Motif ID: Foxo6

Z-value: 0.757


Transcription factors associated with Foxo6:

Gene SymbolEntrez IDGene Name
Foxo6 ENSMUSG00000052135.8 Foxo6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_120287349-0.872.5e-19Click!


Activity profile for motif Foxo6.

activity profile for motif Foxo6


Sorted Z-values histogram for motif Foxo6

Sorted Z-values for motif Foxo6



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 8.745 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr15_+_3270767 6.008 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr17_-_31277327 5.936 ENSMUST00000024832.7
 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr4_+_134510999 5.509 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr11_-_12027958 5.254 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr5_+_110330697 4.770 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr19_-_45742873 4.652 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr1_+_51987139 4.188 ENSMUST00000168302.1
 Stat4
signal transducer and activator of transcription 4
chr2_-_84425258 3.778 ENSMUST00000074262.2
 Calcrl
calcitonin receptor-like
chr1_+_74391479 3.486 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr14_-_47418407 3.143 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr11_+_85832551 3.088 ENSMUST00000000095.6
 Tbx2
T-box 2
chr5_-_99037035 3.077 ENSMUST00000031277.6
 Prkg2
protein kinase, cGMP-dependent, type II
chr13_-_71963713 3.057 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr5_+_7179299 3.044 ENSMUST00000179460.1
 Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chrX_+_106920618 2.982 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr9_+_6168638 2.944 ENSMUST00000058692.7
 Pdgfd
platelet-derived growth factor, D polypeptide
chrX_+_134585644 2.893 ENSMUST00000113211.1
 Rpl36a
ribosomal protein L36A
chr18_-_60648290 2.816 ENSMUST00000143275.2
 Synpo
synaptopodin
chr5_-_117389029 2.769 ENSMUST00000111953.1
ENSMUST00000086461.6
 Rfc5

replication factor C (activator 1) 5

chr10_-_93310963 2.650 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr7_-_123369870 2.551 ENSMUST00000106442.2
ENSMUST00000098060.3
ENSMUST00000167309.1
 Arhgap17


Rho GTPase activating protein 17


chr11_-_89639631 2.543 ENSMUST00000128717.1
 Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr12_-_91384403 2.513 ENSMUST00000141429.1
 Cep128
centrosomal protein 128
chr2_+_129593195 2.420 ENSMUST00000099113.3
ENSMUST00000103202.3
 Sirpa

signal-regulatory protein alpha

chr1_-_184883218 2.414 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr11_+_46235460 2.358 ENSMUST00000060185.2
 Fndc9
fibronectin type III domain containing 9
chr7_+_28808795 2.205 ENSMUST00000172529.1
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chrY_-_6681243 1.996 ENSMUST00000115940.1
 Gm21719
predicted gene, 21719
chr17_-_24696147 1.941 ENSMUST00000046839.8
 Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr2_+_4718145 1.883 ENSMUST00000056914.6
 Bend7
BEN domain containing 7
chr2_-_67194695 1.858 ENSMUST00000147939.1
 Gm13598
predicted gene 13598
chr2_+_129592914 1.831 ENSMUST00000103203.1
 Sirpa
signal-regulatory protein alpha
chrX_-_163761323 1.670 ENSMUST00000059320.2
 Rnf138rt1
ring finger protein 138, retrogene 1
chr1_-_160077918 1.632 ENSMUST00000028061.3
 4930562F07Rik
RIKEN cDNA 4930562F07 gene
chr12_+_108410625 1.615 ENSMUST00000109857.1
 Eml1
echinoderm microtubule associated protein like 1
chr5_-_65391408 1.609 ENSMUST00000057885.6
 Rpl9
ribosomal protein L9
chr10_-_93311073 1.601 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr12_+_108410542 1.563 ENSMUST00000054955.7
 Eml1
echinoderm microtubule associated protein like 1
chrX_-_8193387 1.557 ENSMUST00000143223.1
ENSMUST00000033509.8
 Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr19_+_44293676 1.540 ENSMUST00000026221.5
 Scd2
stearoyl-Coenzyme A desaturase 2
chr5_-_65391380 1.371 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
 Rpl9


