Motif ID: Foxc2

Z-value: 0.458


Transcription factors associated with Foxc2:

Gene SymbolEntrez IDGene Name
Foxc2 ENSMUSG00000046714.6 Foxc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc2mm10_v2_chr8_+_121116163_121116177-0.085.7e-01Click!


Activity profile for motif Foxc2.

activity profile for motif Foxc2


Sorted Z-values histogram for motif Foxc2

Sorted Z-values for motif Foxc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 118 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 7.959 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr9_+_53850243 4.148 ENSMUST00000048485.5
 Sln
sarcolipin
chr11_+_32000452 3.906 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr4_+_48049080 3.748 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr1_+_177444653 3.551 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr17_+_70522083 3.432 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr2_-_62483637 3.316 ENSMUST00000136686.1
ENSMUST00000102733.3
 Gcg

glucagon

chr16_-_74411292 2.603 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr4_-_87806296 2.560 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr11_+_32000496 2.428 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chr3_-_123672321 2.421 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr17_+_70522149 2.313 ENSMUST00000140728.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr2_-_45110336 2.211 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr7_+_44849581 2.129 ENSMUST00000150335.1
ENSMUST00000107882.1
 Akt1s1

AKT1 substrate 1 (proline-rich)

chrX_+_163911401 1.991 ENSMUST00000140845.1
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr19_+_44992127 1.839 ENSMUST00000179305.1
 Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr4_+_97777606 1.837 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr12_-_108003414 1.836 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr13_+_42681513 1.824 ENSMUST00000149235.1
 Phactr1
phosphatase and actin regulator 1
chr1_-_97977233 1.730 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 6.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 5.7 GO:0070842 aggresome assembly(GO:0070842)
0.3 5.1 GO:0045792 negative regulation of cell size(GO:0045792)
1.0 4.1 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
1.2 3.7 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.4 3.6 GO:0007379 segment specification(GO:0007379)
0.0 3.6 GO:0021766 hippocampus development(GO:0021766)
0.5 3.3 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.5 3.0 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.9 2.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.4 2.2 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 2.0 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 1.8 GO:0050919 negative chemotaxis(GO:0050919)
0.2 1.7 GO:0009404 toxin metabolic process(GO:0009404)
0.5 1.6 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.1 1.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 1.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.7 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.5 5.1 GO:0031931 TORC1 complex(GO:0031931)
0.2 4.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 3.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 3.6 GO:0045171 intercellular bridge(GO:0045171)
0.1 2.6 GO:0030673 axolemma(GO:0030673)
0.0 2.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.7 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 1.4 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.3 GO:0016459 myosin complex(GO:0016459)
0.1 1.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.0 GO:0005802 trans-Golgi network(GO:0005802)
0.1 0.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.8 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.3 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 3.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 3.3 GO:0005179 hormone activity(GO:0005179)
0.3 2.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 2.2 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.8 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.6 1.7 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.3 1.6 GO:0071253 connexin binding(GO:0071253)
0.1 1.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.5 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 1.4 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 1.4 GO:0043531 ADP binding(GO:0043531)
0.0 1.3 GO:0008565 protein transporter activity(GO:0008565)
0.2 1.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 1.1 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 1.0 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 1.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)