Motif ID: E2f8

Z-value: 1.881


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.922.4e-25Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_75109528 21.791 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr12_+_24708984 20.153 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr17_+_56040350 19.652 ENSMUST00000002914.8
 Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr17_+_56303321 18.744 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr9_-_36726374 17.752 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr6_-_94700137 17.189 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr17_+_56303396 15.634 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr1_-_128359610 15.613 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr12_+_24708241 15.422 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr7_-_115824699 14.968 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr16_-_18811615 14.826 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr11_+_98907801 14.435 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr5_+_123749696 14.211 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr7_-_48881032 13.777 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr7_-_48881596 11.979 ENSMUST00000119223.1
 E2f8
E2F transcription factor 8
chr11_-_101785252 11.972 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr11_-_89302545 11.951 ENSMUST00000061728.3
 Nog
noggin
chr10_-_21160925 11.925 ENSMUST00000020158.6
 Myb
myeloblastosis oncogene
chr2_+_163054682 11.627 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr6_-_88898664 10.941 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr19_+_38931008 10.745 ENSMUST00000145051.1
 Hells
helicase, lymphoid specific
chr10_+_128015157 10.413 ENSMUST00000178041.1
ENSMUST00000026461.7
 Prim1

DNA primase, p49 subunit

chr19_+_38930909 9.970 ENSMUST00000025965.5
 Hells
helicase, lymphoid specific
chr6_+_117916981 9.946 ENSMUST00000179478.1
 Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr5_+_111581422 9.626 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr16_-_46496955 9.590 ENSMUST00000023335.6
ENSMUST00000023334.8
 Pvrl3

poliovirus receptor-related 3

chr4_+_132768325 9.556 ENSMUST00000102561.4
 Rpa2
replication protein A2
chr7_+_110122299 9.199 ENSMUST00000033326.8
 Wee1
WEE 1 homolog 1 (S. pombe)
chr5_-_33652296 9.056 ENSMUST00000151081.1
ENSMUST00000101354.3
 Slbp

stem-loop binding protein

chr16_-_15637277 9.042 ENSMUST00000023353.3
 Mcm4
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr6_+_117917281 8.948 ENSMUST00000180020.1
ENSMUST00000177570.1
 Hnrnpf

heterogeneous nuclear ribonucleoprotein F

chr16_-_46496772 8.823 ENSMUST00000149901.1
ENSMUST00000096052.2
 Pvrl3

poliovirus receptor-related 3

chr11_+_26387194 8.646 ENSMUST00000109509.1
ENSMUST00000136830.1
 Fancl

Fanconi anemia, complementation group L

chr2_-_34913976 8.151 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr5_-_65335597 7.902 ENSMUST00000172660.1
ENSMUST00000172732.1
ENSMUST00000031092.8
 Rfc1


replication factor C (activator 1) 1


chr5_-_65335564 7.681 ENSMUST00000172780.1
 Rfc1
replication factor C (activator 1) 1
chr9_+_103305156 7.602 ENSMUST00000035164.3
 Topbp1
topoisomerase (DNA) II binding protein 1
chr2_-_157204483 7.488 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr13_+_94875600 6.941 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr4_-_129189600 6.829 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr2_+_145785980 6.734 ENSMUST00000110005.1
ENSMUST00000094480.4
 Rin2

Ras and Rab interactor 2

chr5_-_33652339 6.561 ENSMUST00000075670.6
 Slbp
stem-loop binding protein
chr13_+_44731281 6.463 ENSMUST00000174086.1
 Jarid2
jumonji, AT rich interactive domain 2
chr15_+_55557399 6.356 ENSMUST00000022998.7
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr13_+_44731265 6.348 ENSMUST00000173246.1
 Jarid2
jumonji, AT rich interactive domain 2
chr4_-_129189512 6.212 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
 S100pbp


S100P binding protein


chr1_+_131910458 6.193 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr4_-_129189646 6.193 ENSMUST00000106059.1
 S100pbp
S100P binding protein
chr15_+_78926720 6.122 ENSMUST00000089377.5
 Lgals1
lectin, galactose binding, soluble 1
chr16_+_10835046 6.035 ENSMUST00000037913.8
 Rmi2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr12_+_110279228 5.748 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr8_+_40926220 5.507 ENSMUST00000034004.9
 Pdgfrl
platelet-derived growth factor receptor-like
chr7_-_44548733 5.178 ENSMUST00000145956.1
ENSMUST00000049343.8
 Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr13_+_19623163 5.015 ENSMUST00000002883.5
 Sfrp4
secreted frizzled-related protein 4
chr15_+_55557575 4.877 ENSMUST00000170046.1
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr5_+_129020069 4.838 ENSMUST00000031383.7
ENSMUST00000111343.1
 Ran

