Motif ID: Gli2

Z-value: 0.514


Transcription factors associated with Gli2:

Gene SymbolEntrez IDGene Name
Gli2 ENSMUSG00000048402.8 Gli2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_119053619_1190536380.471.9e-04Click!


Activity profile for motif Gli2.

activity profile for motif Gli2


Sorted Z-values histogram for motif Gli2

Sorted Z-values for motif Gli2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli2

PNG image of the network

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Top targets:


Showing 1 to 20 of 142 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_72788952 1.988 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr6_-_72789240 1.986 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr9_+_13662460 1.723 ENSMUST00000177755.1
 Maml2
mastermind like 2 (Drosophila)
chrX_-_9662950 1.693 ENSMUST00000033519.2
 Dynlt3
dynein light chain Tctex-type 3
chrX_+_137049586 1.622 ENSMUST00000047852.7
 Fam199x
family with sequence similarity 199, X-linked
chr7_-_137314394 1.429 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr3_+_107036156 1.406 ENSMUST00000052718.3
 Kcna3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr3_+_127633134 1.247 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr1_+_55406163 1.243 ENSMUST00000042986.8
 Plcl1
phospholipase C-like 1
chr7_-_4752972 1.217 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr5_-_53213447 1.186 ENSMUST00000031090.6
 Sel1l3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr4_-_120287349 1.182 ENSMUST00000102656.3
 Foxo6
forkhead box O6
chr1_-_51915968 1.140 ENSMUST00000046390.7
 Myo1b
myosin IB
chr3_-_135608221 1.126 ENSMUST00000132668.1
 Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chr3_+_105452326 1.075 ENSMUST00000098761.3
 Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr1_-_51915901 1.052 ENSMUST00000018561.7
ENSMUST00000114537.2
 Myo1b

myosin IB

chr7_-_116308241 1.050 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr16_+_19760902 0.971 ENSMUST00000119468.1
 B3gnt5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr8_+_127063893 0.961 ENSMUST00000162309.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr8_+_127064022 0.931 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 4.0 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.4 2.6 GO:0003383 apical constriction(GO:0003383)
0.0 2.2 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.2 1.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.2 1.7 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.2 1.6 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.1 1.4 GO:0071435 potassium ion export(GO:0071435)
0.0 1.3 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.2 1.2 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 1.2 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.3 1.1 GO:1903416 negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) regulation of calcidiol 1-monooxygenase activity(GO:0060558) response to glycoside(GO:1903416)
0.2 1.0 GO:0015705 iodide transport(GO:0015705)
0.2 1.0 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 1.0 GO:0090527 actin filament reorganization(GO:0090527)
0.0 1.0 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.0 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.0 0.9 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.3 0.8 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.3 0.8 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.0 0.8 GO:0007638 mechanosensory behavior(GO:0007638)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.6 GO:0033269 internode region of axon(GO:0033269)
0.1 2.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.9 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 1.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.7 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.3 GO:0097470 ribbon synapse(GO:0097470)
0.1 1.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 1.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 1.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.0 GO:0005915 zonula adherens(GO:0005915)
0.2 0.7 GO:0090537 CERF complex(GO:0090537)
0.2 0.7 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.7 GO:0071203 WASH complex(GO:0071203)
0.1 0.5 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.4 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.4 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0008013 beta-catenin binding(GO:0008013)
0.1 2.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 2.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.6 1.7 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 1.6 GO:0003774 motor activity(GO:0003774)
0.2 1.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 1.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 1.3 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.1 1.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.2 GO:0070888 E-box binding(GO:0070888)
0.2 1.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 1.1 GO:0042805 actinin binding(GO:0042805)
0.0 1.1 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.3 1.0 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.2 1.0 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.3 0.9 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.8 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 0.7 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)