Motif ID: Fosb

Z-value: 0.439


Transcription factors associated with Fosb:

Gene SymbolEntrez IDGene Name
Fosb ENSMUSG00000003545.2 Fosb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosbmm10_v2_chr7_-_19310035_19310050-0.444.9e-04Click!


Activity profile for motif Fosb.

activity profile for motif Fosb


Sorted Z-values histogram for motif Fosb

Sorted Z-values for motif Fosb



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_118663235 3.088 ENSMUST00000099557.3
 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr14_+_27622433 2.489 ENSMUST00000090302.5
 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr4_+_42158092 2.157 ENSMUST00000098122.2
 Gm13306
predicted gene 13306
chr6_-_124769548 2.155 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr3_+_55461758 2.152 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr10_+_26078255 1.861 ENSMUST00000041011.3
 Gm9767
predicted gene 9767
chr1_-_12991109 1.848 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr14_+_80000292 1.827 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr8_-_8639363 1.780 ENSMUST00000152698.1
 Efnb2
ephrin B2
chr11_-_100397740 1.764 ENSMUST00000001592.8
ENSMUST00000107403.1
 Jup

junction plakoglobin

chr1_+_134560157 1.723 ENSMUST00000047714.7
 Kdm5b
lysine (K)-specific demethylase 5B
chr9_+_104566677 1.712 ENSMUST00000157006.1
 Cpne4
copine IV
chr11_-_84067063 1.697 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr1_+_134560190 1.689 ENSMUST00000112198.1
ENSMUST00000112197.1
 Kdm5b

lysine (K)-specific demethylase 5B

chr2_+_167777467 1.432 ENSMUST00000139927.1
ENSMUST00000127441.1
 Gm14321

predicted gene 14321

chr16_-_4880284 1.285 ENSMUST00000037843.6
 Ubald1
UBA-like domain containing 1
chr15_+_102503722 1.275 ENSMUST00000096145.4
 Gm10337
predicted gene 10337
chr2_+_156475844 1.212 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr7_-_4778141 1.146 ENSMUST00000094892.5
 Il11
interleukin 11
chr4_-_140774196 1.134 ENSMUST00000026381.6
 Padi4
peptidyl arginine deiminase, type IV
chr9_-_109059216 1.128 ENSMUST00000112053.1
 Trex1
three prime repair exonuclease 1
chr16_+_78930940 1.035 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin


chr2_-_151632471 0.995 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr2_+_156475803 0.953 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr6_+_17463927 0.935 ENSMUST00000115442.1
 Met
met proto-oncogene
chr11_-_120630516 0.908 ENSMUST00000106181.1
 Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr2_-_18048784 0.882 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr5_-_86676346 0.876 ENSMUST00000038448.6
 Tmprss11bnl
transmembrane protease, serine 11b N terminal like
chr2_-_29253001 0.875 ENSMUST00000071201.4
 Ntng2
netrin G2
chr13_-_113663670 0.865 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr19_+_5447692 0.859 ENSMUST00000025850.5
 Fosl1
fos-like antigen 1
chr1_-_51915968 0.834 ENSMUST00000046390.7
 Myo1b
myosin IB
chr11_-_69666062 0.826 ENSMUST00000108654.2
ENSMUST00000018918.5
 Cd68

CD68 antigen

chr6_+_86849488 0.818 ENSMUST00000089519.6
ENSMUST00000113668.1
 Aak1

AP2 associated kinase 1

chr11_+_80428598 0.786 ENSMUST00000173938.1
ENSMUST00000017572.7
 Psmd11

proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

chr9_-_109059711 0.767 ENSMUST00000061973.4
 Trex1
three prime repair exonuclease 1
chr6_-_113934679 0.761 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr3_+_123267445 0.682 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr15_-_76014318 0.650 ENSMUST00000060807.5
 Fam83h
family with sequence similarity 83, member H
chr12_-_85288419 0.634 ENSMUST00000121930.1
 Acyp1
acylphosphatase 1, erythrocyte (common) type
chr11_+_77801325 0.574 ENSMUST00000151373.2
ENSMUST00000172303.2
ENSMUST00000130305.2
ENSMUST00000164334.1
ENSMUST00000092884.4
 Myo18a




