Motif ID: Gbx2

Z-value: 0.491


Transcription factors associated with Gbx2:

Gene SymbolEntrez IDGene Name
Gbx2 ENSMUSG00000034486.7 Gbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx2mm10_v2_chr1_-_89933290_89933290-0.029.0e-01Click!


Activity profile for motif Gbx2.

activity profile for motif Gbx2


Sorted Z-values histogram for motif Gbx2

Sorted Z-values for motif Gbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_48667508 6.225 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
Otx2



orthodenticle homolog 2 (Drosophila)



chr11_+_59306920 4.585 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr19_-_59170978 4.565 ENSMUST00000172821.2
Vax1
ventral anterior homeobox containing gene 1
chr18_+_56432116 3.342 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr11_-_79504078 2.699 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr12_+_79297345 2.597 ENSMUST00000079533.5
ENSMUST00000171210.1
Rad51b

RAD51 homolog B

chr3_-_141982224 2.594 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr7_-_30664986 2.481 ENSMUST00000019697.8
Haus5
HAUS augmin-like complex, subunit 5
chr2_+_152754156 2.348 ENSMUST00000010020.5
Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr3_-_116129615 2.080 ENSMUST00000029574.8
Vcam1
vascular cell adhesion molecule 1
chr7_+_75455534 2.025 ENSMUST00000147005.1
ENSMUST00000166315.1
Akap13

A kinase (PRKA) anchor protein 13

chr13_-_97747373 1.958 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_-_22439719 1.908 ENSMUST00000079601.6
Etv5
ets variant gene 5
chrX_+_106920618 1.875 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr1_-_128102412 1.862 ENSMUST00000112538.1
ENSMUST00000086614.5
Zranb3

zinc finger, RAN-binding domain containing 3

chr17_-_48432723 1.727 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr19_+_23723279 1.433 ENSMUST00000067077.1
Gm9938
predicted gene 9938
chr10_-_95501921 1.385 ENSMUST00000075829.2
Mrpl42
mitochondrial ribosomal protein L42
chr11_-_21370452 1.327 ENSMUST00000102875.4
Ugp2
UDP-glucose pyrophosphorylase 2
chr12_+_111814170 1.215 ENSMUST00000021714.7
Zfyve21
zinc finger, FYVE domain containing 21
chr3_+_94372794 1.166 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr13_+_23763660 1.136 ENSMUST00000055770.1
Hist1h1a
histone cluster 1, H1a
chr3_+_152714094 1.124 ENSMUST00000159899.1
ENSMUST00000045029.8
Pigk

phosphatidylinositol glycan anchor biosynthesis, class K

chr16_+_44394771 1.104 ENSMUST00000099742.2
Wdr52
WD repeat domain 52
chr1_-_175625580 1.094 ENSMUST00000027810.7
Fh1
fumarate hydratase 1
chr11_-_5878207 1.029 ENSMUST00000102922.3
Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr7_+_28810886 0.925 ENSMUST00000038572.8
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr7_-_78783026 0.900 ENSMUST00000032841.5
Mrpl46
mitochondrial ribosomal protein L46
chr9_+_96258697 0.774 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr13_+_49544443 0.738 ENSMUST00000177948.1
ENSMUST00000021820.6
Aspn

asporin

chr14_+_69347587 0.716 ENSMUST00000064831.5
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr11_-_45955183 0.676 ENSMUST00000109254.1
Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr12_-_98259416 0.676 ENSMUST00000021390.7
Galc
galactosylceramidase
chr13_+_31806627 0.605 ENSMUST00000062292.2
Foxc1
forkhead box C1
chr18_-_67245818 0.567 ENSMUST00000073054.3
Mppe1
metallophosphoesterase 1
chr3_+_96645579 0.543 ENSMUST00000119365.1
ENSMUST00000029744.5
Itga10

