Motif ID: En2
Z-value: 0.488
Transcription factors associated with En2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
En2 | ENSMUSG00000039095.7 | En2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
En2 | mm10_v2_chr5_+_28165690_28165717 | -0.08 | 5.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.8 | GO:0050975 | sensory perception of touch(GO:0050975) |
0.8 | 2.3 | GO:1904339 | negative regulation of dopaminergic neuron differentiation(GO:1904339) |
0.5 | 1.5 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
0.5 | 1.5 | GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
0.4 | 2.9 | GO:0015808 | L-alanine transport(GO:0015808) |
0.4 | 2.6 | GO:0019532 | oxalate transport(GO:0019532) |
0.4 | 3.7 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
0.3 | 1.5 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
0.2 | 0.7 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
0.2 | 0.9 | GO:0032512 | regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
0.2 | 0.8 | GO:0072592 | regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592) |
0.2 | 1.2 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
0.2 | 1.6 | GO:0016198 | axon choice point recognition(GO:0016198) |
0.2 | 0.5 | GO:0060023 | soft palate development(GO:0060023) |
0.2 | 1.4 | GO:0050957 | equilibrioception(GO:0050957) |
0.2 | 0.6 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
0.1 | 1.7 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
0.1 | 1.4 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
0.1 | 0.8 | GO:0021814 | cell motility involved in cerebral cortex radial glia guided migration(GO:0021814) |
0.1 | 1.0 | GO:0071361 | cellular response to ethanol(GO:0071361) |
0.1 | 0.4 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
0.1 | 0.5 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
0.1 | 1.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.1 | 0.4 | GO:0097167 | circadian regulation of translation(GO:0097167) |
0.1 | 0.6 | GO:0046689 | response to mercury ion(GO:0046689) |
0.1 | 0.5 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
0.1 | 2.4 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
0.1 | 0.3 | GO:0061743 | motor learning(GO:0061743) |
0.1 | 0.5 | GO:0007021 | tubulin complex assembly(GO:0007021) |
0.1 | 0.4 | GO:0060178 | regulation of exocyst localization(GO:0060178) |
0.1 | 1.3 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
0.1 | 0.6 | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) |
0.1 | 0.7 | GO:0032570 | response to progesterone(GO:0032570) |
0.1 | 1.1 | GO:0061157 | mRNA destabilization(GO:0061157) |
0.1 | 0.4 | GO:0006551 | leucine metabolic process(GO:0006551) |
0.1 | 2.7 | GO:0051290 | protein heterotetramerization(GO:0051290) |
0.1 | 1.4 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
0.1 | 3.6 | GO:0015807 | L-amino acid transport(GO:0015807) |
0.1 | 0.9 | GO:0048305 | immunoglobulin secretion(GO:0048305) |
0.1 | 0.2 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
0.0 | 5.0 | GO:0006342 | chromatin silencing(GO:0006342) |
0.0 | 0.6 | GO:0043968 | histone H2A acetylation(GO:0043968) |
0.0 | 0.1 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
0.0 | 1.2 | GO:0007608 | sensory perception of smell(GO:0007608) |
0.0 | 0.6 | GO:0097178 | ruffle assembly(GO:0097178) |
0.0 | 0.8 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.0 | 0.7 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
0.0 | 0.4 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
0.0 | 0.3 | GO:0048199 | vesicle targeting, to, from or within Golgi(GO:0048199) |
0.0 | 0.3 | GO:0042761 | very long-chain fatty acid biosynthetic process(GO:0042761) |
0.0 | 0.3 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
0.0 | 0.3 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
0.0 | 0.5 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
0.0 | 0.4 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
0.0 | 0.4 | GO:0033194 | response to hydroperoxide(GO:0033194) |
0.0 | 0.1 | GO:0045144 | meiotic sister chromatid segregation(GO:0045144) meiotic sister chromatid cohesion(GO:0051177) |
0.0 | 0.4 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
0.0 | 1.6 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
0.0 | 0.9 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
0.0 | 0.6 | GO:1904030 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
0.0 | 0.6 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
0.0 | 0.4 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
0.0 | 0.1 | GO:0061055 | myotome development(GO:0061055) |
0.0 | 0.1 | GO:0034587 | piRNA metabolic process(GO:0034587) |
0.0 | 0.3 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
0.2 | 1.7 | GO:0071437 | invadopodium(GO:0071437) |
0.2 | 2.3 | GO:1990909 | Wnt signalosome(GO:1990909) |
