Motif ID: Gbx1_Nobox_Alx3

Z-value: 0.721

Transcription factors associated with Gbx1_Nobox_Alx3:

Gene SymbolEntrez IDGene Name
Alx3 ENSMUSG00000014603.1 Alx3
Gbx1 ENSMUSG00000067724.4 Gbx1
Nobox ENSMUSG00000029736.9 Nobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx1mm10_v2_chr5_-_24527276_245272760.471.8e-04Click!
Alx3mm10_v2_chr3_+_107595031_1075951640.429.3e-04Click!


Activity profile for motif Gbx1_Nobox_Alx3.

activity profile for motif Gbx1_Nobox_Alx3


Sorted Z-values histogram for motif Gbx1_Nobox_Alx3

Sorted Z-values for motif Gbx1_Nobox_Alx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx1_Nobox_Alx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 9.228 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_+_109917639 8.137 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr3_+_159839729 7.219 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr2_-_168767029 7.184 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr5_-_62765618 6.084 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_124779686 5.760 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr3_+_122419772 5.109 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr18_+_23415400 5.055 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr13_-_102906046 4.973 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102905740 4.957 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr3_+_134236483 4.692 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr1_-_190170671 4.496 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr18_+_56432116 4.471 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr2_-_168767136 4.457 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr14_-_48662740 4.311 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr12_+_38780284 4.221 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr6_+_125552948 4.203 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr2_+_152754156 4.133 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr15_+_25773985 4.106 ENSMUST00000125667.1
 Myo10
myosin X
chr1_+_104768510 4.092 ENSMUST00000062528.8
 Cdh20
cadherin 20

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.4 GO:0007638 mechanosensory behavior(GO:0007638)
0.6 11.6 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.2 9.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
2.7 8.1 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.6 7.2 GO:0031017 exocrine pancreas development(GO:0031017)
0.8 6.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
2.0 6.1 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 6.0 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.1 5.5 GO:0001889 liver development(GO:0001889)
0.2 5.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 5.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 5.0 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 4.5 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
1.1 4.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.7 4.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 4.0 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.0 4.0 GO:0008360 regulation of cell shape(GO:0008360)
0.1 3.7 GO:0006907 pinocytosis(GO:0006907)
0.0 3.6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.4 3.1 GO:0060872 semicircular canal morphogenesis(GO:0048752) semicircular canal development(GO:0060872)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.1 GO:0000792 heterochromatin(GO:0000792)
0.0 7.3 GO:0005667 transcription factor complex(GO:0005667)
0.2 7.2 GO:0032590 dendrite membrane(GO:0032590)
0.4 6.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 5.0 GO:0016607 nuclear speck(GO:0016607)
0.0 4.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 4.3 GO:0016459 myosin complex(GO:0016459)
0.8 4.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 4.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.5 4.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 3.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 3.1 GO:0005915 zonula adherens(GO:0005915)
0.1 3.1 GO:0031201 SNARE complex(GO:0031201)
0.1 2.9 GO:0002102 podosome(GO:0002102)
0.0 2.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 2.5 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 2.5 GO:0005902 microvillus(GO:0005902)
0.1 2.4 GO:0043034 costamere(GO:0043034)
0.0 2.3 GO:0016528 sarcoplasm(GO:0016528)
0.0 1.9 GO:0008023 transcription elongation factor complex(GO:0008023)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 22.8 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 20.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 10.3 GO:0030165 PDZ domain binding(GO:0030165)
0.1 9.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 8.6 GO:0000287 magnesium ion binding(GO:0000287)
0.7 8.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 7.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.7 7.4 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.9 6.2 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.8 6.1 GO:0050693 LBD domain binding(GO:0050693)
0.7 6.1 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 5.8 GO:0005525 GTP binding(GO:0005525)
0.2 5.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 4.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 4.4 GO:0030507 spectrin binding(GO:0030507)
0.0 3.8 GO:0003779 actin binding(GO:0003779)
0.2 3.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 3.6 GO:0002039 p53 binding(GO:0002039)
0.0 3.1 GO:0019905 syntaxin binding(GO:0019905)
0.3 3.0 GO:0070097 delta-catenin binding(GO:0070097)