Motif ID: E2f6

Z-value: 1.450


Transcription factors associated with E2f6:

Gene SymbolEntrez IDGene Name
E2f6 ENSMUSG00000057469.7 E2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f6mm10_v2_chr12_+_16810940_168109780.782.0e-13Click!


Activity profile for motif E2f6.

activity profile for motif E2f6


Sorted Z-values histogram for motif E2f6

Sorted Z-values for motif E2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_98004695 10.113 ENSMUST00000023123.8
Col2a1
collagen, type II, alpha 1
chr19_-_45742873 9.626 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
Fgf8


fibroblast growth factor 8


chr7_-_38107490 9.203 ENSMUST00000108023.3
Ccne1
cyclin E1
chr15_-_98004634 8.826 ENSMUST00000131560.1
ENSMUST00000088355.5
Col2a1

collagen, type II, alpha 1

chrX_-_141725181 8.668 ENSMUST00000067841.7
Irs4
insulin receptor substrate 4
chr17_-_35516780 8.400 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19


transcription factor 19


chr7_+_102441685 8.311 ENSMUST00000033283.9
Rrm1
ribonucleotide reductase M1
chr13_-_29984219 8.081 ENSMUST00000146092.1
E2f3
E2F transcription factor 3
chr13_+_48261427 8.008 ENSMUST00000021810.1
Id4
inhibitor of DNA binding 4
chr13_-_111808938 7.702 ENSMUST00000109267.2
Map3k1
mitogen-activated protein kinase kinase kinase 1
chr12_-_56536895 7.357 ENSMUST00000001536.8
Nkx2-1
NK2 homeobox 1
chr2_-_172940299 7.257 ENSMUST00000009143.7
Bmp7
bone morphogenetic protein 7
chr2_+_71389239 6.877 ENSMUST00000028408.2
Hat1
histone aminotransferase 1
chr11_+_82388900 6.860 ENSMUST00000054245.4
ENSMUST00000092852.2
Tmem132e

transmembrane protein 132E

chr4_-_11386757 6.848 ENSMUST00000108313.1
ENSMUST00000108311.2
Esrp1

epithelial splicing regulatory protein 1

chr2_-_64097994 6.670 ENSMUST00000131615.2
Fign
fidgetin
chr7_+_13278778 6.663 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
Lig1


ligase I, DNA, ATP-dependent


chrX_-_60893430 6.653 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr11_-_102946688 6.465 ENSMUST00000057849.5
C1ql1
complement component 1, q subcomponent-like 1
chrX_+_142681398 6.441 ENSMUST00000112889.1
ENSMUST00000101198.2
ENSMUST00000112891.1
ENSMUST00000087333.2
Tmem164



transmembrane protein 164




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 459 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 30.4 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.9 26.3 GO:0006270 DNA replication initiation(GO:0006270)
1.4 23.1 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.6 14.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.3 13.9 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
1.7 13.4 GO:0044027 hypermethylation of CpG island(GO:0044027)
3.2 12.6 GO:0015888 thiamine transport(GO:0015888)
0.7 12.3 GO:0061029 eyelid development in camera-type eye(GO:0061029)
4.1 12.2 GO:0030421 defecation(GO:0030421)
2.8 11.3 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
3.6 10.8 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
3.6 10.8 GO:0072180 mesenchymal cell proliferation involved in ureteric bud development(GO:0072138) mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
1.7 9.9 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
2.0 9.8 GO:0006348 chromatin silencing at telomere(GO:0006348)
4.8 9.6 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
2.4 9.6 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.4 9.6 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.4 9.6 GO:0060441 epithelial tube branching involved in lung morphogenesis(GO:0060441)
0.9 9.2 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.3 9.1 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 23.6 GO:0005730 nucleolus(GO:0005730)
1.7 22.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 19.7 GO:0005667 transcription factor complex(GO:0005667)
3.8 19.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.4 15.1 GO:0005657 replication fork(GO:0005657)
0.1 14.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 13.8 GO:0005884 actin filament(GO:0005884)
0.3 13.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 12.7 GO:0005844 polysome(GO:0005844)
0.5 12.3 GO:0001741 XY body(GO:0001741)
0.2 11.9 GO:0032432 actin filament bundle(GO:0032432)
0.7 10.6 GO:0042555 MCM complex(GO:0042555)
0.1 9.7 GO:0031526 brush border membrane(GO:0031526)
0.5 9.5 GO:0030894 replisome(GO:0030894)
0.1 8.9 GO:0016605 PML body(GO:0016605)
0.4 8.6 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.5 8.5 GO:0071564 npBAF complex(GO:0071564)
1.4 8.4 GO:0044294 dendritic growth cone(GO:0044294)
0.2 8.0 GO:0016592 mediator complex(GO:0016592)
0.5 7.9 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 266 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 31.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.3 31.0 GO:0005178 integrin binding(GO:0005178)
1.4 21.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
3.8 19.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5 16.6 GO:0071837 HMG box domain binding(GO:0071837)
0.3 14.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.7 14.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 14.2 GO:0001047 core promoter binding(GO:0001047)
0.1 14.1 GO:0003729 mRNA binding(GO:0003729)
1.7 13.7 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
4.2 12.6 GO:0015234 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.4 12.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.4 12.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 10.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 10.3 GO:0070063 RNA polymerase binding(GO:0070063)
0.2 10.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.7 10.2 GO:0043426 MRF binding(GO:0043426)
0.1 10.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 9.7 GO:0005109 frizzled binding(GO:0005109)
3.2 9.6 GO:0097108 hedgehog family protein binding(GO:0097108)