Motif ID: E2f2_E2f5
Z-value: 4.060
Transcription factors associated with E2f2_E2f5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| E2f2 | ENSMUSG00000018983.9 | E2f2 |
| E2f5 | ENSMUSG00000027552.8 | E2f5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f2 | mm10_v2_chr4_+_136172367_136172395 | 0.93 | 3.0e-27 | Click! |
| E2f5 | mm10_v2_chr3_+_14578609_14578687 | 0.80 | 4.7e-14 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 192 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 135.1 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 8.1 | 105.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 5.5 | 76.5 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 1.6 | 76.5 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 10.6 | 74.0 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 23.2 | 69.5 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 8.4 | 67.4 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 5.9 | 59.2 | GO:0009186 | deoxyribonucleoside diphosphate metabolic process(GO:0009186) |
| 6.5 | 51.8 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 1.1 | 48.7 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
| 3.1 | 45.8 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 5.4 | 43.4 | GO:0033504 | floor plate development(GO:0033504) |
| 0.5 | 34.5 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
| 3.6 | 32.1 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 5.3 | 31.8 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
| 4.2 | 29.6 | GO:0019985 | translesion synthesis(GO:0019985) |
| 7.2 | 28.7 | GO:0046655 | glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655) |
| 4.8 | 28.7 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 1.1 | 28.7 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 7.0 | 27.8 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 101 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 180.5 | GO:0005634 | nucleus(GO:0005634) |
| 0.4 | 175.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 169.7 | GO:0005654 | nucleoplasm(GO:0005654) |
| 10.7 | 160.0 | GO:0042555 | MCM complex(GO:0042555) |
| 1.9 | 99.2 | GO:0005657 | replication fork(GO:0005657) |
| 13.3 | 66.7 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.4 | 39.6 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 37.1 | GO:0005730 | nucleolus(GO:0005730) |
| 7.3 | 36.3 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.6 | 33.2 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.6 | 32.8 | GO:0005871 | kinesin complex(GO:0005871) |
| 3.3 | 32.6 | GO:0000800 | lateral element(GO:0000800) |
| 0.3 | 32.1 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 10.0 | 29.9 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.4 | 27.3 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 3.1 | 25.0 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 4.4 | 22.0 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 3.6 | 21.5 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 21.0 | GO:0000139 | Golgi membrane(GO:0000139) |
| 1.9 | 18.8 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 131 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 139.6 | GO:0001047 | core promoter binding(GO:0001047) |
| 1.6 | 94.7 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 9.4 | 75.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 3.8 | 67.7 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 11.2 | 67.4 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 13.3 | 66.7 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 21.2 | 63.7 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.8 | 63.0 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 2.3 | 61.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.2 | 56.7 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 55.8 | GO:0044212 | transcription regulatory region DNA binding(GO:0044212) |
| 0.2 | 50.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 5.8 | 40.9 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.2 | 35.2 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.5 | 32.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.3 | 31.3 | GO:0042393 | histone binding(GO:0042393) |
| 1.6 | 31.2 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 9.6 | 28.7 | GO:0051870 | methotrexate binding(GO:0051870) |
| 1.8 | 28.5 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 6.9 | 27.8 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
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