myosin XVIIIA




chr2_-_45110241 0.545 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr11_+_77801291 0.537 ENSMUST00000100794.3
 Myo18a
myosin XVIIIA
chr8_+_36489191 0.519 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chrX_-_75578188 0.502 ENSMUST00000033545.5
 Rab39b
RAB39B, member RAS oncogene family
chr5_-_21785115 0.499 ENSMUST00000115193.1
ENSMUST00000115192.1
ENSMUST00000115195.1
ENSMUST00000030771.5
 Dnajc2



DnaJ (Hsp40) homolog, subfamily C, member 2



chr11_-_50210765 0.468 ENSMUST00000143379.1
ENSMUST00000015981.5
ENSMUST00000102774.4
 Sqstm1


sequestosome 1


chr3_+_109573907 0.459 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr2_+_143915273 0.450 ENSMUST00000103172.3
 Dstn
destrin
chr8_+_4226827 0.439 ENSMUST00000053035.6
 Lrrc8e
leucine rich repeat containing 8 family, member E
chr8_+_107293500 0.434 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
 Nfat5


nuclear factor of activated T cells 5


chr7_+_126776939 0.417 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
 Ypel3






yippee-like 3 (Drosophila)






chr12_+_71015966 0.413 ENSMUST00000046305.5
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr10_-_86011833 0.412 ENSMUST00000105304.1
ENSMUST00000061699.5
 Bpifc

BPI fold containing family C

chr12_-_84194007 0.408 ENSMUST00000110294.1
 Elmsan1
ELM2 and Myb/SANT-like domain containing 1
chr6_+_42349826 0.406 ENSMUST00000070635.6
 Zyx
zyxin
chr9_+_122888471 0.387 ENSMUST00000063980.6
 Zkscan7
zinc finger with KRAB and SCAN domains 7
chr14_+_79426454 0.368 ENSMUST00000061222.7
 Kbtbd7
kelch repeat and BTB (POZ) domain containing 7
chr6_-_129533267 0.367 ENSMUST00000181594.1
 1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr17_-_45592485 0.365 ENSMUST00000166119.1
 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr18_+_61639542 0.329 ENSMUST00000183083.1
ENSMUST00000183087.1
 Gm20748

predicted gene, 20748

chr6_+_42350000 0.329 ENSMUST00000164375.1
 Zyx
zyxin
chr7_-_127946725 0.322 ENSMUST00000118755.1
ENSMUST00000094026.3
 Prss36

protease, serine, 36

chr3_-_88503187 0.315 ENSMUST00000120377.1
 Lmna
lamin A
chr15_-_102257449 0.274 ENSMUST00000043172.8
 Rarg
retinoic acid receptor, gamma
chr10_+_116143881 0.274 ENSMUST00000105271.2
 Ptprr
protein tyrosine phosphatase, receptor type, R
chr17_-_35697971 0.267 ENSMUST00000146472.1
 Ddr1
discoidin domain receptor family, member 1
chr3_-_88503331 0.264 ENSMUST00000029699.6
 Lmna
lamin A
chr17_+_46161021 0.261 ENSMUST00000024748.7
ENSMUST00000172170.1
 Gtpbp2

