Motif ID: Gbx2

Z-value: 0.491


Transcription factors associated with Gbx2:

Gene SymbolEntrez IDGene Name
Gbx2 ENSMUSG00000034486.7 Gbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx2mm10_v2_chr1_-_89933290_89933290-0.029.0e-01Click!


Activity profile for motif Gbx2.

activity profile for motif Gbx2


Sorted Z-values histogram for motif Gbx2

Sorted Z-values for motif Gbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_48667508 6.225 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr11_+_59306920 4.585 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr19_-_59170978 4.565 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr18_+_56432116 3.342 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr11_-_79504078 2.699 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr12_+_79297345 2.597 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr3_-_141982224 2.594 ENSMUST00000029948.8
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr7_-_30664986 2.481 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr2_+_152754156 2.348 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr3_-_116129615 2.080 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr7_+_75455534 2.025 ENSMUST00000147005.1
ENSMUST00000166315.1
 Akap13

A kinase (PRKA) anchor protein 13

chr13_-_97747373 1.958 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_-_22439719 1.908 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chrX_+_106920618 1.875 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr1_-_128102412 1.862 ENSMUST00000112538.1
ENSMUST00000086614.5
 Zranb3

zinc finger, RAN-binding domain containing 3

chr17_-_48432723 1.727 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr19_+_23723279 1.433 ENSMUST00000067077.1
 Gm9938
predicted gene 9938
chr10_-_95501921 1.385 ENSMUST00000075829.2
 Mrpl42
mitochondrial ribosomal protein L42
chr11_-_21370452 1.327 ENSMUST00000102875.4
 Ugp2
UDP-glucose pyrophosphorylase 2
chr12_+_111814170 1.215 ENSMUST00000021714.7
 Zfyve21
zinc finger, FYVE domain containing 21
chr3_+_94372794 1.166 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr13_+_23763660 1.136 ENSMUST00000055770.1
 Hist1h1a
histone cluster 1, H1a
chr3_+_152714094 1.124 ENSMUST00000159899.1
ENSMUST00000045029.8
 Pigk

phosphatidylinositol glycan anchor biosynthesis, class K

chr16_+_44394771 1.104 ENSMUST00000099742.2
 Wdr52
WD repeat domain 52
chr1_-_175625580 1.094 ENSMUST00000027810.7
 Fh1
fumarate hydratase 1
chr11_-_5878207 1.029 ENSMUST00000102922.3
 Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr7_+_28810886 0.925 ENSMUST00000038572.8
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr7_-_78783026 0.900 ENSMUST00000032841.5
 Mrpl46
mitochondrial ribosomal protein L46
chr9_+_96258697 0.774 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr13_+_49544443 0.738 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr14_+_69347587 0.716 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr11_-_45955183 0.676 ENSMUST00000109254.1
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr12_-_98259416 0.676 ENSMUST00000021390.7
 Galc
galactosylceramidase
chr13_+_31806627 0.605 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr18_-_67245818 0.567 ENSMUST00000073054.3
 Mppe1
metallophosphoesterase 1
chr3_+_96645579 0.543 ENSMUST00000119365.1
ENSMUST00000029744.5
 Itga10

integrin, alpha 10

chr11_+_97315716 0.541 ENSMUST00000019026.3
ENSMUST00000132168.1
 Mrpl45

mitochondrial ribosomal protein L45

chrX_-_56598069 0.539 ENSMUST00000059899.2
 Mmgt1
membrane magnesium transporter 1
chr8_-_21906412 0.521 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr5_+_115341225 0.514 ENSMUST00000031508.4
 Triap1
TP53 regulated inhibitor of apoptosis 1
chr2_+_27079371 0.489 ENSMUST00000091233.6
 Adamtsl2
ADAMTS-like 2
chr5_-_5266038 0.387 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
 Cdk14


cyclin-dependent kinase 14


chr1_+_71652837 0.379 ENSMUST00000097699.2
 Apol7d
apolipoprotein L 7d
chrM_-_14060 0.343 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr19_-_32196393 0.338 ENSMUST00000151822.1
 Sgms1
sphingomyelin synthase 1
chr7_+_78783119 0.294 ENSMUST00000032840.4
 Mrps11
mitochondrial ribosomal protein S11
chr3_-_10331358 0.274 ENSMUST00000065938.8
ENSMUST00000118410.1
 Impa1

inositol (myo)-1(or 4)-monophosphatase 1

chr10_+_128083273 0.266 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr13_-_97747399 0.261 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr2_-_73580288 0.231 ENSMUST00000028515.3
 Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr1_-_4785671 0.201 ENSMUST00000130201.1
ENSMUST00000156816.1
 Mrpl15

mitochondrial ribosomal protein L15

chr4_-_129261394 0.197 ENSMUST00000145261.1
 C77080
expressed sequence C77080
chr3_-_89998656 0.165 ENSMUST00000079724.4
 Hax1
HCLS1 associated X-1
chr1_+_24005505 0.116 ENSMUST00000181961.1
 Gm26524
predicted gene, 26524
chr14_+_58893465 0.033 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.6 2.6 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.6 2.6 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.6 1.9 GO:0036292 DNA rewinding(GO:0036292)
0.6 4.6 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.4 1.3 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.4 2.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 1.9 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.4 1.1 GO:0006106 fumarate metabolic process(GO:0006106)
0.3 2.0 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.2 0.7 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.2 0.6 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.2 1.2 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.2 2.1 GO:0061032 chorio-allantoic fusion(GO:0060710) visceral serous pericardium development(GO:0061032)
0.2 1.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 4.6 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.7 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.9 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.1 2.7 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 0.7 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 1.7 GO:0080111 DNA demethylation(GO:0080111)
0.1 0.3 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 0.5 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.5 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.2 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.5 GO:0060481 lobar bronchus epithelium development(GO:0060481) lobar bronchus development(GO:0060482)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 2.5 GO:0051225 spindle assembly(GO:0051225)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.2 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.7 GO:0006400 tRNA modification(GO:0006400)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.3 1.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 2.5 GO:0070652 HAUS complex(GO:0070652)
0.3 2.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 2.1 GO:0002102 podosome(GO:0002102)
0.1 0.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 1.1 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 1.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.9 GO:0043596 nuclear replication fork(GO:0043596)
0.0 3.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.9 GO:0045120 pronucleus(GO:0045120)
0.0 0.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 6.2 GO:0030426 growth cone(GO:0030426)
0.0 2.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.3 GO:0070469 respiratory chain(GO:0070469)
0.0 5.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.6 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.5 2.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.4 2.6 GO:0000150 recombinase activity(GO:0000150)
0.3 1.9 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.3 1.2 GO:0008142 oxysterol binding(GO:0008142)
0.3 2.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 1.9 GO:0036310 annealing helicase activity(GO:0036310)
0.1 0.5 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.5 GO:0050436 microfibril binding(GO:0050436)
0.1 1.3 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.1 2.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 4.6 GO:0005109 frizzled binding(GO:0005109)
0.1 0.7 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 2.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.9 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 0.3 GO:0031403 lithium ion binding(GO:0031403)
0.1 0.5 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 0.7 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.1 0.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.5 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.1 0.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 1.7 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.6 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.1 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 6.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.1 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.7 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)