Motif ID: Esrrb_Esrra

Z-value: 1.016

Transcription factors associated with Esrrb_Esrra:

Gene SymbolEntrez IDGene Name
Esrra ENSMUSG00000024955.7 Esrra
Esrrb ENSMUSG00000021255.11 Esrrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrramm10_v2_chr19_-_6921804_69218340.302.2e-02Click!
Esrrbmm10_v2_chr12_+_86470109_86470122-0.085.5e-01Click!


Activity profile for motif Esrrb_Esrra.

activity profile for motif Esrrb_Esrra


Sorted Z-values histogram for motif Esrrb_Esrra

Sorted Z-values for motif Esrrb_Esrra



Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrb_Esrra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_141874870 11.923 ENSMUST00000182079.1
 Gm15294
predicted gene 15294
chr11_-_55033398 5.950 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6

chr7_-_141429351 5.886 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
 Cend1


cell cycle exit and neuronal differentiation 1


chr1_+_181352618 5.370 ENSMUST00000161880.1
ENSMUST00000027795.7
 Cnih3

cornichon homolog 3 (Drosophila)

chr1_-_167393826 5.313 ENSMUST00000028005.2
 Mgst3
microsomal glutathione S-transferase 3
chr6_+_90550789 5.234 ENSMUST00000130418.1
ENSMUST00000032175.8
 Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr9_+_44043384 4.984 ENSMUST00000114840.1
 Thy1
thymus cell antigen 1, theta
chr5_+_118027743 4.974 ENSMUST00000031304.7
 Tesc
tescalcin
chr7_-_141429433 4.552 ENSMUST00000124444.1
 Cend1
cell cycle exit and neuronal differentiation 1
chr8_-_13494479 4.216 ENSMUST00000033828.5
 Gas6
growth arrest specific 6
chr10_+_79716588 4.184 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr2_+_172345565 4.174 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr18_+_45268876 4.157 ENSMUST00000183850.1
ENSMUST00000066890.7
 Kcnn2

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

chr1_-_51941261 4.073 ENSMUST00000097103.3
 Gm8420
predicted gene 8420
chr2_+_121357714 4.029 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr12_-_34291092 3.766 ENSMUST00000166546.2
 Gm18025
predicted gene, 18025
chr15_+_3270767 3.723 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr2_+_178119166 3.649 ENSMUST00000108916.1
 Phactr3
phosphatase and actin regulator 3
chr6_+_38663061 3.478 ENSMUST00000114874.3
 Clec2l
C-type lectin domain family 2, member L
chr11_+_7063423 3.468 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 235 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 10.4 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.0 9.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.3 7.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 6.6 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 6.6 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179)
0.1 6.5 GO:0032091 negative regulation of protein binding(GO:0032091)
0.1 6.5 GO:0006342 chromatin silencing(GO:0006342)
0.3 5.8 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.2 5.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.7 5.2 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
1.2 5.0 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417)
0.8 5.0 GO:0046549 retinal cone cell development(GO:0046549)
0.1 4.9 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.2 4.8 GO:0001893 maternal placenta development(GO:0001893)
1.4 4.2 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of protein import into nucleus, translocation(GO:0033159) hematopoietic stem cell migration(GO:0035701) regulation of dendritic cell chemotaxis(GO:2000508) positive regulation of dendritic cell chemotaxis(GO:2000510)
1.0 4.2 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.7 4.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 4.0 GO:0000266 mitochondrial fission(GO:0000266)
0.1 4.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.5 3.7 GO:0001887 selenium compound metabolic process(GO:0001887)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 15.8 GO:0070469 respiratory chain(GO:0070469)
0.5 11.4 GO:0045259 proton-transporting ATP synthase complex(GO:0045259)
0.0 8.3 GO:0030027 lamellipodium(GO:0030027)
0.6 6.7 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 6.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 5.9 GO:0031902 late endosome membrane(GO:0031902)
0.2 5.5 GO:0032590 dendrite membrane(GO:0032590)
0.1 5.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 4.8 GO:0005844 polysome(GO:0005844)
0.4 4.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.5 4.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 3.8 GO:0000786 nucleosome(GO:0000786)
0.5 3.6 GO:0001520 outer dense fiber(GO:0001520)
0.1 3.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.3 3.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.4 2.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 2.6 GO:0031901 early endosome membrane(GO:0031901)
0.2 2.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 2.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.0 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.4 9.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 8.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 8.4 GO:0016247 channel regulator activity(GO:0016247)
1.9 7.7 GO:0004111 creatine kinase activity(GO:0004111)
0.5 7.6 GO:0008430 selenium binding(GO:0008430)
0.2 6.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 6.2 GO:0035613 RNA stem-loop binding(GO:0035613)
0.3 5.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
1.7 5.2 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.4 5.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.0 5.0 GO:0034235 GPI anchor binding(GO:0034235)
0.5 4.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.0 4.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.8 4.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.4 4.2 GO:0030296 protein tyrosine kinase activator activity(GO:0030296) receptor agonist activity(GO:0048018)
0.0 4.1 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA methyltransferase activity(GO:0008649) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) rRNA (uridine) methyltransferase activity(GO:0016436) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.1 3.7 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.6 3.5 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 3.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)