Motif ID: Foxa2_Foxa1

Z-value: 1.828

Transcription factors associated with Foxa2_Foxa1:

Gene SymbolEntrez IDGene Name
Foxa1 ENSMUSG00000035451.6 Foxa1
Foxa2 ENSMUSG00000037025.5 Foxa2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa1mm10_v2_chr12_-_57546121_575461410.094.9e-01Click!
Foxa2mm10_v2_chr2_-_148046896_1480469910.047.6e-01Click!


Activity profile for motif Foxa2_Foxa1.

activity profile for motif Foxa2_Foxa1


Sorted Z-values histogram for motif Foxa2_Foxa1

Sorted Z-values for motif Foxa2_Foxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48662740 28.586 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr5_+_75152274 27.209 ENSMUST00000000476.8
 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr12_-_56535047 23.294 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr6_+_5390387 22.564 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr17_-_70851710 18.995 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr7_+_113765998 18.340 ENSMUST00000046687.9
 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr18_-_47333311 15.858 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr14_+_73237891 15.752 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr2_-_172940299 14.525 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr4_-_58499398 14.517 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr1_+_12718496 14.313 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr2_+_25180737 13.694 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr5_+_16553488 13.335 ENSMUST00000030683.3
 Hgf
hepatocyte growth factor
chr4_+_11191726 12.657 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr7_+_113766119 12.497 ENSMUST00000084696.4
 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr11_-_68386821 11.964 ENSMUST00000021284.3
 Ntn1
netrin 1
chr2_+_14873656 11.675 ENSMUST00000114718.1
ENSMUST00000114719.1
 Cacnb2

calcium channel, voltage-dependent, beta 2 subunit

chr18_-_60501983 10.902 ENSMUST00000042710.6
 Smim3
small integral membrane protein 3
chr16_-_22439719 10.867 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr13_+_49582745 10.803 ENSMUST00000065494.7
 Omd
osteomodulin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.1 30.4 GO:0021759 globus pallidus development(GO:0021759)
0.9 29.7 GO:0006270 DNA replication initiation(GO:0006270)
7.1 28.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
9.1 27.2 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.8 26.3 GO:0007638 mechanosensory behavior(GO:0007638)
2.3 22.6 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
2.0 22.5 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
1.4 22.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
3.0 17.8 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.1 16.9 GO:0042060 wound healing(GO:0042060)
0.8 15.9 GO:2001224 positive regulation of neuron migration(GO:2001224)
4.8 14.5 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
3.6 14.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
3.6 14.3 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
1.2 13.7 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
1.7 13.3 GO:1902947 regulation of tau-protein kinase activity(GO:1902947)
0.6 13.3 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
2.5 12.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
4.1 12.2 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
3.9 11.7 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 70.4 GO:0031012 extracellular matrix(GO:0031012)
0.1 42.8 GO:0005667 transcription factor complex(GO:0005667)
0.4 29.9 GO:0005902 microvillus(GO:0005902)
0.1 23.2 GO:0030426 growth cone(GO:0030426)
5.6 22.6 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 22.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 21.3 GO:0005654 nucleoplasm(GO:0005654)
0.4 17.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 16.7 GO:0005887 integral component of plasma membrane(GO:0005887)
1.7 15.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 14.5 GO:0043198 dendritic shaft(GO:0043198)
0.1 13.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.4 13.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.2 11.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 10.0 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.6 8.8 GO:0042555 MCM complex(GO:0042555)
1.4 8.3 GO:0030870 Mre11 complex(GO:0030870)
0.1 8.0 GO:0017053 transcriptional repressor complex(GO:0017053)
1.9 7.5 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 7.3 GO:0043296 apical junction complex(GO:0043296)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 63.4 GO:0001159 core promoter proximal region DNA binding(GO:0001159)
2.7 31.9 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
5.4 27.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.4 21.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
3.2 19.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.9 19.0 GO:0070410 co-SMAD binding(GO:0070410)
4.7 18.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.8 18.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 15.7 GO:0005178 integrin binding(GO:0005178)
0.1 15.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.5 14.5 GO:0070700 BMP receptor binding(GO:0070700)
2.9 14.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.7 13.3 GO:0042056 chemoattractant activity(GO:0042056)
2.3 11.7 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.5 11.0 GO:0005521 lamin binding(GO:0005521)
1.1 10.9 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.3 10.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 9.9 GO:0017081 chloride channel regulator activity(GO:0017081)
0.2 9.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
3.2 9.7 GO:0008502 melatonin receptor activity(GO:0008502)