Motif ID: Gli1

Z-value: 0.447


Transcription factors associated with Gli1:

Gene SymbolEntrez IDGene Name
Gli1 ENSMUSG00000025407.6 Gli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli1mm10_v2_chr10_-_127341583_127341614-0.411.4e-03Click!


Activity profile for motif Gli1.

activity profile for motif Gli1


Sorted Z-values histogram for motif Gli1

Sorted Z-values for motif Gli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 162 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_42000284 3.409 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr8_+_54954728 3.332 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr11_-_42000532 2.559 ENSMUST00000070735.3
 Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr1_-_133801031 2.405 ENSMUST00000143567.1
 Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr17_+_37045963 2.259 ENSMUST00000025338.9
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr11_+_80300866 2.186 ENSMUST00000017836.7
 Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr1_+_152954966 2.173 ENSMUST00000043313.8
 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr18_-_43373248 2.099 ENSMUST00000118043.1
 Dpysl3
dihydropyrimidinase-like 3
chr11_-_119547744 2.072 ENSMUST00000026670.4
 Nptx1
neuronal pentraxin 1
chr15_-_78544345 2.018 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr2_-_29253001 2.005 ENSMUST00000071201.4
 Ntng2
netrin G2
chr1_-_56972437 1.934 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr4_-_148130678 1.900 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr18_+_37477768 1.874 ENSMUST00000051442.5
 Pcdhb16
protocadherin beta 16
chr8_+_45658666 1.861 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr10_+_69533761 1.833 ENSMUST00000182884.1
 Ank3
ankyrin 3, epithelial
chr2_+_106693185 1.784 ENSMUST00000111063.1
 Mpped2
metallophosphoesterase domain containing 2
chr15_-_100584075 1.766 ENSMUST00000184908.1
 POU6F1
POU domain, class 6, transcription factor 1 (Pou6f1), mRNA
chr8_+_45658731 1.718 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr10_+_69533803 1.674 ENSMUST00000182155.1
ENSMUST00000183169.1
ENSMUST00000183148.1
 Ank3


ankyrin 3, epithelial



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 6.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.6 5.8 GO:0071420 cellular response to histamine(GO:0071420)
0.1 5.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 3.6 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.1 3.3 GO:0003407 neural retina development(GO:0003407)
0.8 2.4 GO:0045763 negative regulation of cellular amino acid metabolic process(GO:0045763)
0.4 2.4 GO:1900451 rhythmic synaptic transmission(GO:0060024) terminal button organization(GO:0072553) positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of protein localization to synapse(GO:1902474) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.5 2.2 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.7 2.1 GO:0035864 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.1 2.1 GO:0051764 actin crosslink formation(GO:0051764)
0.1 2.1 GO:0007520 myoblast fusion(GO:0007520)
0.1 2.0 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 1.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 1.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.9 GO:0021516 dorsal spinal cord development(GO:0021516)
0.3 1.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 1.7 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.2 1.6 GO:0071361 autophagic cell death(GO:0048102) cellular response to ethanol(GO:0071361)
0.1 1.5 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.3 1.4 GO:0030242 pexophagy(GO:0030242)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 5.8 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 4.9 GO:0060076 excitatory synapse(GO:0060076)
0.1 4.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 3.9 GO:0060170 ciliary membrane(GO:0060170)
0.1 3.7 GO:0060077 inhibitory synapse(GO:0060077)
0.7 3.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 3.3 GO:0044295 axonal growth cone(GO:0044295)
0.1 2.4 GO:0097228 sperm principal piece(GO:0097228)
0.0 2.3 GO:0097060 synaptic membrane(GO:0097060)
0.0 2.1 GO:0031941 filamentous actin(GO:0031941)
0.0 2.1 GO:0005770 late endosome(GO:0005770)
0.1 2.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.6 1.7 GO:0097512 cardiac myofibril(GO:0097512)
0.0 1.2 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.1 GO:0043194 axon initial segment(GO:0043194)
0.0 1.1 GO:0030175 filopodium(GO:0030175)
0.1 1.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 1.0 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 5.8 GO:0004890 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.0 4.0 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.6 3.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 2.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 2.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.5 2.2 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.5 2.1 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.7 2.0 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 2.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.8 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.2 1.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 1.4 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.0 1.4 GO:0016209 antioxidant activity(GO:0016209)
0.0 1.3 GO:0005080 protein kinase C binding(GO:0005080)
0.2 1.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.2 1.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 1.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 1.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)