Motif ID: Foxo3

Z-value: 0.997


Transcription factors associated with Foxo3:

Gene SymbolEntrez IDGene Name
Foxo3 ENSMUSG00000048756.5 Foxo3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276744_422767630.804.8e-14Click!


Activity profile for motif Foxo3.

activity profile for motif Foxo3


Sorted Z-values histogram for motif Foxo3

Sorted Z-values for motif Foxo3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo3

PNG image of the network

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Top targets:


Showing 1 to 20 of 94 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 24.027 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr14_-_51913393 15.420 ENSMUST00000004673.7
ENSMUST00000111632.3
 Ndrg2

N-myc downstream regulated gene 2

chr2_+_124610573 13.281 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr16_+_93683184 12.248 ENSMUST00000039620.6
 Cbr3
carbonyl reductase 3
chr11_+_3332426 7.537 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr11_-_101785252 7.014 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr2_+_124610278 6.784 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
 Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr8_+_71568866 6.386 ENSMUST00000034267.4
 Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr10_+_40349265 6.103 ENSMUST00000044672.4
ENSMUST00000095743.2
 Cdk19

cyclin-dependent kinase 19

chr10_+_112271123 5.658 ENSMUST00000092175.2
 Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr2_-_51972990 5.453 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr5_+_66968416 5.295 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr7_+_113765998 5.116 ENSMUST00000046687.9
 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr2_-_51973219 5.056 ENSMUST00000028314.2
 Nmi
N-myc (and STAT) interactor
chr11_-_60352869 4.488 ENSMUST00000095254.5
ENSMUST00000102683.4
ENSMUST00000093048.6
ENSMUST00000093046.6
ENSMUST00000064019.8
ENSMUST00000102682.4
 Tom1l2





target of myb1-like 2 (chicken)





chr10_-_93311073 4.114 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr10_-_93310963 4.087 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr16_-_22439719 3.959 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr7_-_103813913 3.921 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr7_+_113766119 3.915 ENSMUST00000084696.4
 Spon1
spondin 1, (f-spondin) extracellular matrix protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 24.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.7 20.1 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.4 15.4 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.8 13.3 GO:0042182 ketone catabolic process(GO:0042182)
1.6 11.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
3.5 10.5 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.0 8.2 GO:0031032 actomyosin structure organization(GO:0031032)
1.1 7.5 GO:1903726 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of phospholipid metabolic process(GO:1903726)
1.5 7.3 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
1.3 6.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.1 6.1 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.7 5.7 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.0 5.5 GO:0006897 endocytosis(GO:0006897)
0.1 4.5 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 4.2 GO:0042060 wound healing(GO:0042060)
0.2 3.9 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
1.2 3.5 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.2 3.4 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.4 3.0 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.5 2.7 GO:0046549 retinal cone cell development(GO:0046549)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 44.0 GO:0005654 nucleoplasm(GO:0005654)
0.0 12.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 6.7 GO:0043197 dendritic spine(GO:0043197)
0.0 6.7 GO:0005769 early endosome(GO:0005769)
0.2 5.7 GO:0030673 axolemma(GO:0030673)
0.0 5.3 GO:0005901 caveola(GO:0005901)
1.0 3.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 3.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.8 3.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 3.1 GO:0030139 endocytic vesicle(GO:0030139)
0.1 3.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 2.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.3 GO:0072562 blood microparticle(GO:0072562)
0.4 2.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 2.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.2 GO:0030027 lamellipodium(GO:0030027)
0.2 2.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 2.1 GO:0005811 lipid particle(GO:0005811)
0.0 1.5 GO:0005903 brush border(GO:0005903)
0.0 1.4 GO:0000786 nucleosome(GO:0000786)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.5 20.1 GO:0030215 semaphorin receptor binding(GO:0030215)
4.1 12.2 GO:0000253 3-keto sterol reductase activity(GO:0000253)
2.1 8.2 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
2.5 7.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 7.4 GO:0003779 actin binding(GO:0003779)
1.8 7.3 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.6 6.4 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 6.1 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.2 5.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 4.5 GO:0030276 clathrin binding(GO:0030276)
1.3 3.9 GO:0010698 acetyltransferase activator activity(GO:0010698)
1.0 3.9 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.9 3.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.6 3.0 GO:0097001 ceramide binding(GO:0097001)
0.9 2.7 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 2.7 GO:0005125 cytokine activity(GO:0005125)
0.8 2.3 GO:0001851 complement component C3b binding(GO:0001851)
0.0 2.3 GO:0019902 phosphatase binding(GO:0019902)
0.3 2.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)