Motif ID: Ezh2_Atf2_Ikzf1

Z-value: 2.135

Transcription factors associated with Ezh2_Atf2_Ikzf1:

Gene SymbolEntrez IDGene Name
Atf2 ENSMUSG00000027104.12 Atf2
Ezh2 ENSMUSG00000029687.10 Ezh2
Ikzf1 ENSMUSG00000018654.11 Ikzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf2mm10_v2_chr2_-_73892588_738926160.783.4e-13Click!
Ezh2mm10_v2_chr6_-_47594967_47595047-0.321.4e-02Click!


Activity profile for motif Ezh2_Atf2_Ikzf1.

activity profile for motif Ezh2_Atf2_Ikzf1


Sorted Z-values histogram for motif Ezh2_Atf2_Ikzf1

Sorted Z-values for motif Ezh2_Atf2_Ikzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ezh2_Atf2_Ikzf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_152081529 44.612 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr4_-_82505749 32.746 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505707 29.637 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr16_-_23520579 23.430 ENSMUST00000089883.5
 Masp1
mannan-binding lectin serine peptidase 1
chr14_-_79771305 22.234 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr9_-_117252450 21.649 ENSMUST00000111773.3
ENSMUST00000068962.7
ENSMUST00000044901.7
 Rbms3


RNA binding motif, single stranded interacting protein


chr1_-_154725920 20.834 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr9_+_27790947 20.698 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr6_+_141524379 20.438 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr19_+_26623419 19.276 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr13_+_54371340 18.827 ENSMUST00000026985.8
 Cplx2
complexin 2
chr12_-_78980758 18.647 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr5_+_98180866 18.291 ENSMUST00000112959.1
 Prdm8
PR domain containing 8
chr7_-_79386943 17.956 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr4_+_101550411 17.812 ENSMUST00000094953.4
ENSMUST00000106933.1
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr13_+_42709482 17.706 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr2_+_4300462 17.565 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr17_-_90455872 16.076 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr15_-_76521902 16.018 ENSMUST00000164703.1
ENSMUST00000096365.3
 Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chrX_-_73869804 15.948 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 393 entries
Log-likelihood per target Total log-likelihoodTermDescription
16.3 65.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.8 55.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.5 55.4 GO:2001222 regulation of neuron migration(GO:2001222)
0.6 52.6 GO:0001578 microtubule bundle formation(GO:0001578)
1.7 41.3 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.5 33.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.9 33.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.1 33.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.8 32.8 GO:0006376 mRNA splice site selection(GO:0006376)
2.1 29.4 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.4 25.4 GO:0007612 learning(GO:0007612)
5.0 24.8 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
2.6 23.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
3.3 23.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
1.6 22.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.8 21.8 GO:2000463 positive regulation of excitatory postsynaptic potential(GO:2000463)
0.2 20.9 GO:0071805 potassium ion transmembrane transport(GO:0071805)
2.5 20.1 GO:0097369 sodium ion import(GO:0097369)
2.0 19.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.5 19.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 88.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 84.7 GO:0016021 integral component of membrane(GO:0016021)
3.4 70.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 52.4 GO:0045211 postsynaptic membrane(GO:0045211)
5.2 46.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
1.0 42.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
2.0 39.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.3 36.7 GO:0000118 histone deacetylase complex(GO:0000118)
2.0 34.7 GO:0032279 asymmetric synapse(GO:0032279)
0.5 30.0 GO:0030315 T-tubule(GO:0030315)
0.2 24.2 GO:0030027 lamellipodium(GO:0030027)
1.5 23.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 21.6 GO:0043209 myelin sheath(GO:0043209)
0.2 21.2 GO:0043204 perikaryon(GO:0043204)
1.5 19.8 GO:0042788 polysomal ribosome(GO:0042788)
0.2 19.1 GO:0035097 histone methyltransferase complex(GO:0035097)
4.7 18.8 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.7 18.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 16.6 GO:0031225 anchored component of membrane(GO:0031225)
1.8 16.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 276 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 49.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
5.7 45.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 45.3 GO:0015631 tubulin binding(GO:0015631)
0.5 36.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
2.0 34.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.4 34.5 GO:0017075 syntaxin-1 binding(GO:0017075)
4.8 33.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
2.5 29.9 GO:0097109 neuroligin family protein binding(GO:0097109)
2.0 27.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 23.8 GO:0005509 calcium ion binding(GO:0005509)
0.3 23.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 22.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
5.1 20.4 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.7 19.0 GO:0001968 fibronectin binding(GO:0001968)
2.3 18.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.2 18.2 GO:0030674 protein binding, bridging(GO:0030674)
3.0 18.1 GO:0032051 clathrin light chain binding(GO:0032051)
3.0 18.0 GO:0019841 retinol binding(GO:0019841)
0.8 17.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 17.3 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738) protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)