Motif ID: Gata2_Gata1

Z-value: 1.408

Transcription factors associated with Gata2_Gata1:

Gene SymbolEntrez IDGene Name
Gata1 ENSMUSG00000031162.8 Gata1
Gata2 ENSMUSG00000015053.8 Gata2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata1mm10_v2_chrX_-_7967817_79679100.783.9e-13Click!
Gata2mm10_v2_chr6_+_88198656_881986750.383.1e-03Click!


Activity profile for motif Gata2_Gata1.

activity profile for motif Gata2_Gata1


Sorted Z-values histogram for motif Gata2_Gata1

Sorted Z-values for motif Gata2_Gata1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata2_Gata1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 156 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_32276400 52.845 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_+_32276893 45.945 ENSMUST00000145569.1
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr3_-_154330543 20.675 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr19_-_42202150 18.336 ENSMUST00000018966.7
 Sfrp5
secreted frizzled-related sequence protein 5
chr3_+_135825788 16.659 ENSMUST00000167390.1
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr7_-_99238564 16.222 ENSMUST00000064231.7
 Mogat2
monoacylglycerol O-acyltransferase 2
chrX_+_150547375 13.953 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chr7_-_139582790 12.722 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr9_-_32541589 12.016 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr17_+_36869567 11.915 ENSMUST00000060524.9
 Trim10
tripartite motif-containing 10
chr13_+_38345716 11.084 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr2_-_153241402 11.018 ENSMUST00000056924.7
 Plagl2
pleiomorphic adenoma gene-like 2
chr13_-_116309639 10.277 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr7_-_4522427 10.170 ENSMUST00000098859.3
 Tnni3
troponin I, cardiac 3
chr6_+_30541582 10.163 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr17_-_84682932 10.160 ENSMUST00000066175.3
 Abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr9_-_44342332 9.540 ENSMUST00000097558.3
 Hmbs
hydroxymethylbilane synthase
chr11_+_90030295 9.334 ENSMUST00000092788.3
 Tmem100
transmembrane protein 100
chr1_+_45311538 9.312 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr4_-_46404224 9.234 ENSMUST00000107764.2
 Hemgn
hemogen

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
19.8 98.8 GO:0015671 oxygen transport(GO:0015671)
2.5 25.2 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.3 20.7 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
6.1 18.3 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
2.4 16.8 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
2.8 16.6 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
1.8 16.4 GO:0006071 glycerol metabolic process(GO:0006071)
0.6 14.7 GO:0006783 heme biosynthetic process(GO:0006783)
1.4 14.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
1.8 12.7 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
2.1 12.5 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.5 12.0 GO:0035855 megakaryocyte development(GO:0035855)
0.1 11.4 GO:0030168 platelet activation(GO:0030168)
0.7 11.0 GO:0034377 plasma lipoprotein particle assembly(GO:0034377)
0.8 10.8 GO:0046697 decidualization(GO:0046697)
3.4 10.3 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.6 10.3 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
3.4 10.2 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
1.0 9.5 GO:0018065 protein-cofactor linkage(GO:0018065)
1.9 9.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
12.3 98.8 GO:0005833 hemoglobin complex(GO:0005833)
0.0 33.3 GO:0005576 extracellular region(GO:0005576)
3.4 20.7 GO:0001674 female germ cell nucleus(GO:0001674)
3.3 16.6 GO:0005861 troponin complex(GO:0005861)
0.1 14.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 10.3 GO:0005887 integral component of plasma membrane(GO:0005887)
1.0 10.2 GO:0098533 ATPase dependent transmembrane transport complex(GO:0098533)
0.7 9.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 9.3 GO:0043204 perikaryon(GO:0043204)
0.0 8.5 GO:0005667 transcription factor complex(GO:0005667)
0.5 8.4 GO:0031528 microvillus membrane(GO:0031528)
0.1 8.2 GO:0000793 condensed chromosome(GO:0000793)
0.1 7.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 6.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
1.3 6.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 6.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.5 5.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.3 5.1 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 4.7 GO:0031965 nuclear membrane(GO:0031965)
0.1 4.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
19.8 98.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.9 25.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 21.0 GO:0008270 zinc ion binding(GO:0008270)
0.8 18.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
5.5 16.6 GO:0030172 troponin C binding(GO:0030172)
5.4 16.2 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.3 15.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.9 14.0 GO:0016594 glycine binding(GO:0016594)
0.0 13.5 GO:0008022 protein C-terminus binding(GO:0008022)
4.2 12.5 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 12.5 GO:0003682 chromatin binding(GO:0003682)
0.1 12.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 11.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.1 11.1 GO:0070700 BMP receptor binding(GO:0070700)
0.6 10.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.6 9.5 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.6 9.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 8.5 GO:0050699 WW domain binding(GO:0050699)
0.2 8.0 GO:0001540 beta-amyloid binding(GO:0001540)
2.0 7.8 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)