Motif ID: Epas1_Bcl3

Z-value: 1.906

Transcription factors associated with Epas1_Bcl3:

Gene SymbolEntrez IDGene Name
Bcl3 ENSMUSG00000053175.10 Bcl3
Epas1 ENSMUSG00000024140.9 Epas1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Epas1mm10_v2_chr17_+_86753900_867539140.365.5e-03Click!


Activity profile for motif Epas1_Bcl3.

activity profile for motif Epas1_Bcl3


Sorted Z-values histogram for motif Epas1_Bcl3

Sorted Z-values for motif Epas1_Bcl3



Network of associatons between targets according to the STRING database.



First level regulatory network of Epas1_Bcl3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_127725392 23.805 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr3_-_80802789 22.188 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr4_+_48045144 18.696 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr14_-_60177482 17.978 ENSMUST00000140924.1
 Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr12_-_14152038 16.468 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chr4_-_20778527 15.367 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3
chr17_+_48932368 14.141 ENSMUST00000046254.2
 Lrfn2
leucine rich repeat and fibronectin type III domain containing 2
chr9_-_29963112 14.115 ENSMUST00000075069.4
 Ntm
neurotrimin
chr19_+_23758819 14.053 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr9_-_40346290 13.890 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr18_-_25753852 13.884 ENSMUST00000025117.6
ENSMUST00000115816.2
 Celf4

CUGBP, Elav-like family member 4

chr17_+_86167777 13.204 ENSMUST00000097275.2
 Prkce
protein kinase C, epsilon
chr12_-_67221221 12.929 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr2_-_113217051 11.909 ENSMUST00000080673.5
 Ryr3
ryanodine receptor 3
chr1_+_75507077 11.866 ENSMUST00000037330.4
 Inha
inhibin alpha
chr19_+_8664005 11.678 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr7_-_27446599 10.918 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4
chr8_-_48555846 10.801 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr3_+_105452326 10.695 ENSMUST00000098761.3
 Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr15_+_81936911 10.672 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 26.9 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
4.0 23.8 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 21.6 GO:0002028 regulation of sodium ion transport(GO:0002028)
6.2 18.7 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.4 17.1 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
0.8 16.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
2.7 16.0 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
1.8 14.3 GO:0097264 self proteolysis(GO:0097264)
0.9 14.1 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.9 13.3 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
3.3 13.2 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.1 12.7 GO:0010977 negative regulation of neuron projection development(GO:0010977)
2.0 11.8 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
2.3 11.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
1.8 10.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.2 10.8 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.4 10.8 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
1.1 10.7 GO:0071435 potassium ion export(GO:0071435)
3.4 10.2 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 10.2 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 38.1 GO:0005802 trans-Golgi network(GO:0005802)
1.7 33.9 GO:0032279 asymmetric synapse(GO:0032279)
0.2 26.4 GO:0043197 dendritic spine(GO:0043197)
0.0 20.5 GO:0070062 extracellular exosome(GO:0070062)
0.1 19.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 17.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 17.1 GO:0005887 integral component of plasma membrane(GO:0005887)
5.3 16.0 GO:0043512 inhibin A complex(GO:0043512)
0.1 12.5 GO:0000139 Golgi membrane(GO:0000139)
2.4 11.9 GO:0030314 junctional membrane complex(GO:0030314)
0.7 11.3 GO:0031143 pseudopodium(GO:0031143)
0.2 11.2 GO:0042734 presynaptic membrane(GO:0042734)
1.8 10.9 GO:0008091 spectrin(GO:0008091)
0.5 10.8 GO:0031430 M band(GO:0031430)
0.4 10.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
3.5 10.6 GO:0071953 elastic fiber(GO:0071953)
2.0 10.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.3 10.0 GO:0033268 node of Ranvier(GO:0033268)
0.3 9.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.0 9.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 28.4 GO:0030507 spectrin binding(GO:0030507)
1.3 26.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
4.0 23.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.4 20.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
1.0 16.5 GO:0001223 transcription coactivator binding(GO:0001223)
1.8 16.0 GO:0034711 inhibin binding(GO:0034711)
0.5 14.0 GO:0005272 sodium channel activity(GO:0005272)
3.3 13.2 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.3 13.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.3 12.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 12.0 GO:0043015 gamma-tubulin binding(GO:0043015)
4.0 11.9 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
2.0 11.8 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
3.8 11.3 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
2.1 10.7 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
1.7 10.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.4 9.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.5 9.2 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
1.1 9.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 9.0 GO:0050840 extracellular matrix binding(GO:0050840)