Motif ID: Foxa3
Z-value: 1.120
Transcription factors associated with Foxa3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxa3 | ENSMUSG00000040891.5 | Foxa3 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 13.8 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 1.3 | 9.4 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 1.1 | 3.4 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 1.1 | 4.4 | GO:0034285 | response to sucrose(GO:0009744) response to disaccharide(GO:0034285) |
| 0.9 | 3.6 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.8 | 7.1 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.7 | 8.8 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.7 | 3.4 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.6 | 2.3 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.5 | 5.4 | GO:0097421 | liver regeneration(GO:0097421) |
| 0.5 | 2.0 | GO:1901894 | regulation of calcium-transporting ATPase activity(GO:1901894) |
| 0.5 | 3.8 | GO:0097460 | positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) |
| 0.5 | 1.4 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 0.4 | 2.7 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.4 | 1.7 | GO:0009597 | detection of virus(GO:0009597) |
| 0.4 | 2.0 | GO:0060066 | oviduct development(GO:0060066) |
| 0.4 | 1.5 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.3 | 1.3 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.3 | 0.9 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.3 | 2.6 | GO:0010572 | positive regulation of platelet activation(GO:0010572) |
| 0.3 | 2.0 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.3 | 0.8 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.3 | 2.0 | GO:0045075 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 0.2 | 2.2 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.2 | 3.1 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.2 | 2.6 | GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191) |
| 0.2 | 1.1 | GO:0051012 | microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856) |
| 0.2 | 2.7 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.2 | 1.3 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.2 | 0.6 | GO:0030210 | heparin biosynthetic process(GO:0030210) |
| 0.2 | 0.9 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.2 | 2.6 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.2 | 2.3 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.2 | 16.1 | GO:0048663 | neuron fate commitment(GO:0048663) |
| 0.2 | 2.4 | GO:0001553 | luteinization(GO:0001553) |
| 0.2 | 0.7 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.2 | 1.5 | GO:0010820 | positive regulation of T cell chemotaxis(GO:0010820) |
| 0.2 | 0.5 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.2 | 1.5 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.2 | 0.9 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
| 0.1 | 0.4 | GO:0045763 | negative regulation of cellular amino acid metabolic process(GO:0045763) |
| 0.1 | 3.6 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.1 | 3.6 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 0.1 | 0.8 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 0.1 | 0.7 | GO:0090164 | asymmetric Golgi ribbon formation(GO:0090164) |
| 0.1 | 0.8 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 1.2 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.1 | 0.9 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.1 | 0.5 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 0.1 | 1.0 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.1 | 3.0 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.1 | 4.2 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.1 | 0.4 | GO:0015886 | heme transport(GO:0015886) |
| 0.1 | 0.3 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.1 | 0.3 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
| 0.1 | 1.4 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.1 | 1.1 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.1 | 0.5 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.1 | 0.3 | GO:0031509 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
| 0.1 | 1.2 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 1.7 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.1 | 0.7 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.1 | 1.4 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.1 | 1.2 | GO:0048643 | positive regulation of skeletal muscle tissue development(GO:0048643) |
| 0.0 | 2.0 | GO:0048843 | negative regulation of axon extension involved in axon guidance(GO:0048843) |
| 0.0 | 0.2 | GO:1903599 | positive regulation of mitophagy(GO:1903599) |
| 0.0 | 4.5 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 0.2 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.0 | 1.6 | GO:0030835 | negative regulation of actin filament depolymerization(GO:0030835) |
| 0.0 | 0.3 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.0 | 2.3 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 0.6 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 3.0 | GO:0043062 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.0 | 1.0 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.0 | 0.0 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 23.0 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 1.1 | 5.4 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.5 | 3.6 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
| 0.5 | 3.8 | GO:0097433 | dense body(GO:0097433) |
| 0.3 | 0.9 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.3 | 0.9 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.2 | 0.7 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.2 | 3.6 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.2 | 2.0 | GO:0043219 | catenin complex(GO:0016342) lateral loop(GO:0043219) |
| 0.1 | 1.3 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 2.2 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 3.0 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 2.0 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 2.3 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 1.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 4.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 1.5 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.1 | 22.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 1.4 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 8.5 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 1.3 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.1 | 1.2 | GO:0032281 | ionotropic glutamate receptor complex(GO:0008328) AMPA glutamate receptor complex(GO:0032281) neurotransmitter receptor complex(GO:0098878) |
| 0.1 | 0.5 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 20.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 4.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 1.6 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.3 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 0.3 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 2.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 8.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 0.9 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.1 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.0 | 2.5 | GO:0005768 | endosome(GO:0005768) |
| 0.0 | 3.4 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 1.1 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 1.0 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.7 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 11.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 4.7 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 6.1 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 0.4 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.3 | GO:0000788 | nuclear nucleosome(GO:0000788) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 23.0 | GO:0031721 | haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721) |
| 3.4 | 13.8 | GO:0004528 | phosphodiesterase I activity(GO:0004528) |
| 1.1 | 4.4 | GO:0097642 | calcitonin family receptor activity(GO:0097642) |
| 0.9 | 2.8 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.9 | 2.6 | GO:0050827 | toxin receptor binding(GO:0050827) |
| 0.6 | 9.4 | GO:0008430 | selenium binding(GO:0008430) |
| 0.5 | 3.8 | GO:0015091 | ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510) |
| 0.5 | 2.0 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.4 | 2.3 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.4 | 5.4 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.3 | 2.6 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.3 | 4.4 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.3 | 8.5 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.3 | 1.7 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.2 | 3.8 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.2 | 2.0 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.2 | 1.2 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 2.0 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.2 | 0.7 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.2 | 2.5 | GO:0010181 | FMN binding(GO:0010181) |
| 0.2 | 0.9 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 3.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 7.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 1.4 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 1.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 1.5 | GO:0070636 | single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694) |
| 0.1 | 1.4 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.1 | 0.4 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.1 | 3.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 0.9 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.1 | 3.0 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 0.7 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.1 | 1.5 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.1 | 0.4 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.1 | 1.0 | GO:0004438 | phosphatidylinositol-3-phosphatase activity(GO:0004438) |
| 0.1 | 1.1 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
| 0.1 | 0.8 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.1 | 0.8 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 2.3 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.1 | 3.6 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 0.5 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 2.0 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.6 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 0.8 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.0 | 2.2 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.3 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.0 | 3.5 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 3.0 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 0.8 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.2 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 1.3 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.5 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.3 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.0 | 2.1 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 1.3 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 0.5 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 3.6 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 4.0 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 0.7 | GO:0043531 | ADP binding(GO:0043531) |
| 0.0 | 2.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 0.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.9 | GO:0046332 | SMAD binding(GO:0046332) |