ribosomal protein L9


chr18_+_5593566 1.366 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr10_+_29313164 1.358 ENSMUST00000160399.1
 Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr11_+_87853207 1.235 ENSMUST00000038196.6
 Mks1
Meckel syndrome, type 1
chr3_-_49757257 1.232 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr7_+_28440927 1.163 ENSMUST00000078845.6
 Gmfg
glia maturation factor, gamma
chr2_-_11603192 1.152 ENSMUST00000040314.5
 Rbm17
RNA binding motif protein 17
chr7_+_140881898 1.113 ENSMUST00000026560.7
 Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr17_-_57839233 1.090 ENSMUST00000095218.3
 Rpl7a-ps5
ribosomal protein L7A, pseudogene 5
chr1_-_162898665 1.065 ENSMUST00000111510.1
ENSMUST00000045902.6
 Fmo2

flavin containing monooxygenase 2

chr3_-_34351685 1.027 ENSMUST00000174114.1
 Gm20514
predicted gene 20514
chr14_-_50924626 0.996 ENSMUST00000160375.1
ENSMUST00000162177.1
ENSMUST00000159292.1
 Osgep


O-sialoglycoprotein endopeptidase


chr7_+_64287665 0.986 ENSMUST00000032736.4
 Mtmr10
myotubularin related protein 10
chr5_-_52190484 0.960 ENSMUST00000031061.7
 Dhx15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr7_+_143052739 0.857 ENSMUST00000037941.9
 Cd81
CD81 antigen
chr3_+_103968110 0.818 ENSMUST00000117150.1
ENSMUST00000063717.7
ENSMUST00000055425.8
ENSMUST00000123611.1
ENSMUST00000090685.4
 Phtf1




putative homeodomain transcription factor 1




chr8_+_46986913 0.772 ENSMUST00000039840.7
ENSMUST00000119686.1
 Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr2_-_155357392 0.767 ENSMUST00000165234.1
ENSMUST00000077626.6
 Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chr1_+_110099295 0.764 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr15_-_75111684 0.752 ENSMUST00000100542.3
 Ly6c2
lymphocyte antigen 6 complex, locus C2
chr17_+_25471564 0.712 ENSMUST00000025002.1
 Tekt4
tektin 4
chr7_+_19368498 0.690 ENSMUST00000132655.1
 Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr15_+_52712434 0.689 ENSMUST00000037115.7
 Med30
mediator complex subunit 30
chr14_+_34170640 0.662 ENSMUST00000104925.3
 Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr18_-_12305638 0.585 ENSMUST00000122408.1
ENSMUST00000118525.1
ENSMUST00000142066.1
 Ankrd29


ankyrin repeat domain 29


chr5_+_44100442 0.555 ENSMUST00000072800.4
 Gm16401
predicted gene 16401
chr5_+_65391497 0.523 ENSMUST00000031101.3
ENSMUST00000122026.1
 Lias

lipoic acid synthetase

chr19_+_8892987 0.395 ENSMUST00000096249.5
 Ints5
integrator complex subunit 5
chr6_+_88724667 0.392 ENSMUST00000163271.1
 Mgll
monoglyceride lipase
chr16_+_10812915 0.295 ENSMUST00000115822.1
 Gm11172
predicted gene 11172
chr4_+_62286441 0.230 ENSMUST00000084530.2
 Slc31a2
solute carrier family 31, member 2
chr12_-_102423741 0.221 ENSMUST00000110020.1
 Lgmn
legumain
chr2_-_75978164 0.214 ENSMUST00000099995.3
 Ttc30a2
tetratricopeptide repeat domain 30A2
chr1_-_180245927 0.212 ENSMUST00000010753.7
 Psen2
presenilin 2
chr1_-_180245757 0.188 ENSMUST00000111104.1
 Psen2
presenilin 2
chr3_-_106167564 0.186 ENSMUST00000063062.8
 Chi3l3
chitinase 3-like 3
chr5_+_115279666 0.122 ENSMUST00000040421.4
 Coq5
coenzyme Q5 homolog, methyltransferase (yeast)
chr2_-_93046053 0.030 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
 Prdm11