RAN, member RAS oncogene family

chr6_+_35177386 4.807 ENSMUST00000043815.9
 Nup205
nucleoporin 205
chr16_-_18248697 4.659 ENSMUST00000115645.3
 Ranbp1
RAN binding protein 1
chr5_+_137787769 4.499 ENSMUST00000035852.7
 Zcwpw1
zinc finger, CW type with PWWP domain 1
chr2_-_84743655 4.468 ENSMUST00000181711.1
 Gm19426
predicted gene, 19426
chr6_+_35177610 4.409 ENSMUST00000170234.1
 Nup205
nucleoporin 205
chr7_+_102065713 4.383 ENSMUST00000094129.2
ENSMUST00000094130.2
ENSMUST00000084843.3
 Trpc2


transient receptor potential cation channel, subfamily C, member 2


chr5_+_150673739 3.857 ENSMUST00000016569.4
ENSMUST00000038900.8
 Pds5b

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

chr2_-_154569720 3.596 ENSMUST00000000894.5
 E2f1
E2F transcription factor 1
chr7_+_102065485 3.468 ENSMUST00000106950.1
ENSMUST00000146450.1
 Trpc2

transient receptor potential cation channel, subfamily C, member 2

chrX_-_73716145 3.290 ENSMUST00000002091.5
 Bcap31
B cell receptor associated protein 31
chr2_-_154569845 3.157 ENSMUST00000103145.4
 E2f1
E2F transcription factor 1
chr10_+_19356558 2.898 ENSMUST00000053225.5
 Olig3
oligodendrocyte transcription factor 3
chr10_+_116301374 2.667 ENSMUST00000092167.5
 Ptprb
protein tyrosine phosphatase, receptor type, B
chr6_-_87851011 2.654 ENSMUST00000113617.1
 Cnbp
cellular nucleic acid binding protein
chr3_-_127553233 2.564 ENSMUST00000029588.5
 Larp7
La ribonucleoprotein domain family, member 7
chrX_+_73716712 2.409 ENSMUST00000114461.2
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr10_-_128525859 2.192 ENSMUST00000026427.6
 Esyt1
extended synaptotagmin-like protein 1
chr9_-_35116804 2.185 ENSMUST00000034537.6
 St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr2_-_18048784 1.896 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr9_-_50659780 1.636 ENSMUST00000034567.3
 Dlat
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
chr11_+_77462325 1.502 ENSMUST00000102493.1
 Coro6
coronin 6
chr6_+_29348069 1.492 ENSMUST00000173216.1
ENSMUST00000031779.10
ENSMUST00000090481.7
 Calu


calumenin


chr6_+_38551786 1.487 ENSMUST00000161227.1
 Luc7l2
LUC7-like 2 (S. cerevisiae)
chr8_-_109737714 1.369 ENSMUST00000093162.3
 Atxn1l
ataxin 1-like
chr7_-_128740471 1.216 ENSMUST00000119081.1
ENSMUST00000057557.7
 Mcmbp

MCM (minichromosome maintenance deficient) binding protein

chrX_+_73716577 1.152 ENSMUST00000002084.7
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr5_+_135187251 1.080 ENSMUST00000002825.5
 Baz1b
bromodomain adjacent to zinc finger domain, 1B
chr11_-_21572193 1.025 ENSMUST00000102874.4
 Mdh1
malate dehydrogenase 1, NAD (soluble)
chr10_+_42860348 0.975 ENSMUST00000063063.7
 Scml4
sex comb on midleg-like 4 (Drosophila)
chr11_+_88047693 0.866 ENSMUST00000079866.4
 Srsf1
serine/arginine-rich splicing factor 1
chr17_+_33909577 0.743 ENSMUST00000170075.2
 Daxx
Fas death domain-associated protein
chr11_+_21572221 0.714 ENSMUST00000020568.3
ENSMUST00000131135.1
 Wdpcp

WD repeat containing planar cell polarity effector

chr1_-_168431695 0.627 ENSMUST00000176790.1
 Pbx1
pre B cell leukemia homeobox 1
chr15_-_98093245 0.503 ENSMUST00000180657.1
 Senp1
SUMO1/sentrin specific peptidase 1
chr17_+_33909481 0.444 ENSMUST00000173626.1
ENSMUST00000174541.1
 Daxx

