Motif ID: Egr3

Z-value: 0.645


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_70077445-0.331.2e-02Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Showing 1 to 20 of 113 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_110061319 5.670 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr7_-_119184374 3.060 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr7_+_144896523 2.858 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr6_-_49214954 2.585 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr10_+_69534208 2.140 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
 Ank3





ankyrin 3, epithelial





chr17_+_87282880 2.107 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr10_+_69533803 2.089 ENSMUST00000182155.1
ENSMUST00000183169.1
ENSMUST00000183148.1
 Ank3


ankyrin 3, epithelial


chr13_-_41847626 2.010 ENSMUST00000121404.1
 Adtrp
androgen dependent TFPI regulating protein
chr9_-_55048544 1.931 ENSMUST00000034854.6
 Chrnb4
cholinergic receptor, nicotinic, beta polypeptide 4
chr9_-_58204310 1.926 ENSMUST00000114144.2
 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr11_+_98937669 1.907 ENSMUST00000107475.2
ENSMUST00000068133.3
 Rara

retinoic acid receptor, alpha

chr10_+_69533761 1.862 ENSMUST00000182884.1
 Ank3
ankyrin 3, epithelial
chrX_-_162159717 1.824 ENSMUST00000087085.3
 Nhs
Nance-Horan syndrome (human)
chr2_-_65529275 1.798 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr13_-_41847482 1.693 ENSMUST00000072012.3
 Adtrp
androgen dependent TFPI regulating protein
chr8_+_62951361 1.635 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr17_-_87282793 1.603 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr10_-_29144194 1.594 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr3_+_129213920 1.494 ENSMUST00000042587.10
 Pitx2
paired-like homeodomain transcription factor 2
chr5_-_138279960 1.441 ENSMUST00000014089.7
ENSMUST00000161827.1
 Gpc2

glypican 2 (cerebroglycan)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 7.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 3.1 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.7 2.9 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0 2.7 GO:0051028 mRNA transport(GO:0051028)
0.3 2.3 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 2.1 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.2 2.0 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.6 1.9 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.6 1.9 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 1.9 GO:0045773 positive regulation of axon extension(GO:0045773)
0.4 1.8 GO:0046684 response to pyrethroid(GO:0046684)
0.0 1.8 GO:0002088 lens development in camera-type eye(GO:0002088)
0.4 1.6 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
0.2 1.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 1.5 GO:0055009 extraocular skeletal muscle development(GO:0002074) atrial cardiac muscle tissue development(GO:0003228) pulmonary myocardium development(GO:0003350) subthalamus development(GO:0021539) subthalamic nucleus development(GO:0021763) atrial cardiac muscle tissue morphogenesis(GO:0055009) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.1 1.4 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.4 1.3 GO:0010757 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) negative regulation of plasminogen activation(GO:0010757) regulation of vascular wound healing(GO:0061043) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.2 1.3 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.0 1.2 GO:0098792 xenophagy(GO:0098792)
0.2 1.1 GO:1900028 negative regulation of ruffle assembly(GO:1900028)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 2.3 GO:0031209 SCAR complex(GO:0031209)
0.1 2.0 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.2 1.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.8 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.3 1.6 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 1.4 GO:0032587 ruffle membrane(GO:0032587)
0.3 1.3 GO:0042583 chromaffin granule(GO:0042583)
0.0 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.5 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.5 GO:0031430 M band(GO:0031430)
0.0 0.5 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.4 GO:0031417 NatC complex(GO:0031417)
0.1 0.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 4.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 3.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 2.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 2.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.3 2.0 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.2 1.9 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 1.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 1.8 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.6 GO:0030957 Tat protein binding(GO:0030957)
0.1 1.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.1 GO:0005522 profilin binding(GO:0005522)
0.1 1.0 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 1.0 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 1.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)