Motif ID: Esr2

Z-value: 1.910


Transcription factors associated with Esr2:

Gene SymbolEntrez IDGene Name
Esr2 ENSMUSG00000021055.7 Esr2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr2mm10_v2_chr12_-_76177251_76177265-0.274.0e-02Click!


Activity profile for motif Esr2.

activity profile for motif Esr2


Sorted Z-values histogram for motif Esr2

Sorted Z-values for motif Esr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_32276400 22.340 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_+_32276893 14.309 ENSMUST00000145569.1
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr7_-_103853199 12.451 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr11_+_78499087 11.348 ENSMUST00000017488.4
 Vtn
vitronectin
chrX_+_150547375 10.009 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chr13_+_98354234 9.037 ENSMUST00000105098.3
 Foxd1
forkhead box D1
chr11_-_75422524 8.657 ENSMUST00000125982.1
ENSMUST00000137103.1
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr11_-_75422586 7.820 ENSMUST00000138661.1
ENSMUST00000000769.7
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr11_+_32296489 7.703 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr11_+_32283511 7.566 ENSMUST00000093209.3
 Hba-a1
hemoglobin alpha, adult chain 1
chr6_+_4504814 7.479 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr12_+_109459843 6.761 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr6_+_4505493 6.466 ENSMUST00000031668.8
 Col1a2
collagen, type I, alpha 2
chr4_+_155839724 5.744 ENSMUST00000030947.3
 Mxra8
matrix-remodelling associated 8
chr12_+_109453455 5.488 ENSMUST00000109844.4
ENSMUST00000109842.2
ENSMUST00000109843.1
ENSMUST00000109846.4
ENSMUST00000173539.1
ENSMUST00000109841.2
 Dlk1





delta-like 1 homolog (Drosophila)





chr11_+_85832551 5.415 ENSMUST00000000095.6
 Tbx2
T-box 2
chr7_-_142578093 5.215 ENSMUST00000149974.1
ENSMUST00000152754.1
 H19

H19 fetal liver mRNA

chr8_+_70501116 5.144 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr13_+_38345716 5.103 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr4_-_136892867 4.739 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 916 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.8 49.1 GO:0015671 oxygen transport(GO:0015671)
0.6 22.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.5 19.1 GO:0048821 erythrocyte development(GO:0048821)
1.4 18.1 GO:0043589 skin morphogenesis(GO:0043589)
1.7 17.3 GO:0097421 liver regeneration(GO:0097421)
1.7 15.5 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.7 14.9 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.3 12.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
3.7 11.2 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
0.6 11.0 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
1.3 10.0 GO:0097460 ferrous iron import into cell(GO:0097460)
0.3 9.8 GO:0070206 protein trimerization(GO:0070206)
0.7 9.3 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.9 9.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
3.0 9.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.7 8.7 GO:0042637 catagen(GO:0042637)
0.5 8.0 GO:0050667 homocysteine metabolic process(GO:0050667)
2.6 7.9 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
1.1 7.8 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.7 7.8 GO:2000653 regulation of genetic imprinting(GO:2000653)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 320 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 195.9 GO:1903561 extracellular organelle(GO:0043230) extracellular vesicle(GO:1903561)
8.0 64.4 GO:0005833 hemoglobin complex(GO:0005833)
0.1 40.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 35.8 GO:0031012 extracellular matrix(GO:0031012)
0.4 27.0 GO:0005581 collagen trimer(GO:0005581)
0.0 20.4 GO:0005739 mitochondrion(GO:0005739)
5.7 17.0 GO:0005584 collagen type I trimer(GO:0005584)
1.1 15.6 GO:0043203 axon hillock(GO:0043203)
2.9 14.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
1.1 13.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.3 13.4 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 13.4 GO:0072562 blood microparticle(GO:0072562)
0.3 12.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 11.8 GO:0016459 myosin complex(GO:0016459)
0.1 11.7 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
1.4 11.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 10.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.5 10.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 9.8 GO:0005901 caveola(GO:0005901)
0.1 8.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 568 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.8 49.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.7 30.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.2 24.4 GO:0005044 scavenger receptor activity(GO:0005044)
1.5 22.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
3.8 15.3 GO:0031720 haptoglobin binding(GO:0031720)
1.0 14.5 GO:0046977 TAP binding(GO:0046977)
0.2 13.8 GO:0008201 heparin binding(GO:0008201)
0.1 13.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 11.8 GO:0016594 glycine binding(GO:0016594)
1.9 11.4 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 10.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 10.1 GO:0005509 calcium ion binding(GO:0005509)
0.3 9.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.7 9.5 GO:0008301 DNA binding, bending(GO:0008301)
0.3 8.6 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.2 8.6 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 8.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 8.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 8.4 GO:0003924 GTPase activity(GO:0003924)
1.2 8.3 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)