Motif ID: E2f4

Z-value: 2.600


Transcription factors associated with E2f4:

Gene SymbolEntrez IDGene Name
E2f4 ENSMUSG00000014859.8 E2f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.783.2e-13Click!


Activity profile for motif E2f4.

activity profile for motif E2f4


Sorted Z-values histogram for motif E2f4

Sorted Z-values for motif E2f4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 174 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_132345686 28.336 ENSMUST00000030726.6
Rcc1
regulator of chromosome condensation 1
chr4_-_132345715 27.360 ENSMUST00000084250.4
Rcc1
regulator of chromosome condensation 1
chr4_+_134510999 27.001 ENSMUST00000105866.2
Aunip
aurora kinase A and ninein interacting protein
chr19_+_6084983 24.443 ENSMUST00000025704.2
Cdca5
cell division cycle associated 5
chr14_-_47418407 20.654 ENSMUST00000043296.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr2_-_172940299 20.293 ENSMUST00000009143.7
Bmp7
bone morphogenetic protein 7
chr12_+_117843873 20.198 ENSMUST00000176735.1
ENSMUST00000177339.1
Cdca7l

cell division cycle associated 7 like

chr1_-_169531343 19.788 ENSMUST00000028000.7
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr9_+_72438534 19.417 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr9_+_72438519 18.889 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr18_-_34751502 18.290 ENSMUST00000060710.7
Cdc25c
cell division cycle 25C
chr6_+_124830217 17.825 ENSMUST00000131847.1
ENSMUST00000151674.1
Cdca3

cell division cycle associated 3

chr1_-_169531447 17.730 ENSMUST00000111368.1
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr4_-_116123618 17.473 ENSMUST00000102704.3
ENSMUST00000102705.3
Rad54l

RAD54 like (S. cerevisiae)

chr17_-_24251382 17.412 ENSMUST00000115390.3
Ccnf
cyclin F
chr2_+_163054682 17.171 ENSMUST00000018005.3
Mybl2
myeloblastosis oncogene-like 2
chr1_+_157412352 16.931 ENSMUST00000061537.5
2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr18_+_34751803 16.792 ENSMUST00000181453.1
ENSMUST00000181641.1
2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr7_-_38107490 15.819 ENSMUST00000108023.3
Ccne1
cyclin E1
chr11_-_101551837 15.007 ENSMUST00000017290.4
Brca1
breast cancer 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 72.9 GO:0007052 mitotic spindle organization(GO:0007052)
1.2 37.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 34.0 GO:0007067 mitotic nuclear division(GO:0007067)
2.3 32.5 GO:0070986 left/right axis specification(GO:0070986)
1.3 32.0 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.9 30.5 GO:0006270 DNA replication initiation(GO:0006270)
7.4 29.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.3 28.5 GO:0008340 determination of adult lifespan(GO:0008340)
0.5 27.0 GO:0007051 spindle organization(GO:0007051)
3.7 26.0 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
8.1 24.4 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
6.8 20.3 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.8 18.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
6.1 18.3 GO:0000087 mitotic M phase(GO:0000087)
2.5 17.4 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.6 16.1 GO:0006910 phagocytosis, recognition(GO:0006910)
5.0 15.0 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.3 14.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.6 14.5 GO:0051310 metaphase plate congression(GO:0051310)
2.3 13.9 GO:0007144 female meiosis I(GO:0007144)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 52.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.6 41.1 GO:0005882 intermediate filament(GO:0005882)
0.4 37.7 GO:0000922 spindle pole(GO:0000922)
6.3 37.5 GO:0031262 Ndc80 complex(GO:0031262)
2.6 29.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 27.3 GO:0000775 chromosome, centromeric region(GO:0000775)
2.7 24.4 GO:0008278 cohesin complex(GO:0008278)
0.2 21.2 GO:0043198 dendritic shaft(GO:0043198)
0.1 20.8 GO:0031012 extracellular matrix(GO:0031012)
1.3 20.7 GO:0031616 spindle pole centrosome(GO:0031616)
3.4 20.5 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 20.2 GO:0005730 nucleolus(GO:0005730)
0.0 18.9 GO:0005667 transcription factor complex(GO:0005667)
0.3 18.4 GO:0005643 nuclear pore(GO:0005643)
0.3 17.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
3.4 17.2 GO:0031523 Myb complex(GO:0031523)
0.0 17.2 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.3 15.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.5 15.0 GO:0070531 BRCA1-A complex(GO:0070531)
1.3 14.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
8.0 55.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 49.8 GO:0042802 identical protein binding(GO:0042802)
4.9 29.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 27.4 GO:0003682 chromatin binding(GO:0003682)
0.1 24.5 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
2.0 20.3 GO:0070700 BMP receptor binding(GO:0070700)
0.6 18.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.5 18.3 GO:0050699 WW domain binding(GO:0050699)
1.7 17.5 GO:0036310 annealing helicase activity(GO:0036310)
2.5 17.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 15.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.4 15.4 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.3 14.5 GO:0045502 dynein binding(GO:0045502)
1.0 14.3 GO:0070182 DNA polymerase binding(GO:0070182)
1.7 13.4 GO:0042609 CD4 receptor binding(GO:0042609)
1.2 13.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 12.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
2.4 11.9 GO:0000405 bubble DNA binding(GO:0000405)
0.2 11.9 GO:0003684 damaged DNA binding(GO:0003684)
3.9 11.7 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)