Motif ID: Emx1_Emx2

Z-value: 0.626

Transcription factors associated with Emx1_Emx2:

Gene SymbolEntrez IDGene Name
Emx1 ENSMUSG00000033726.8 Emx1
Emx2 ENSMUSG00000043969.4 Emx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Emx1mm10_v2_chr6_+_85187438_851875100.621.3e-07Click!
Emx2mm10_v2_chr19_+_59458372_59458450-0.392.4e-03Click!


Activity profile for motif Emx1_Emx2.

activity profile for motif Emx1_Emx2


Sorted Z-values histogram for motif Emx1_Emx2

Sorted Z-values for motif Emx1_Emx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Emx1_Emx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 158 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_82505749 9.563 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505274 8.583 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr4_-_82505707 8.429 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr1_-_158356258 4.164 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr10_+_81257277 3.258 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr9_-_20728219 3.126 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr3_+_127633134 2.967 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr17_-_36032682 2.570 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr10_+_90071095 2.522 ENSMUST00000183109.1
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_156392829 2.518 ENSMUST00000088578.2
 2900097C17Rik
RIKEN cDNA 2900097C17 gene
chr16_-_97170707 2.365 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr17_-_31636631 2.315 ENSMUST00000135425.1
ENSMUST00000151718.1
ENSMUST00000155814.1
 Cbs


cystathionine beta-synthase


chr1_+_32172711 2.262 ENSMUST00000027226.5
 Khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr4_+_118961578 1.954 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr16_-_63864114 1.904 ENSMUST00000064405.6
 Epha3
Eph receptor A3
chr15_+_99006056 1.887 ENSMUST00000079818.3
 Gm8973
predicted gene 8973
chr7_-_103827922 1.883 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr11_-_42000284 1.880 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr9_+_34904913 1.569 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr1_+_93685574 1.519 ENSMUST00000027499.6
 Bok
BCL2-related ovarian killer protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.6 26.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 4.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 3.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3 3.1 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 3.0 GO:0021954 central nervous system neuron development(GO:0021954)
0.9 2.6 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.2 2.5 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.8 2.4 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.8 2.3 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.3 2.3 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.6 1.9 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.2 1.9 GO:0071420 cellular response to histamine(GO:0071420)
0.0 1.7 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.8 1.6 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
0.4 1.5 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 1.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.3 1.3 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.2 1.2 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.2 1.2 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.4 1.1 GO:0031038 myosin II filament organization(GO:0031038) regulation of myosin II filament organization(GO:0043519)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 26.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 4.2 GO:0030425 dendrite(GO:0030425)
0.0 3.4 GO:0030426 growth cone(GO:0030426)
0.1 3.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.2 2.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.5 1.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.6 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.6 GO:0016605 PML body(GO:0016605)
0.0 1.5 GO:0005814 centriole(GO:0005814)
0.4 1.2 GO:0043512 inhibin A complex(GO:0043512)
0.1 1.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 0.8 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.8 GO:0035253 ciliary rootlet(GO:0035253)
0.2 0.7 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.1 0.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 26.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 3.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 3.0 GO:0070888 E-box binding(GO:0070888)
0.3 2.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 2.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.8 2.3 GO:0098809 nitrite reductase activity(GO:0098809)
0.1 2.3 GO:0008143 poly(A) binding(GO:0008143)
0.7 2.0 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.5 1.9 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.2 1.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 1.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 1.5 GO:0051400 BH domain binding(GO:0051400)
0.1 1.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 1.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 1.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 1.0 GO:0052630 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.1 0.8 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)