Motif ID: Foxc1

Z-value: 0.875


Transcription factors associated with Foxc1:

Gene SymbolEntrez IDGene Name
Foxc1 ENSMUSG00000050295.2 Foxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc1mm10_v2_chr13_+_31806627_318066500.365.1e-03Click!


Activity profile for motif Foxc1.

activity profile for motif Foxc1


Sorted Z-values histogram for motif Foxc1

Sorted Z-values for motif Foxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 166 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 6.384 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr13_+_53525703 6.047 ENSMUST00000081132.4
 Gm5449
predicted pseudogene 5449
chr12_-_73047179 5.573 ENSMUST00000050029.7
 Six1
sine oculis-related homeobox 1
chr14_-_48662740 4.467 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr6_+_47244359 4.234 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr17_-_70851710 4.180 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr19_+_60144682 4.039 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr1_+_72824482 3.931 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr1_+_84839833 3.536 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chrY_+_1010543 3.535 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr1_-_71653162 3.478 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr9_+_72806874 3.425 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr10_+_77864623 3.346 ENSMUST00000092366.2
 Tspear
thrombospondin type laminin G domain and EAR repeats
chrX_-_102251852 3.128 ENSMUST00000101336.3
ENSMUST00000136277.1
 Cited1

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

chr16_-_46155077 3.105 ENSMUST00000059524.5
 Gm4737
predicted gene 4737
chr1_+_107511489 3.053 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chrX_-_102252154 2.997 ENSMUST00000050551.3
 Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr1_+_107511416 2.982 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr16_-_21947536 2.830 ENSMUST00000023562.7
 Tmem41a
transmembrane protein 41a
chr8_+_106870827 2.751 ENSMUST00000176144.1
ENSMUST00000175987.1
 Has3

hyaluronan synthase 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 6.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
1.5 6.1 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
1.9 5.6 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.2 5.5 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.0 5.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
1.1 4.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.8 4.2 GO:0071205 clustering of voltage-gated potassium channels(GO:0045163) protein localization to juxtaparanode region of axon(GO:0071205)
0.3 4.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.5 3.7 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
1.2 3.5 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161)
0.3 3.5 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.1 3.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 3.3 GO:0007605 sensory perception of sound(GO:0007605)
0.2 3.1 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 3.0 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.7 2.9 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.9 2.8 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.8 2.5 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.2 2.5 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.1 2.5 GO:0070286 axonemal dynein complex assembly(GO:0070286)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.0 GO:0005615 extracellular space(GO:0005615)
0.0 9.6 GO:0005667 transcription factor complex(GO:0005667)
0.5 6.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.2 3.5 GO:0005577 fibrinogen complex(GO:0005577)
0.2 3.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 3.1 GO:0032420 stereocilium(GO:0032420)
0.1 2.6 GO:0016235 aggresome(GO:0016235)
0.2 2.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 2.5 GO:0036064 ciliary basal body(GO:0036064)
0.7 2.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 2.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 2.0 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 1.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 1.7 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 1.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.2 1.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 1.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.4 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 6.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.8 6.1 GO:0050693 LBD domain binding(GO:0050693)
0.1 6.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 5.1 GO:0002020 protease binding(GO:0002020)
0.2 4.2 GO:0070410 co-SMAD binding(GO:0070410)
0.5 3.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.9 3.7 GO:0008142 oxysterol binding(GO:0008142)
0.0 3.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.6 3.5 GO:0045340 mercury ion binding(GO:0045340)
0.0 3.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 3.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.3 3.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 2.9 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.9 2.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.8 2.5 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.1 2.5 GO:0070402 NADPH binding(GO:0070402)
0.3 2.1 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 2.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)