Motif ID: E2f8

Z-value: 1.881


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.922.4e-25Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

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Top targets:


Showing 1 to 20 of 94 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_75109528 21.791 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr12_+_24708984 20.153 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr17_+_56040350 19.652 ENSMUST00000002914.8
 Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr17_+_56303321 18.744 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr9_-_36726374 17.752 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr6_-_94700137 17.189 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr17_+_56303396 15.634 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr1_-_128359610 15.613 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr12_+_24708241 15.422 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr7_-_115824699 14.968 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr16_-_18811615 14.826 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr11_+_98907801 14.435 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr5_+_123749696 14.211 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr7_-_48881032 13.777 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr7_-_48881596 11.979 ENSMUST00000119223.1
 E2f8
E2F transcription factor 8
chr11_-_101785252 11.972 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr11_-_89302545 11.951 ENSMUST00000061728.3
 Nog
noggin
chr10_-_21160925 11.925 ENSMUST00000020158.6
 Myb
myeloblastosis oncogene
chr2_+_163054682 11.627 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr6_-_88898664 10.941 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 55.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
1.6 36.2 GO:0006270 DNA replication initiation(GO:0006270)
3.6 35.6 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
2.7 35.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
8.6 25.8 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
2.5 24.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
3.7 22.4 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.7 19.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
5.7 17.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 16.4 GO:0006260 DNA replication(GO:0006260)
2.0 15.6 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.4 15.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
4.9 14.8 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
3.0 12.0 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
2.0 12.0 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.2 11.6 GO:1902850 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
2.2 11.2 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
3.5 10.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 9.9 GO:0030010 establishment of cell polarity(GO:0030010)
0.5 9.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 73.2 GO:0005657 replication fork(GO:0005657)
3.9 58.6 GO:0042555 MCM complex(GO:0042555)
0.1 46.4 GO:0005667 transcription factor complex(GO:0005667)
7.1 35.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.7 20.7 GO:0005721 pericentric heterochromatin(GO:0005721)
0.9 20.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
6.6 19.7 GO:0033186 CAF-1 complex(GO:0033186)
2.6 15.6 GO:0005663 DNA replication factor C complex(GO:0005663)
2.2 15.6 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
4.9 14.8 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
4.7 14.2 GO:1990423 RZZ complex(GO:1990423)
0.1 13.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
2.3 11.6 GO:0031523 Myb complex(GO:0031523)
0.4 11.5 GO:0051233 spindle midzone(GO:0051233)
1.8 9.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.7 8.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 7.9 GO:0032590 dendrite membrane(GO:0032590)
0.7 7.6 GO:0001673 male germ cell nucleus(GO:0001673)
1.4 6.8 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 5.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.9 47.6 GO:0003688 DNA replication origin binding(GO:0003688)
7.1 35.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
11.5 34.4 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.2 25.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 24.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
3.4 23.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 23.3 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 20.7 GO:0004386 helicase activity(GO:0004386)
2.5 19.7 GO:0070087 chromo shadow domain binding(GO:0070087)
0.2 19.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.7 18.9 GO:0017025 TBP-class protein binding(GO:0017025)
5.9 17.8 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
5.2 15.6 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
1.4 15.6 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.4 12.8 GO:0032452 histone demethylase activity(GO:0032452)
0.1 12.2 GO:0003697 single-stranded DNA binding(GO:0003697)
1.7 10.4 GO:0052630 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.2 10.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.4 9.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 8.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)