PR domain containing 11


chr12_-_113260217 0.015 ENSMUST00000178282.1
 Igha
immunoglobulin heavy constant alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
1.5 8.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.0 3.1 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
1.0 2.9 GO:0035696 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.9 3.8 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.9 6.0 GO:0001887 selenium compound metabolic process(GO:0001887)
0.8 4.8 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.6 5.3 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.4 1.5 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.3 2.8 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.3 2.2 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.3 2.5 GO:0050957 equilibrioception(GO:0050957)
0.3 3.1 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.3 1.1 GO:0072592 oxygen metabolic process(GO:0072592)
0.2 1.0 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.2 0.9 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.2 1.2 GO:1903887 motile primary cilium assembly(GO:1903887)
0.2 1.4 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.2 1.9 GO:1903204 liver regeneration(GO:0097421) negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.2 1.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.2 0.5 GO:0009106 lipoate metabolic process(GO:0009106)
0.2 4.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 5.9 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.8 GO:0019695 choline metabolic process(GO:0019695)
0.1 0.8 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.7 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.1 1.1 GO:0043248 proteasome assembly(GO:0043248)
0.1 2.6 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.1 1.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 3.5 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 8.7 GO:0007051 spindle organization(GO:0007051)
0.1 0.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 0.7 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 3.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.4 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 1.6 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 2.6 GO:0017156 calcium ion regulated exocytosis(GO:0017156)
0.0 1.2 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 1.7 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.4 GO:0016180 snRNA processing(GO:0016180)
0.0 0.7 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 4.3 GO:0042060 wound healing(GO:0042060)
0.0 3.1 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.7 5.9 GO:0001520 outer dense fiber(GO:0001520)
0.5 2.8 GO:0005663 DNA replication factor C complex(GO:0005663)
0.3 1.0 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.3 1.0 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.3 3.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.2 3.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.8 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 1.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 2.2 GO:0045120 pronucleus(GO:0045120)
0.1 8.0 GO:0000922 spindle pole(GO:0000922)
0.1 5.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.2 GO:0036038 MKS complex(GO:0036038)
0.1 0.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.7 GO:0097228 sperm midpiece(GO:0097225) sperm principal piece(GO:0097228)
0.0 5.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.4 GO:0032039 integrator complex(GO:0032039)
0.0 0.4 GO:0043196 varicosity(GO:0043196)
0.0 0.9 GO:0001772 immunological synapse(GO:0001772)
0.0 4.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 3.5 GO:0031965 nuclear membrane(GO:0031965)
0.0 4.5 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
1.1 4.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.9 3.8 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.8 3.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.5 1.6 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.5 3.0 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.5 1.9 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.5 1.4 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.4 6.0 GO:0008430 selenium binding(GO:0008430)
0.4 3.5 GO:0008420 CTD phosphatase activity(GO:0008420)
0.4 1.5 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.3 1.0 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.3 2.8 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 5.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 2.2 GO:1990715 mRNA CDS binding(GO:1990715)
0.2 1.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 4.3 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.2 2.9 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.2 0.8 GO:0034235 GPI anchor binding(GO:0034235)
0.1 1.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 2.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.8 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.9 GO:1990459 transferrin receptor binding(GO:1990459)
0.1 13.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 0.5 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 1.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 3.0 GO:0019843 rRNA binding(GO:0019843)
0.0 0.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 3.0 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 1.0 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)