Fas death domain-associated protein

chr10_+_84917616 0.412 ENSMUST00000038523.7
ENSMUST00000095385.3
 Ric8b

resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)

chr15_-_55557748 0.328 ENSMUST00000172387.1
 Mrpl13
mitochondrial ribosomal protein L13
chrX_-_70477170 0.041 ENSMUST00000101506.3
ENSMUST00000114630.2
 BC023829

cDNA sequence BC023829


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.6 25.8 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
5.7 17.2 GO:0032474 otolith morphogenesis(GO:0032474)
4.9 14.8 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
3.7 22.4 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
3.7 55.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
3.6 35.6 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
3.5 10.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
3.0 12.0 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
2.7 35.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
2.5 24.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
2.3 6.8 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
2.2 11.2 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
2.0 12.0 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
2.0 15.6 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.7 5.0 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
1.6 36.2 GO:0006270 DNA replication initiation(GO:0006270)
1.6 7.9 GO:0002121 inter-male aggressive behavior(GO:0002121) response to pheromone(GO:0019236)
1.4 15.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.2 6.1 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
1.2 3.6 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
1.2 8.2 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
1.1 3.3 GO:1904154 protein localization to endoplasmic reticulum exit site(GO:0070973) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
1.0 4.8 GO:1902570 protein localization to nucleolus(GO:1902570)
1.0 5.7 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.9 5.2 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.8 9.2 GO:0000059 protein import into nucleus, docking(GO:0000059)
0.7 19.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.6 2.9 GO:0097475 motor neuron migration(GO:0097475) spinal cord motor neuron migration(GO:0097476)
0.5 9.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.5 6.9 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.4 6.2 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.3 7.6 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.2 1.6 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.2 2.6 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.2 11.6 GO:1902850 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.2 1.4 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.2 1.0 GO:0006108 malate metabolic process(GO:0006108)
0.2 7.5 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.2 3.9 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 2.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.5 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 8.6 GO:0098792 xenophagy(GO:0098792)
0.1 1.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 16.4 GO:0006260 DNA replication(GO:0006260)
0.1 0.5 GO:0030578 PML body organization(GO:0030578)
0.1 6.9 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.1 9.9 GO:0030010 establishment of cell polarity(GO:0030010)
0.1 1.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 4.6 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 6.6 GO:0006897 endocytosis(GO:0006897)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 35.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
6.6 19.7 GO:0033186 CAF-1 complex(GO:0033186)
4.9 14.8 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
4.7 14.2 GO:1990423 RZZ complex(GO:1990423)
3.9 58.6 GO:0042555 MCM complex(GO:0042555)
2.6 15.6 GO:0005663 DNA replication factor C complex(GO:0005663)
2.3 11.6 GO:0031523 Myb complex(GO:0031523)
2.2 15.6 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
1.8 9.2 GO:0044611 nuclear pore inner ring(GO:0044611)
1.7 5.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.6 4.8 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
1.4 6.8 GO:0035189 Rb-E2F complex(GO:0035189)
1.1 73.2 GO:0005657 replication fork(GO:0005657)
0.9 20.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.7 20.7 GO:0005721 pericentric heterochromatin(GO:0005721)
0.7 7.6 GO:0001673 male germ cell nucleus(GO:0001673)
0.7 8.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.7 3.3 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.5 1.6 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.4 4.7 GO:1904115 axon cytoplasm(GO:1904115)
0.4 11.5 GO:0051233 spindle midzone(GO:0051233)
0.2 7.9 GO:0032590 dendrite membrane(GO:0032590)
0.2 2.2 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 3.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 1.5 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 13.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 46.4 GO:0005667 transcription factor complex(GO:0005667)
0.1 1.5 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 0.7 GO:0044447 axoneme part(GO:0044447)
0.0 2.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 5.2 GO:0000776 kinetochore(GO:0000776)
0.0 1.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.5 GO:0001741 XY body(GO:0001741)
0.0 5.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
11.5 34.4 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
7.1 35.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
5.9 47.6 GO:0003688 DNA replication origin binding(GO:0003688)
5.9 17.8 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
5.2 15.6 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
3.4 23.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
2.5 19.7 GO:0070087 chromo shadow domain binding(GO:0070087)
2.0 6.1 GO:0005534 galactose binding(GO:0005534)
1.7 10.4 GO:0052630 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
1.4 15.6 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.0 4.8 GO:0070883 importin-alpha family protein binding(GO:0061676) pre-miRNA binding(GO:0070883)
0.7 5.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.7 7.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.7 3.6 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.7 18.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.6 6.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.5 24.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.4 7.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.4 9.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 12.8 GO:0032452 histone demethylase activity(GO:0032452)
0.3 2.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.3 1.6 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.2 10.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 3.3 GO:0042288 MHC class I protein binding(GO:0042288)
0.2 5.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 19.2 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 1.0 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.2 25.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 0.5 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.2 20.7 GO:0004386 helicase activity(GO:0004386)
0.1 12.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 4.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 7.5 GO:0019955 cytokine binding(GO:0019955)
0.1 2.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.7 GO:0035064 methylated histone binding(GO:0035064)
0.0 8.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.5 GO:0050681 androgen receptor binding(GO:0050681)
0.0 23.3 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 2.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 5.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.4 GO:0003682 chromatin binding(GO:0003682)