Motif ID: Foxp2_Foxp3

Z-value: 0.626

Transcription factors associated with Foxp2_Foxp3:

Gene SymbolEntrez IDGene Name
Foxp2 ENSMUSG00000029563.10 Foxp2
Foxp3 ENSMUSG00000039521.6 Foxp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxp2mm10_v2_chr6_+_15196949_151971020.383.2e-03Click!
Foxp3mm10_v2_chrX_+_7579666_7579693-0.246.9e-02Click!


Activity profile for motif Foxp2_Foxp3.

activity profile for motif Foxp2_Foxp3


Sorted Z-values histogram for motif Foxp2_Foxp3

Sorted Z-values for motif Foxp2_Foxp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxp2_Foxp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_66386292 5.538 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr1_+_66386968 3.210 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr15_+_3270767 3.197 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr10_+_60106452 2.994 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr6_+_141524379 2.523 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr1_+_19212054 2.480 ENSMUST00000064976.4
 Tfap2b
transcription factor AP-2 beta
chr6_-_148444336 2.417 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr4_+_144892813 2.284 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr11_+_3332426 2.258 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr11_+_69095217 2.128 ENSMUST00000101004.2
 Per1
period circadian clock 1
chr3_+_5218516 2.067 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr19_+_4855129 1.978 ENSMUST00000119694.1
 Ctsf
cathepsin F
chr1_+_34005872 1.907 ENSMUST00000182296.1
 Dst
dystonin
chr6_+_135362931 1.880 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr3_+_5218589 1.782 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr2_-_65529275 1.723 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr5_+_28165690 1.689 ENSMUST00000036177.7
 En2
engrailed 2
chr7_+_110772604 1.685 ENSMUST00000005829.6
 Ampd3
adenosine monophosphate deaminase 3
chr4_+_144893077 1.662 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr7_+_82175156 1.623 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.5 5.3 GO:0042572 retinol metabolic process(GO:0042572)
0.3 4.2 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 3.5 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 3.3 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.5 3.2 GO:0001887 selenium compound metabolic process(GO:0001887)
0.2 3.2 GO:0070842 aggresome assembly(GO:0070842)
0.4 3.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3 3.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.8 2.5 GO:0097274 urea homeostasis(GO:0097274)
0.2 2.4 GO:0097421 liver regeneration(GO:0097421)
0.2 2.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 2.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 2.3 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 2.2 GO:0051764 actin crosslink formation(GO:0051764)
0.5 2.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.7 2.0 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 1.9 GO:0032060 bleb assembly(GO:0032060)
0.4 1.8 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.2 1.8 GO:0048625 myoblast fate commitment(GO:0048625)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 5.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.2 5.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 4.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.4 3.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 2.9 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 2.8 GO:0016605 PML body(GO:0016605)
0.6 2.4 GO:0044307 dendritic branch(GO:0044307)
0.1 2.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.6 2.3 GO:0031673 H zone(GO:0031673)
0.4 2.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 2.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 2.1 GO:0031941 filamentous actin(GO:0031941)
0.1 2.0 GO:0035861 site of double-strand break(GO:0035861)
0.0 2.0 GO:0030426 growth cone(GO:0030426)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.7 GO:0005769 early endosome(GO:0005769)
0.4 1.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 1.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 4.8 GO:0042287 MHC protein binding(GO:0042287)
0.4 3.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 3.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 3.2 GO:0008430 selenium binding(GO:0008430)
1.0 3.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 3.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.6 2.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 2.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 2.3 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.5 2.1 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 2.1 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 2.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 1.8 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 1.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2 1.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 1.6 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.1 1.5 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 1.5 GO:0005178 integrin binding(GO:0005178)
0.0 1.5 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)