Motif ID: Etv6

Z-value: 1.173


Transcription factors associated with Etv6:

Gene SymbolEntrez IDGene Name
Etv6 ENSMUSG00000030199.10 Etv6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv6mm10_v2_chr6_+_134035691_1340357170.114.3e-01Click!


Activity profile for motif Etv6.

activity profile for motif Etv6


Sorted Z-values histogram for motif Etv6

Sorted Z-values for motif Etv6



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_109459843 5.743 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chrX_-_141725181 4.335 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr4_+_118409331 4.067 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
 Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)





chr8_+_105297663 3.611 ENSMUST00000015003.8
 E2f4
E2F transcription factor 4
chr5_-_149636164 3.367 ENSMUST00000076410.4
 Hsph1
heat shock 105kDa/110kDa protein 1
chr9_-_21149894 3.229 ENSMUST00000019615.9
 Cdc37
cell division cycle 37
chr11_+_120948480 3.024 ENSMUST00000070653.6
 Slc16a3
solute carrier family 16 (monocarboxylic acid transporters), member 3
chr7_+_127233227 2.904 ENSMUST00000056232.6
 Zfp553
zinc finger protein 553
chr2_+_180257373 2.865 ENSMUST00000059080.6
 Rps21
ribosomal protein S21
chr15_+_12824815 2.750 ENSMUST00000169061.1
 Drosha
drosha, ribonuclease type III
chr11_-_35834492 2.624 ENSMUST00000018992.3
 Rars
arginyl-tRNA synthetase
chr10_-_67285180 2.591 ENSMUST00000159002.1
ENSMUST00000077839.6
 Nrbf2

nuclear receptor binding factor 2

chr9_-_78489141 2.534 ENSMUST00000154207.1
 Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr7_-_46919915 2.490 ENSMUST00000143413.1
ENSMUST00000014546.8
 Tsg101

tumor susceptibility gene 101

chr15_+_12824841 2.404 ENSMUST00000090292.5
 Drosha
drosha, ribonuclease type III
chr3_-_95871367 2.331 ENSMUST00000142437.1
ENSMUST00000067298.4
 Mrps21

mitochondrial ribosomal protein S21

chr3_-_94886945 2.297 ENSMUST00000005923.6
 Psmb4
proteasome (prosome, macropain) subunit, beta type 4
chr7_+_127233044 2.259 ENSMUST00000106312.3
 Zfp553
zinc finger protein 553
chr18_+_62548911 2.257 ENSMUST00000055725.4
ENSMUST00000162365.1
 Spink10

serine peptidase inhibitor, Kazal type 10

chr18_+_31789120 2.226 ENSMUST00000025106.3
 Polr2d
polymerase (RNA) II (DNA directed) polypeptide D

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.5 GO:0006412 translation(GO:0006412)
0.1 8.5 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 7.4 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 6.2 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.2 5.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.3 5.4 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.6 5.2 GO:0031053 production of siRNA involved in RNA interference(GO:0030422) primary miRNA processing(GO:0031053)
0.4 5.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.6 5.0 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 4.5 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.3 4.4 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 4.4 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 4.3 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.2 4.0 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 3.8 GO:0045116 protein neddylation(GO:0045116)
0.0 3.8 GO:0006413 translational initiation(GO:0006413)
0.6 3.7 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.1 3.7 GO:0032543 mitochondrial translation(GO:0032543)
0.3 3.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 3.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 9.2 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.2 7.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 5.7 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.1 5.3 GO:0032587 ruffle membrane(GO:0032587)
1.7 5.2 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.7 5.0 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 5.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.7 4.7 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.5 4.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 4.4 GO:0016592 mediator complex(GO:0016592)
0.5 4.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 4.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 3.8 GO:0005667 transcription factor complex(GO:0005667)
0.1 3.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 3.3 GO:0000243 commitment complex(GO:0000243)
0.2 3.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.2 3.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 3.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 2.9 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 14.3 GO:0044822 poly(A) RNA binding(GO:0044822)
0.5 7.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.7 6.1 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 5.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 5.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 5.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 5.0 GO:0070628 proteasome binding(GO:0070628)
0.7 4.6 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 4.4 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 4.4 GO:0019887 protein kinase regulator activity(GO:0019887)
0.1 4.3 GO:0005158 insulin receptor binding(GO:0005158)
0.1 4.3 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA methyltransferase activity(GO:0008649) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) rRNA (uridine) methyltransferase activity(GO:0016436) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.0 4.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 3.8 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 3.8 GO:0017124 SH3 domain binding(GO:0017124)
0.1 3.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 3.4 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 3.3 GO:0043130 ubiquitin binding(GO:0043130)
0.2 3.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)