Motif ID: Fli1

Z-value: 1.254


Transcription factors associated with Fli1:

Gene SymbolEntrez IDGene Name
Fli1 ENSMUSG00000016087.7 Fli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fli1mm10_v2_chr9_-_32541589_32541602-0.273.7e-02Click!


Activity profile for motif Fli1.

activity profile for motif Fli1


Sorted Z-values histogram for motif Fli1

Sorted Z-values for motif Fli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Fli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 137 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_32000452 31.852 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr11_+_32000496 26.155 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chrX_-_136868537 22.390 ENSMUST00000058814.6
 Rab9b
RAB9B, member RAS oncogene family
chr4_+_43406435 18.960 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr1_-_175491130 18.370 ENSMUST00000027812.5
 Rgs7
regulator of G protein signaling 7
chr7_-_140082489 17.181 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr1_-_191318090 16.121 ENSMUST00000046770.9
 Nenf
neuron derived neurotrophic factor
chr1_-_126492900 13.390 ENSMUST00000161954.1
 Nckap5
NCK-associated protein 5
chr2_+_65845767 10.346 ENSMUST00000122912.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr2_+_65845833 9.454 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr12_+_86678685 9.097 ENSMUST00000021681.3
 Vash1
vasohibin 1
chr5_+_117133567 9.090 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
 Taok3


TAO kinase 3


chr16_-_42340595 9.075 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr13_-_51203065 8.997 ENSMUST00000091708.4
 Hist1h2al
histone cluster 1, H2al
chr6_-_77979652 8.930 ENSMUST00000161846.1
ENSMUST00000160894.1
 Ctnna2

catenin (cadherin associated protein), alpha 2

chr6_-_77979515 8.725 ENSMUST00000159626.1
ENSMUST00000075340.5
ENSMUST00000162273.1
 Ctnna2


catenin (cadherin associated protein), alpha 2


chr15_-_76521902 8.136 ENSMUST00000164703.1
ENSMUST00000096365.3
 Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr11_+_57011945 7.463 ENSMUST00000094179.4
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr11_+_57011798 7.353 ENSMUST00000036315.9
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr13_+_55464237 6.770 ENSMUST00000046533.7
 Prr7
proline rich 7 (synaptic)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 73.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 22.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
2.0 21.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.3 19.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 18.4 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
1.5 17.7 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
1.5 16.1 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.8 14.8 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.3 11.0 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
2.3 9.1 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
1.0 9.1 GO:0016198 axon choice point recognition(GO:0016198)
0.5 9.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
1.5 8.9 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
2.9 8.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 8.1 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 6.1 GO:0007631 feeding behavior(GO:0007631)
0.2 5.8 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 4.7 GO:0006821 chloride transport(GO:0006821)
0.2 4.6 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.3 4.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 86.8 GO:0031410 cytoplasmic vesicle(GO:0031410)
1.6 32.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.4 22.4 GO:0045335 phagocytic vesicle(GO:0045335)
1.3 18.4 GO:0044292 dendrite terminus(GO:0044292)
0.2 16.2 GO:0005913 cell-cell adherens junction(GO:0005913)
2.5 14.8 GO:0044308 axonal spine(GO:0044308)
0.5 9.1 GO:0031527 filopodium membrane(GO:0031527)
0.0 6.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 6.1 GO:0031225 anchored component of membrane(GO:0031225)
0.3 5.8 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 4.7 GO:0045202 synapse(GO:0045202)
0.1 4.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 4.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 4.1 GO:0005923 bicellular tight junction(GO:0005923)
0.0 3.2 GO:0043204 perikaryon(GO:0043204)
0.7 2.1 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
0.1 2.0 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 1.4 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 1.2 GO:0044300 cerebellar mossy fiber(GO:0044300)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
12.5 75.2 GO:0032051 clathrin light chain binding(GO:0032051)
1.1 32.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.4 22.1 GO:0019003 GDP binding(GO:0019003)
0.1 21.0 GO:0017137 Rab GTPase binding(GO:0017137)
1.1 18.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.4 16.2 GO:0045296 cadherin binding(GO:0045296)
2.1 14.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.5 9.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.3 8.9 GO:0070412 R-SMAD binding(GO:0070412)
0.1 7.3 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 7.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.5 5.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.5 5.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 4.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 4.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 4.1 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 4.1 GO:0030674 protein binding, bridging(GO:0030674)
0.1 3.8 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.9 3.6 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 3.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)