Motif ID: En2

Z-value: 0.488


Transcription factors associated with En2:

Gene SymbolEntrez IDGene Name
En2 ENSMUSG00000039095.7 En2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En2mm10_v2_chr5_+_28165690_28165717-0.085.7e-01Click!


Activity profile for motif En2.

activity profile for motif En2


Sorted Z-values histogram for motif En2

Sorted Z-values for motif En2



Network of associatons between targets according to the STRING database.



First level regulatory network of En2

PNG image of the network

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Top targets:


Showing 1 to 20 of 182 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_23574381 6.405 ENSMUST00000090776.4
 Hist1h2ad
histone cluster 1, H2ad
chr5_-_62766153 4.932 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_+_3397189 3.800 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr5_-_84417359 3.671 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr6_-_126645784 2.790 ENSMUST00000055168.3
 Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr2_+_116067213 2.539 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr16_+_38089001 2.303 ENSMUST00000023507.6
 Gsk3b
glycogen synthase kinase 3 beta
chr13_+_23544052 2.253 ENSMUST00000075558.2
 Hist1h3f
histone cluster 1, H3f
chr7_+_29071597 2.181 ENSMUST00000180926.1
 Gm26604
predicted gene, 26604
chr15_+_18818895 1.885 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr12_-_85151264 1.873 ENSMUST00000019379.7
 Rps6kl1
ribosomal protein S6 kinase-like 1
chr3_+_96268654 1.846 ENSMUST00000098843.2
 Hist2h3b
histone cluster 2, H3b
chr2_+_62664279 1.734 ENSMUST00000028257.2
 Gca
grancalcin
chr4_-_14621805 1.721 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr13_-_23574196 1.690 ENSMUST00000105106.1
 Hist1h2bf
histone cluster 1, H2bf
chr3_+_88207308 1.687 ENSMUST00000180582.1
 Gm3764
predicted gene 3764
chr16_-_42340595 1.634 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr16_+_45093611 1.609 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chrX_+_136741821 1.544 ENSMUST00000089350.4
 BC065397
cDNA sequence BC065397
chr12_-_84450944 1.525 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0006342 chromatin silencing(GO:0006342)
0.4 3.7 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 3.6 GO:0015807 L-amino acid transport(GO:0015807)
0.4 2.9 GO:0015808 L-alanine transport(GO:0015808)
0.9 2.8 GO:0050975 sensory perception of touch(GO:0050975)
0.1 2.7 GO:0051290 protein heterotetramerization(GO:0051290)
0.4 2.6 GO:0019532 oxalate transport(GO:0019532)
0.1 2.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.8 2.3 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.1 1.7 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 1.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 1.6 GO:0016198 axon choice point recognition(GO:0016198)
0.0 1.6 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.5 1.5 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.5 1.5 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.3 1.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.2 1.4 GO:0050957 equilibrioception(GO:0050957)
0.1 1.4 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 1.4 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 1.3 GO:0021796 cerebral cortex regionalization(GO:0021796)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 3.8 GO:0005882 intermediate filament(GO:0005882)
0.0 3.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.4 GO:0070469 respiratory chain(GO:0070469)
0.1 2.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 2.3 GO:1990909 Wnt signalosome(GO:1990909)
0.1 2.3 GO:0000786 nucleosome(GO:0000786)
0.0 2.1 GO:0072562 blood microparticle(GO:0072562)
0.1 2.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 1.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 1.7 GO:0071437 invadopodium(GO:0071437)
0.1 1.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.6 GO:0031527 filopodium membrane(GO:0031527)
0.5 1.5 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 1.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.4 GO:0032420 stereocilium(GO:0032420)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 0.8 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 0.8 GO:0044327 dendritic spine head(GO:0044327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 4.1 GO:0005057 receptor signaling protein activity(GO:0005057)
0.5 3.7 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 3.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.4 2.9 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.1 2.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 2.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 2.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 2.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 2.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 1.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 1.6 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 1.6 GO:0001968 fibronectin binding(GO:0001968)
0.5 1.5 GO:0036004 GAF domain binding(GO:0036004)
0.1 1.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.4 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 1.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.3 1.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)