Motif ID: Foxo4

Z-value: 1.014


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.462.2e-04Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_50030735 8.220 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr13_-_8940977 7.357 ENSMUST00000071184.2
 Rpl10a-ps2
ribosomal protein L10A, pseudogene 2
chr19_-_5796924 6.370 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr4_-_97778042 5.024 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr8_-_105943382 4.887 ENSMUST00000038896.7
 Lcat
lecithin cholesterol acyltransferase
chr17_+_78508063 4.109 ENSMUST00000024880.9
 Vit
vitrin
chr5_-_70842617 3.969 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr7_-_89517576 3.942 ENSMUST00000041761.5
 Prss23
protease, serine, 23
chr14_-_25903100 3.428 ENSMUST00000052286.8
 Plac9a
placenta specific 9a
chr2_-_175141999 3.359 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
 Gm14399


predicted gene 14399


chr8_-_45410539 3.324 ENSMUST00000034056.4
ENSMUST00000167106.1
 Tlr3

toll-like receptor 3

chr2_-_175931051 3.278 ENSMUST00000108949.2
ENSMUST00000109018.2
 Gm8898

predicted gene 8898

chr14_-_26182480 3.185 ENSMUST00000184142.1
 Plac9b
placenta specific 9b
chr15_-_97767798 3.171 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
 Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr2_+_176521056 2.963 ENSMUST00000108997.2
ENSMUST00000178443.1
 Gm14431

predicted gene 14431

chr2_+_177000956 2.963 ENSMUST00000108975.2
ENSMUST00000156844.1
 Gm14419

predicted gene 14419

chr2_-_175703646 2.839 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
 Gm4245


predicted gene 4245


chr2_+_175372436 2.799 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
 Gm4723


predicted gene 4723


chr2_+_175469985 2.768 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
 Gm8923



predicted gene 8923



chr6_+_95117740 2.718 ENSMUST00000032107.7
ENSMUST00000119582.1
 Kbtbd8

kelch repeat and BTB (POZ) domain containing 8


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 6.4 GO:0035063 nuclear speck organization(GO:0035063)
1.0 4.9 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 4.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.3 3.6 GO:0060539 diaphragm development(GO:0060539)
1.1 3.3 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.8 3.2 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.1 2.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 2.5 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.2 2.4 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 2.4 GO:0046888 negative regulation of hormone secretion(GO:0046888)
0.7 2.2 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.7 2.2 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.4 2.2 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.3 2.1 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.2 1.9 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 1.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 1.6 GO:0060074 synapse maturation(GO:0060074)
0.5 1.4 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 1.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0016607 nuclear speck(GO:0016607)
0.3 4.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.3 4.1 GO:0005614 interstitial matrix(GO:0005614)
0.8 3.2 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.2 2.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 2.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.4 2.1 GO:0005861 troponin complex(GO:0005861)
0.1 1.6 GO:0034707 chloride channel complex(GO:0034707)
0.2 1.2 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 1.2 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.2 1.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.6 GO:0001652 granular component(GO:0001652)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 4.9 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 4.1 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.2 4.0 GO:0050811 GABA receptor binding(GO:0050811)
0.1 3.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 3.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.4 3.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 2.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 2.2 GO:0044548 S100 protein binding(GO:0044548)
0.1 2.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.7 2.1 GO:0030172 troponin C binding(GO:0030172)
0.0 2.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 1.9 GO:0015026 coreceptor activity(GO:0015026)
0.0 1.7 GO:0008083 growth factor activity(GO:0008083)
0.1 1.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.5 1.4 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.3 1.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 1.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.9 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.9 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)