Motif ID: Egr1

Z-value: 3.032


Transcription factors associated with Egr1:

Gene SymbolEntrez IDGene Name
Egr1 ENSMUSG00000038418.7 Egr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr1mm10_v2_chr18_+_34861200_34861215-0.066.6e-01Click!


Activity profile for motif Egr1.

activity profile for motif Egr1


Sorted Z-values histogram for motif Egr1

Sorted Z-values for motif Egr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065538 83.567 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr11_+_98348404 38.178 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr4_+_127169131 32.537 ENSMUST00000046659.7
 Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr5_+_137553517 30.834 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr5_-_139129662 28.376 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr5_-_139130159 27.527 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr14_-_33447142 27.239 ENSMUST00000111944.3
ENSMUST00000022504.5
ENSMUST00000111945.2
 Mapk8


mitogen-activated protein kinase 8


chr11_-_6065737 26.359 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr3_-_89322883 25.901 ENSMUST00000029673.5
 Efna3
ephrin A3
chr3_+_54156039 24.978 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr3_+_28263205 24.860 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase
chr6_-_126645784 22.702 ENSMUST00000055168.3
 Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chrX_-_20920911 21.166 ENSMUST00000081893.6
ENSMUST00000115345.1
 Syn1

synapsin I

chr4_+_124657646 20.672 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr5_+_32136458 20.638 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr18_-_34931931 20.493 ENSMUST00000180351.1
 Etf1
eukaryotic translation termination factor 1
chr8_-_84800024 20.134 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr11_-_98329641 19.983 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr7_+_73740277 19.144 ENSMUST00000107456.2
 Fam174b
family with sequence similarity 174, member B
chr7_-_45370559 19.097 ENSMUST00000003971.7
 Lin7b
lin-7 homolog B (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
36.6 109.9 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
4.5 53.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.1 51.0 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
8.8 44.2 GO:0007256 activation of JNKK activity(GO:0007256)
12.7 38.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
2.2 35.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 34.4 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
2.2 30.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 29.6 GO:0000209 protein polyubiquitination(GO:0000209)
1.6 29.3 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.1 28.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
9.2 27.6 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
6.8 27.2 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
4.4 26.1 GO:0032796 uropod organization(GO:0032796)
1.9 25.0 GO:0001956 positive regulation of neurotransmitter secretion(GO:0001956)
0.6 23.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
7.6 22.7 GO:0050975 sensory perception of touch(GO:0050975)
3.1 21.5 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.2 20.7 GO:0016579 protein deubiquitination(GO:0016579)
0.5 20.6 GO:0032355 response to estradiol(GO:0032355)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 114.4 GO:0045211 postsynaptic membrane(GO:0045211)
3.4 109.9 GO:0051233 spindle midzone(GO:0051233)
0.2 82.5 GO:0043025 neuronal cell body(GO:0043025)
0.4 59.0 GO:0055037 recycling endosome(GO:0055037)
4.4 57.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.9 56.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.9 49.0 GO:0034704 calcium channel complex(GO:0034704)
1.6 37.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.9 34.9 GO:0048786 presynaptic active zone(GO:0048786)
2.2 32.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 32.0 GO:0000139 Golgi membrane(GO:0000139)
0.2 29.1 GO:0005769 early endosome(GO:0005769)
2.3 27.6 GO:0097449 astrocyte projection(GO:0097449)
0.8 27.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
3.4 27.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 26.5 GO:0031225 anchored component of membrane(GO:0031225)
1.1 26.4 GO:0001891 phagocytic cup(GO:0001891)
1.3 25.4 GO:0016514 SWI/SNF complex(GO:0016514)
1.2 22.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 20.5 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 160 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.0 120.7 GO:0043274 phospholipase binding(GO:0043274)
5.1 55.9 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.8 50.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 43.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.3 39.6 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
12.7 38.2 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
2.7 38.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.5 37.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
3.7 36.7 GO:0019870 potassium channel inhibitor activity(GO:0019870)
3.4 27.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
1.3 26.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
2.6 26.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.6 25.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.3 25.7 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 25.6 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
2.1 25.0 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.7 24.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.4 22.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
1.3 21.5 GO:0050253 prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) retinyl-palmitate esterase activity(GO:0050253) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
5.1 20.5 GO:0016149 translation release factor activity, codon specific(GO:0016149)