)
0.1 21.0 GO:0000139 Golgi membrane(GO:0000139)
0.1 169.7 GO:0005654 nucleoplasm(GO:0005654)
0.1 2.6 GO:0001772 immunological synapse(GO:0001772)
0.1 13.4 GO:0030027 lamellipodium(GO:0030027)
0.1 0.7 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 2.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 37.1 GO:0005730 nucleolus(GO:0005730)
0.1 3.9 GO:0005901 caveola(GO:0005901)
0.1 1.4 GO:0035770 ribonucleoprotein granule(GO:0035770)
0.1 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.5 GO:0036038 MKS complex(GO:0036038)
0.1 180.5 GO:0005634 nucleus(GO:0005634)
0.0 0.4 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 4.7 GO:0005925 focal adhesion(GO:0005925)
0.0 0.1 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
21.2 63.7 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
13.3 66.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
11.2 67.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
9.6 28.7 GO:0051870 methotrexate binding(GO:0051870)
9.4 75.2 GO:0003688 DNA replication origin binding(GO:0003688)
6.9 27.8 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
5.8 40.9 GO:0000150 recombinase activity(GO:0000150)
5.0 20.1 GO:0048256 flap endonuclease activity(GO:0048256)
4.2 16.6 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
3.8 26.8 GO:0003896 DNA primase activity(GO:0003896)
3.8 67.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
3.4 6.8 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
3.1 9.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
3.0 9.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
2.8 11.2 GO:0071987 WD40-repeat domain binding(GO:0071987)
2.5 7.4 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
2.4 12.0 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
2.3 61.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
2.3 25.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.9 22.9 GO:1990226 histone methyltransferase binding(GO:1990226)
1.8 7.3 GO:0045131 pre-mRNA branch point binding(GO:0045131)
1.8 28.5 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
1.7 10.4 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
1.7 20.6 GO:0031996 thioesterase binding(GO:0031996)
1.7 8.5 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
1.6 94.7 GO:0003678 DNA helicase activity(GO:0003678)
1.6 31.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
1.5 13.4 GO:0008517 folic acid transporter activity(GO:0008517)
1.4 4.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
1.4 16.6 GO:0070182 DNA polymerase binding(GO:0070182)
1.4 8.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
1.3 6.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.2 1.2 GO:0032138 single base insertion or deletion binding(GO:0032138)
1.2 7.4 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
1.1 9.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
1.0 4.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.9 2.8 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.9 5.5 GO:0051525 NFAT protein binding(GO:0051525)
0.9 11.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.8 5.0 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.8 63.0 GO:0070491 repressing transcription factor binding(GO:0070491)
0.8 6.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.8 139.6 GO:0001047 core promoter binding(GO:0001047)
0.7 0.7 GO:0016751 S-succinyltransferase activity(GO:0016751)
0.7 3.9 GO:0098821 BMP receptor activity(GO:0098821)
0.6 4.0 GO:0070087 chromo shadow domain binding(GO:0070087)
0.5 2.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.5 10.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.5 11.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.5 2.0 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.5 4.5 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.5 7.9 GO:0070411 I-SMAD binding(GO:0070411)
0.5 32.8 GO:0003777 microtubule motor activity(GO:0003777)
0.5 2.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.5 3.3 GO:0032184 SUMO polymer binding(GO:0032184)
0.4 7.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.4 3.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.4 14.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.4 2.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.4 1.2 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.4 17.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.4 2.3 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.4 21.1 GO:0035064 methylated histone binding(GO:0035064)
0.4 2.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.4 1.8 GO:0005047 signal recognition particle binding(GO:0005047)
0.3 5.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.3 1.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.3 3.0 GO:0000400 four-way junction DNA binding(GO:0000400)
0.3 4.2 GO:0031386 protein tag(GO:0031386)
0.3 9.9 GO:0070888 E-box binding(GO:0070888)
0.3 4.6 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.3 7.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.3 4.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.3 11.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.3 2.8 GO:0004526 ribonuclease P activity(GO:0004526)
0.3 3.3 GO:0048038 quinone binding(GO:0048038)
0.3 31.3 GO:0042393 histone binding(GO:0042393)
0.2 11.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 4.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 14.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 25.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 5.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 20.5 GO:0004386 helicase activity(GO:0004386)
0.2 3.1 GO:0016462 pyrophosphatase activity(GO:0016462)
0.2 4.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 50.8 GO:0005096 GTPase activator activity(GO:0005096)
0.2 35.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 56.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 1.6 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 3.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 10.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 0.8 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 4.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 5.3 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 2.8 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.8 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 3.0 GO:0005112 Notch binding(GO:0005112)
0.1 4.4 GO:0045502 dynein binding(GO:0045502)
0.1 55.8 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.1 2.0 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.1 0.4 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 5.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.9 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.8 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 2.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 19.2 GO:0003682 chromatin binding(GO:0003682)
0.1 0.8 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 3.4 GO:0004772 sterol O-acyltransferase activity(GO:0004772)
0.1 19.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 1.1 GO:0017161 protein tyrosine/threonine phosphatase activity(GO:0008330) JUN kinase phosphatase activity(GO:0008579) phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) transmembrane receptor protein phosphatase activity(GO:0019198) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.1 1.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 2.0 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 1.7 GO:0030332 cyclin binding(GO:0030332)
0.1 4.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 3.6 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 8.9 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.1 0.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 7.8 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 1.4 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.5 GO:0002039 p53 binding(GO:0002039)
0.0 4.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.5 GO:0031005 filamin binding(GO:0031005)
0.0 0.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 6.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.4 GO:0034946 2-oxoglutaryl-CoA thioesterase activity(GO:0034843) 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity(GO:0034869) 3-isopropylbut-3-enoyl-CoA thioesterase activity(GO:0034946) glutaryl-CoA hydrolase activity(GO:0044466)
0.0 1.5 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 2.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 3.6 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)