Motif ID: Esr1

Z-value: 1.165


Transcription factors associated with Esr1:

Gene SymbolEntrez IDGene Name
Esr1 ENSMUSG00000019768.10 Esr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr1mm10_v2_chr10_+_4710119_4710166-0.191.4e-01Click!


Activity profile for motif Esr1.

activity profile for motif Esr1


Sorted Z-values histogram for motif Esr1

Sorted Z-values for motif Esr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_102365111 10.098 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr10_-_77113676 9.811 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr18_+_74442551 9.453 ENSMUST00000121875.1
 Myo5b
myosin VB
chr18_+_74442500 9.356 ENSMUST00000074157.6
 Myo5b
myosin VB
chr2_-_166155272 9.296 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr11_-_115612491 7.679 ENSMUST00000106507.2
 Mif4gd
MIF4G domain containing
chr7_+_144915100 7.577 ENSMUST00000128057.1
 Oraov1
oral cancer overexpressed 1
chr2_+_109917639 7.575 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr4_+_124986430 7.545 ENSMUST00000030687.7
 Rspo1
R-spondin homolog (Xenopus laevis)
chr9_+_54764748 7.445 ENSMUST00000034830.8
 Crabp1
cellular retinoic acid binding protein I
chr7_-_30973399 7.288 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr7_-_30973367 7.121 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr9_-_63711969 7.041 ENSMUST00000154323.1
 Smad3
SMAD family member 3
chr7_-_30973464 6.813 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr8_+_84021444 6.765 ENSMUST00000055077.6
 Palm3
paralemmin 3
chr12_+_109747903 6.679 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr6_+_66535390 6.613 ENSMUST00000116605.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr2_+_122147680 6.519 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr6_-_125165707 6.010 ENSMUST00000118875.1
 Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr2_+_27886416 5.938 ENSMUST00000028280.7
 Col5a1
collagen, type V, alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 301 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.1 21.2 GO:1904274 tricellular tight junction assembly(GO:1904274)
4.7 18.8 GO:0032439 endosome localization(GO:0032439)
4.1 16.6 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.9 15.9 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
1.7 11.9 GO:1904667 negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.5 10.9 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 10.3 GO:0007088 regulation of mitotic nuclear division(GO:0007088)
0.3 10.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
1.0 9.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.8 9.6 GO:2000254 regulation of male germ cell proliferation(GO:2000254)
2.3 9.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.9 9.1 GO:0008063 Toll signaling pathway(GO:0008063)
1.7 8.6 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.5 8.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
2.6 7.8 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
2.5 7.6 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
2.5 7.4 GO:0016115 terpenoid catabolic process(GO:0016115)
2.4 7.3 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.1 7.2 GO:0051099 positive regulation of binding(GO:0051099)
0.3 7.1 GO:0009649 entrainment of circadian clock(GO:0009649)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 21.2 GO:0061689 tricellular tight junction(GO:0061689)
3.1 18.8 GO:0045179 apical cortex(GO:0045179)
2.6 18.5 GO:0097452 GAIT complex(GO:0097452)
1.3 18.1 GO:0035686 sperm fibrous sheath(GO:0035686)
1.3 16.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 16.7 GO:0005643 nuclear pore(GO:0005643)
0.2 16.4 GO:0005581 collagen trimer(GO:0005581)
0.0 14.4 GO:0005615 extracellular space(GO:0005615)
0.0 13.1 GO:0005730 nucleolus(GO:0005730)
0.1 11.0 GO:0014704 intercalated disc(GO:0014704)
0.0 9.9 GO:0000790 nuclear chromatin(GO:0000790)
0.1 9.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 8.8 GO:0005871 kinesin complex(GO:0005871)
0.2 8.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.2 7.3 GO:0030896 checkpoint clamp complex(GO:0030896)
1.4 7.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
1.3 6.3 GO:0033093 Weibel-Palade body(GO:0033093)
2.0 5.9 GO:0005588 collagen type V trimer(GO:0005588)
0.6 5.4 GO:0061574 ASAP complex(GO:0061574)
0.1 5.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 221 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 27.8 GO:0003774 motor activity(GO:0003774)
1.2 20.9 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.0 17.6 GO:0042803 protein homodimerization activity(GO:0042803)
5.5 16.6 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.1 12.8 GO:0003729 mRNA binding(GO:0003729)
0.7 10.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.7 10.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.6 10.1 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
1.7 9.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 9.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
1.9 9.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
2.2 8.6 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 8.1 GO:0000049 tRNA binding(GO:0000049)
2.6 7.8 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 7.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
2.6 7.7 GO:0004566 beta-glucuronidase activity(GO:0004566)
1.2 7.4 GO:0019841 retinol binding(GO:0019841)
1.1 7.4 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
1.4 7.0 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.8 7.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)