0.1 | 4.8 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.1 | 2.8 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
0.1 | 0.8 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
0.1 | 0.7 | GO:0097524 | sperm plasma membrane(GO:0097524) |
0.1 | 1.6 | GO:0005614 | interstitial matrix(GO:0005614) |
0.1 | 1.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
0.1 | 1.6 | GO:0031527 | filopodium membrane(GO:0031527) |
0.1 | 0.8 | GO:0044327 | dendritic spine head(GO:0044327) |
0.1 | 0.6 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
0.1 | 2.0 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
0.1 | 3.8 | GO:0005882 | intermediate filament(GO:0005882) |
0.1 | 0.3 | GO:0044301 | climbing fiber(GO:0044301) |
0.1 | 0.5 | GO:0016272 | prefoldin complex(GO:0016272) |
0.1 | 0.6 | GO:0000812 | Swr1 complex(GO:0000812) |
0.1 | 2.3 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 3.7 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
0.0 | 0.4 | GO:0070688 | MLL5-L complex(GO:0070688) |
0.0 | 0.5 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.0 | 3.4 | GO:0070469 | respiratory chain(GO:0070469) |
0.0 | 0.5 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.0 | 1.4 | GO:0032420 | stereocilium(GO:0032420) |
0.0 | 0.4 | GO:0000124 | SAGA complex(GO:0000124) |
0.0 | 0.5 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 1.5 | GO:0031901 | early endosome membrane(GO:0031901) |
0.0 | 0.4 | GO:0036038 | MKS complex(GO:0036038) |
0.0 | 2.1 | GO:0072562 | blood microparticle(GO:0072562) |
0.0 | 0.3 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
0.0 | 1.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.0 | 0.6 | GO:0035145 | exon-exon junction complex(GO:0035145) |
0.0 | 0.2 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 0.3 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
0.0 | 0.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.0 | 1.1 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
0.0 | 0.6 | GO:0016363 | nuclear matrix(GO:0016363) |
0.0 | 0.1 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:0036004 | GAF domain binding(GO:0036004) |
0.5 | 3.7 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
0.4 | 2.9 | GO:0015180 | L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858) |
0.3 | 1.0 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
0.3 | 1.6 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
0.3 | 0.8 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
0.2 | 2.6 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
0.1 | 0.8 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.1 | 6.3 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.1 | 2.3 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
0.1 | 3.6 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
0.1 | 0.5 | GO:0071532 | ornithine decarboxylase inhibitor activity(GO:0008073) ankyrin repeat binding(GO:0071532) |
0.1 | 0.9 | GO:0043495 | protein anchor(GO:0043495) |
0.1 | 2.9 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.1 | 2.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
0.1 | 0.6 | GO:0015265 | urea channel activity(GO:0015265) |
0.1 | 1.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.1 | 2.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.1 | 0.6 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
0.1 | 0.4 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
0.1 | 1.5 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
0.1 | 0.7 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
0.1 | 1.6 | GO:0001968 | fibronectin binding(GO:0001968) |
0.0 | 0.4 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
0.0 | 1.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 1.4 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
0.0 | 0.3 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
0.0 | 0.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.0 | 0.6 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.0 | 4.1 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
0.0 | 0.4 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
0.0 | 0.3 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
0.0 | 0.3 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
0.0 | 0.8 | GO:0005507 | copper ion binding(GO:0005507) |
0.0 | 1.1 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
0.0 | 0.8 | GO:0048365 | Rac GTPase binding(GO:0048365) |
0.0 | 0.2 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
0.0 | 0.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.4 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.0 | 0.5 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.0 | 0.2 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
0.0 | 0.4 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 1.4 | GO:0047485 | protein N-terminus binding(GO:0047485) |