Motif ID: Evx2

Z-value: 0.698


Transcription factors associated with Evx2:

Gene SymbolEntrez IDGene Name
Evx2 ENSMUSG00000001815.9 Evx2



Activity profile for motif Evx2.

activity profile for motif Evx2


Sorted Z-values histogram for motif Evx2

Sorted Z-values for motif Evx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Evx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_168767136 12.335 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr2_-_168767029 8.928 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chrX_-_60893430 5.371 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr2_-_155074447 4.112 ENSMUST00000137242.1
ENSMUST00000054607.9
Ahcy

S-adenosylhomocysteine hydrolase

chr17_+_17402672 3.962 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr18_-_88927447 3.723 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6
chrX_+_58030999 3.692 ENSMUST00000088631.4
ENSMUST00000088629.3
Zic3

zinc finger protein of the cerebellum 3

chr7_-_126800354 3.564 ENSMUST00000106348.1
Aldoa
aldolase A, fructose-bisphosphate
chr7_-_143460989 3.502 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr4_-_132345686 3.472 ENSMUST00000030726.6
Rcc1
regulator of chromosome condensation 1
chr4_-_132345715 3.411 ENSMUST00000084250.4
Rcc1
regulator of chromosome condensation 1
chr4_-_132075250 3.125 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1

erythrocyte protein band 4.1

chr13_+_51645232 3.074 ENSMUST00000075853.5
Cks2
CDC28 protein kinase regulatory subunit 2
chrX_+_58030622 2.774 ENSMUST00000088627.4
Zic3
zinc finger protein of the cerebellum 3
chr4_-_129227883 2.704 ENSMUST00000106051.1
C77080
expressed sequence C77080
chr14_+_62292475 2.523 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chr6_-_124779686 2.501 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr9_+_47530173 2.318 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
Cadm1





cell adhesion molecule 1





chr19_+_47067721 2.155 ENSMUST00000026027.5
Taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr5_-_98030727 2.125 ENSMUST00000031281.9
Antxr2
anthrax toxin receptor 2
chr4_+_109978004 2.013 ENSMUST00000061187.3
Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr17_-_47834682 1.843 ENSMUST00000066368.6
Mdfi
MyoD family inhibitor
chr9_-_66514567 1.820 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chr4_+_140701466 1.811 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr11_+_60537978 1.636 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr7_+_51879041 1.627 ENSMUST00000107591.2
Gas2
growth arrest specific 2
chr14_+_48446128 1.243 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chr2_+_91256813 1.192 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
Pacsin3



protein kinase C and casein kinase substrate in neurons 3



chr3_-_130709419 1.141 ENSMUST00000043937.7
Ostc
oligosaccharyltransferase complex subunit
chr2_+_91257323 1.085 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chrX_-_111536325 1.034 ENSMUST00000156639.1
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr6_-_69400097 1.027 ENSMUST00000177795.1
Igkv4-62
immunoglobulin kappa variable 4-62
chr13_+_38204928 0.979 ENSMUST00000091641.5
ENSMUST00000178564.1
Snrnp48

small nuclear ribonucleoprotein 48 (U11/U12)

chr8_-_31168699 0.871 ENSMUST00000033983.4
Mak16
MAK16 homolog (S. cerevisiae)
chr14_+_73173825 0.861 ENSMUST00000166875.1
Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr15_+_34453285 0.830 ENSMUST00000060894.7
BC030476
cDNA sequence BC030476
chr6_-_69284319 0.825 ENSMUST00000103349.1
Igkv4-69
immunoglobulin kappa variable 4-69
chr11_+_35121126 0.793 ENSMUST00000069837.3
Slit3
slit homolog 3 (Drosophila)
chr10_-_128525859 0.768 ENSMUST00000026427.6
Esyt1
extended synaptotagmin-like protein 1
chr4_-_42661893 0.764 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr3_+_121291725 0.705 ENSMUST00000039442.7
Alg14
asparagine-linked glycosylation 14
chr17_+_36837123 0.696 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
Trim26