GTP binding protein 2

chr15_-_102257306 0.241 ENSMUST00000135466.1
 Rarg
retinoic acid receptor, gamma
chr1_+_86064619 0.209 ENSMUST00000027432.8
 Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr7_-_29505447 0.188 ENSMUST00000183096.1
ENSMUST00000085809.4
 Sipa1l3

signal-induced proliferation-associated 1 like 3

chrX_+_73675500 0.187 ENSMUST00000171398.1
 Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr14_-_55758458 0.181 ENSMUST00000001497.7
 Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr11_-_96075581 0.177 ENSMUST00000107686.1
ENSMUST00000107684.1
 Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr1_-_171240055 0.165 ENSMUST00000131286.1
 Ndufs2
NADH dehydrogenase (ubiquinone) Fe-S protein 2
chr13_-_54611274 0.164 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr11_-_96075655 0.163 ENSMUST00000090541.5
 Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr13_-_54611332 0.135 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr11_-_43747963 0.116 ENSMUST00000048578.2
ENSMUST00000109278.1
 Ttc1

tetratricopeptide repeat domain 1

chr7_-_45920830 0.100 ENSMUST00000164119.1
 Emp3
epithelial membrane protein 3
chr5_-_5265224 0.096 ENSMUST00000115450.1
 Cdk14
cyclin-dependent kinase 14
chr7_-_133782721 0.087 ENSMUST00000063669.1
 Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr17_-_45592262 0.080 ENSMUST00000164769.1
 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr11_-_102365111 0.054 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr12_+_83632208 0.030 ENSMUST00000048155.9
ENSMUST00000182618.1
ENSMUST00000183154.1
ENSMUST00000182036.1
ENSMUST00000182347.1
 Rbm25




RNA binding motif protein 25




chr18_+_40258361 0.025 ENSMUST00000091927.4
 Kctd16
potassium channel tetramerisation domain containing 16
chr3_-_88177671 0.002 ENSMUST00000181837.1
 1700113A16Rik
RIKEN cDNA 1700113A16 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0002159 desmosome assembly(GO:0002159)
0.4 3.4 GO:0034720 positive regulation of mammary gland epithelial cell proliferation(GO:0033601) histone H3-K4 demethylation(GO:0034720) mammary duct terminal end bud growth(GO:0060763)
0.2 1.8 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.2 1.1 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
0.1 0.6 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.1 1.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.5 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.8 GO:0048840 otolith development(GO:0048840)
0.1 1.1 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.1 0.9 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.4 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 0.9 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.4 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.3 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.4 GO:0015862 uridine transport(GO:0015862)
0.1 1.9 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 0.5 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 1.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 2.2 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.8 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.4 GO:0051014 actin filament severing(GO:0051014)
0.0 1.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.8 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.4 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 2.2 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 3.1 GO:0007613 memory(GO:0007613)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.5 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.6 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 1.0 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.0 1.1 GO:0046888 negative regulation of hormone secretion(GO:0046888)
0.0 0.5 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.0 1.0 GO:0030641 regulation of cellular pH(GO:0030641)
0.0 0.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 1.8 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.2 0.5 GO:0044754 amphisome(GO:0044753) autolysosome(GO:0044754)
0.1 1.8 GO:0042581 specific granule(GO:0042581)
0.1 0.6 GO:0005638 lamin filament(GO:0005638)
0.1 0.8 GO:0071439 clathrin complex(GO:0071439)
0.1 2.5 GO:0048786 presynaptic active zone(GO:0048786)
0.1 0.6 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 1.0 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 1.9 GO:0016459 myosin complex(GO:0016459)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 1.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.7 GO:0005913 cell-cell adherens junction(GO:0005913)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.5 1.9 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 2.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 0.9 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 1.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 1.8 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 0.6 GO:1990254 keratin filament binding(GO:1990254)
0.2 0.6 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 1.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 1.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 1.8 GO:0045296 cadherin binding(GO:0045296)
0.0 1.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 1.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 1.1 GO:0043531 ADP binding(GO:0043531)
0.0 0.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 3.1 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 0.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 2.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0048038 quinone binding(GO:0048038)
0.0 1.1 GO:0005125 cytokine activity(GO:0005125) growth factor activity(GO:0008083)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)