Motif ID: E2f7

Z-value: 1.296


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.504.6e-05Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 12.803 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3037111 12.755 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3025417 11.496 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr7_-_116308241 11.431 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr9_+_3015654 9.660 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3017408 9.553 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr4_+_108579445 7.468 ENSMUST00000102744.3
 Orc1
origin recognition complex, subunit 1
chr12_+_24708984 7.299 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr10_+_3973086 6.026 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr11_+_102248842 5.785 ENSMUST00000100392.4
 BC030867
cDNA sequence BC030867
chr12_+_24708241 5.663 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr13_-_100775844 5.594 ENSMUST00000075550.3
 Cenph
centromere protein H
chr10_-_69352886 5.402 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr15_+_102296256 4.932 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr19_-_41206774 4.842 ENSMUST00000025986.7
ENSMUST00000169941.1
 Tll2

tolloid-like 2

chr6_-_67037399 4.838 ENSMUST00000043098.6
 Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr8_+_75109528 4.712 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr3_+_108383829 4.293 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
 Psrc1


proline/serine-rich coiled-coil 1


chr14_-_20388822 3.919 ENSMUST00000022345.6
 Dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr2_-_157204483 3.828 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 13.0 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
1.9 11.4 GO:0045218 zonula adherens maintenance(GO:0045218)
1.9 7.5 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.5 7.0 GO:0051382 kinetochore assembly(GO:0051382)
1.2 6.0 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.5 6.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.5 4.9 GO:1901970 positive regulation of mitotic sister chromatid separation(GO:1901970)
1.0 4.8 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.4 4.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 4.7 GO:0006270 DNA replication initiation(GO:0006270)
0.5 4.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.2 4.3 GO:0060236 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.1 4.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 3.8 GO:0090166 Golgi disassembly(GO:0090166)
0.1 3.8 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.5 3.6 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.1 3.6 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.2 3.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
1.1 3.2 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.1 3.1 GO:0044342 type B pancreatic cell proliferation(GO:0044342)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 13.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.0 11.4 GO:0005915 zonula adherens(GO:0005915)
1.3 10.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 10.3 GO:0072686 mitotic spindle(GO:0072686)
0.5 7.5 GO:0042555 MCM complex(GO:0042555)
0.2 7.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 5.6 GO:0000922 spindle pole(GO:0000922)
0.0 3.7 GO:0000776 kinetochore(GO:0000776)
0.2 3.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.8 3.2 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.8 2.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.8 2.3 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 2.2 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 2.1 GO:0000786 nucleosome(GO:0000786)
0.4 2.0 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.4 2.0 GO:0001651 dense fibrillar component(GO:0001651) granular component(GO:0001652)
0.1 1.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.8 GO:0009925 basal plasma membrane(GO:0009925)
0.2 1.5 GO:0005638 lamin filament(GO:0005638)
0.2 1.4 GO:0000444 MIS12/MIND type complex(GO:0000444)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 13.7 GO:0070097 delta-catenin binding(GO:0070097)
2.6 13.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.0 7.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 7.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 6.6 GO:0001047 core promoter binding(GO:0001047)
1.5 6.0 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.3 5.9 GO:0035173 histone kinase activity(GO:0035173)
0.1 5.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 4.7 GO:0008017 microtubule binding(GO:0008017)
0.0 4.4 GO:0003682 chromatin binding(GO:0003682)
0.7 4.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.6 3.8 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.2 3.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.9 3.7 GO:0043515 kinetochore binding(GO:0043515)
0.0 3.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.3 GO:0042393 histone binding(GO:0042393)
0.8 3.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 3.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 2.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 2.9 GO:0031072 heat shock protein binding(GO:0031072)