integrin, alpha 10

chr11_+_97315716 0.541 ENSMUST00000019026.3
ENSMUST00000132168.1
Mrpl45

mitochondrial ribosomal protein L45

chrX_-_56598069 0.539 ENSMUST00000059899.2
Mmgt1
membrane magnesium transporter 1
chr8_-_21906412 0.521 ENSMUST00000051965.4
Defb11
defensin beta 11
chr5_+_115341225 0.514 ENSMUST00000031508.4
Triap1
TP53 regulated inhibitor of apoptosis 1
chr2_+_27079371 0.489 ENSMUST00000091233.6
Adamtsl2
ADAMTS-like 2
chr5_-_5266038 0.387 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
Cdk14


cyclin-dependent kinase 14


chr1_+_71652837 0.379 ENSMUST00000097699.2
Apol7d
apolipoprotein L 7d
chrM_-_14060 0.343 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr19_-_32196393 0.338 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr7_+_78783119 0.294 ENSMUST00000032840.4
Mrps11
mitochondrial ribosomal protein S11
chr3_-_10331358 0.274 ENSMUST00000065938.8
ENSMUST00000118410.1
Impa1

inositol (myo)-1(or 4)-monophosphatase 1

chr10_+_128083273 0.266 ENSMUST00000026459.5
Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr13_-_97747399 0.261 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr2_-_73580288 0.231 ENSMUST00000028515.3
Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr1_-_4785671 0.201 ENSMUST00000130201.1
ENSMUST00000156816.1
Mrpl15

mitochondrial ribosomal protein L15

chr4_-_129261394 0.197 ENSMUST00000145261.1
C77080
expressed sequence C77080
chr3_-_89998656 0.165 ENSMUST00000079724.4
Hax1
HCLS1 associated X-1
chr1_+_24005505 0.116 ENSMUST00000181961.1
Gm26524
predicted gene, 26524
chr14_+_58893465 0.033 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.6 2.6 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.6 2.6 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.6 1.9 GO:0036292 DNA rewinding(GO:0036292)
0.6 4.6 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.4 1.3 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.4 2.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 1.9 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.4 1.1 GO:0006106 fumarate metabolic process(GO:0006106)
0.3 2.0 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.2 0.7 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.2 0.6 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.2 1.2 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.2 2.1 GO:0061032 chorio-allantoic fusion(GO:0060710) visceral serous pericardium development(GO:0061032)
0.2 1.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 4.6 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.7 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.9 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.1 2.7 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 0.7 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 1.7 GO:0080111 DNA demethylation(GO:0080111)
0.1 0.3 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 0.5 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.5 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.2 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.5 GO:0060481 lobar bronchus epithelium development(GO:0060481) lobar bronchus development(GO:0060482)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 2.5 GO:0051225 spindle assembly(GO:0051225)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.2 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.7 GO:0006400 tRNA modification(GO:0006400)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.3 1.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 2.5 GO:0070652 HAUS complex(GO:0070652)
0.3 2.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 2.1 GO:0002102 podosome(GO:0002102)
0.1 0.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 1.1 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 1.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.9 GO:0043596 nuclear replication fork(GO:0043596)
0.0 3.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.9 GO:0045120 pronucleus(GO:0045120)
0.0 0.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 6.2 GO:0030426 growth cone(GO:0030426)
0.0 2.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.3 GO:0070469 respiratory chain(GO:0070469)
0.0 5.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.6 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.5 2.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.4 2.6 GO:0000150 recombinase activity(GO:0000150)
0.3 1.9 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.3 1.2 GO:0008142 oxysterol binding(GO:0008142)
0.3 2.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 1.9 GO:0036310 annealing helicase activity(GO:0036310)
0.1 0.5 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.5 GO:0050436 microfibril binding(GO:0050436)
0.1 1.3 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.1 2.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 4.6 GO:0005109 frizzled binding(GO:0005109)
0.1 0.7 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 2.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.9 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 0.3 GO:0031403 lithium ion binding(GO:0031403)
0.1 0.5 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 0.7 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.1 0.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.5 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.1 0.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 1.7 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.6 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.1 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 6.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.1 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.7 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)