tripartite motif-containing 26





chr14_-_59365410 0.653 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d

PHD finger protein 11D

chr2_-_84715160 0.615 ENSMUST00000035840.5
Zdhhc5
zinc finger, DHHC domain containing 5
chr18_+_9958147 0.605 ENSMUST00000025137.7
Thoc1
THO complex 1
chr6_+_116650674 0.598 ENSMUST00000067354.5
ENSMUST00000178241.1
8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr10_-_8886033 0.532 ENSMUST00000015449.5
Sash1
SAM and SH3 domain containing 1
chr18_+_24603952 0.518 ENSMUST00000025120.6
Elp2
elongator acetyltransferase complex subunit 2
chr2_+_119047116 0.489 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5

cancer susceptibility candidate 5

chr2_-_27475622 0.479 ENSMUST00000138693.1
ENSMUST00000113941.2
ENSMUST00000077737.6
Brd3


bromodomain containing 3


chr8_+_92855319 0.422 ENSMUST00000046290.1
Lpcat2
lysophosphatidylcholine acyltransferase 2
chr15_-_58034289 0.413 ENSMUST00000100655.3
9130401M01Rik
RIKEN cDNA 9130401M01 gene
chr10_-_80701811 0.369 ENSMUST00000003438.9
Mob3a
MOB kinase activator 3A
chr3_+_94837702 0.327 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
Pogz


pogo transposable element with ZNF domain


chr19_-_41933276 0.318 ENSMUST00000075280.4
ENSMUST00000112123.2
Exosc1

exosome component 1

chr2_-_132247747 0.259 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
Tmem230


transmembrane protein 230


chr10_+_70175011 0.245 ENSMUST00000156001.1
ENSMUST00000135607.1
Ccdc6

coiled-coil domain containing 6

chr12_+_109545390 0.156 ENSMUST00000146701.1
Meg3
maternally expressed 3
chr4_+_100478806 0.154 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr7_+_27927592 0.144 ENSMUST00000181644.1
Gm26891
predicted gene, 26891
chrM_+_7759 0.112 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr2_-_150255591 0.101 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr8_-_35495487 0.056 ENSMUST00000033927.6
Eri1
exoribonuclease 1
chr2_+_119047129 0.048 ENSMUST00000153300.1
ENSMUST00000028799.5
Casc5

cancer susceptibility candidate 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 21.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.1 6.5 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.8 2.3 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.6 1.8 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.5 4.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.4 1.6 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.4 3.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 5.4 GO:0007530 sex determination(GO:0007530)
0.2 0.6 GO:0048296 isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296)
0.2 0.5 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.2 4.0 GO:0097352 autophagosome maturation(GO:0097352)
0.2 3.5 GO:0060065 uterus development(GO:0060065)
0.1 2.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.8 GO:0070100 negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.1 2.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 0.4 GO:0046469 platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.1 2.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 1.8 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 1.0 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.1 6.9 GO:0007052 mitotic spindle organization(GO:0007052)
0.1 3.7 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.5 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 2.1 GO:1901998 toxin transport(GO:1901998)
0.0 0.7 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 2.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.9 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 1.9 GO:0007127 meiosis I(GO:0007127)
0.0 0.2 GO:0051382 kinetochore assembly(GO:0051382)
0.0 1.6 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.2 GO:0008340 determination of adult lifespan(GO:0008340)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 25.0 GO:0000792 heterochromatin(GO:0000792)
0.2 2.3 GO:0070852 cell body fiber(GO:0070852)
0.2 1.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 2.2 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 6.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 1.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 3.7 GO:0001772 immunological synapse(GO:0001772)
0.1 0.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.6 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.8 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 1.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 1.6 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.6 3.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.6 4.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.4 1.6 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.3 2.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 3.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 5.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 2.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.4 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 0.8 GO:0048495 Roundabout binding(GO:0048495)
0.1 3.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 3.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 31.1 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.0 1.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.0 0.5 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 2.3 GO:0030165 PDZ domain binding(GO:0030165)