Motif ID: Gli3_Zic1

Z-value: 1.525

Transcription factors associated with Gli3_Zic1:

Gene SymbolEntrez IDGene Name
Gli3 ENSMUSG00000021318.9 Gli3
Zic1 ENSMUSG00000032368.8 Zic1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli3mm10_v2_chr13_+_15463837_15463980-0.606.5e-07Click!
Zic1mm10_v2_chr9_-_91365756_91365774-0.229.0e-02Click!


Activity profile for motif Gli3_Zic1.

activity profile for motif Gli3_Zic1


Sorted Z-values histogram for motif Gli3_Zic1

Sorted Z-values for motif Gli3_Zic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli3_Zic1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 17.881 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr9_+_50752758 14.540 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr4_-_148130678 11.424 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr10_-_127341583 9.884 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr6_-_101377897 9.729 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr8_-_105966038 9.122 ENSMUST00000116429.2
ENSMUST00000034370.9
 Slc12a4

solute carrier family 12, member 4

chr2_-_29253001 8.916 ENSMUST00000071201.4
 Ntng2
netrin G2
chr6_-_101377342 8.878 ENSMUST00000151175.1
 Pdzrn3
PDZ domain containing RING finger 3
chr7_-_100656953 8.734 ENSMUST00000107046.1
ENSMUST00000107045.1
ENSMUST00000139708.1
 Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr8_+_70501116 8.699 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chrX_-_16911774 8.522 ENSMUST00000040134.7
 Ndp
Norrie disease (pseudoglioma) (human)
chr4_-_68954351 7.693 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr1_-_133801031 7.072 ENSMUST00000143567.1
 Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr4_+_124657646 6.959 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr9_-_54661666 6.830 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr9_-_54661870 6.779 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr18_-_38601268 6.708 ENSMUST00000025295.6
 Spry4
sprouty homolog 4 (Drosophila)
chr16_-_28445227 6.656 ENSMUST00000100024.1
 Fgf12
fibroblast growth factor 12
chr6_+_86195214 6.636 ENSMUST00000032066.9
 Tgfa
transforming growth factor alpha
chr7_-_19698383 6.402 ENSMUST00000173739.1
 Apoe
apolipoprotein E

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.2 GO:0048663 neuron fate commitment(GO:0048663)
0.4 18.6 GO:0007528 neuromuscular junction development(GO:0007528)
1.8 16.5 GO:0071420 cellular response to histamine(GO:0071420)
0.4 14.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
2.4 14.5 GO:0007021 tubulin complex assembly(GO:0007021)
2.1 12.4 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.6 11.4 GO:0021516 dorsal spinal cord development(GO:0021516)
2.5 9.9 GO:0060032 notochord regression(GO:0060032)
0.9 9.8 GO:0071635 negative regulation of transforming growth factor beta production(GO:0071635)
3.1 9.3 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.1 9.3 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.8 9.0 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
1.7 8.5 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
1.2 8.5 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
1.4 8.4 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.2 8.4 GO:2001258 negative regulation of cation channel activity(GO:2001258)
0.8 8.3 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.7 8.0 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.6 7.7 GO:0042711 maternal behavior(GO:0042711)
0.7 7.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 28.5 GO:0060077 inhibitory synapse(GO:0060077)
0.1 20.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 20.2 GO:0005667 transcription factor complex(GO:0005667)
0.2 19.2 GO:0031594 neuromuscular junction(GO:0031594)
0.1 17.4 GO:0005925 focal adhesion(GO:0005925)
0.1 14.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.5 14.3 GO:0030673 axolemma(GO:0030673)
4.7 14.2 GO:0097512 cardiac myofibril(GO:0097512)
0.1 12.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 11.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.3 10.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.8 9.9 GO:0097542 ciliary tip(GO:0097542)
0.3 8.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
2.9 8.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
1.7 8.5 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.7 7.6 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 7.3 GO:0009925 basal plasma membrane(GO:0009925)
0.4 7.1 GO:0097228 sperm principal piece(GO:0097228)
0.7 6.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
2.1 6.4 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 16.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 15.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.2 13.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 13.6 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.0 13.3 GO:0046983 protein dimerization activity(GO:0046983)
0.7 12.1 GO:0042043 neurexin family protein binding(GO:0042043)
1.3 11.5 GO:0005212 structural constituent of eye lens(GO:0005212)
1.5 9.1 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
1.3 9.0 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
1.2 8.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.4 8.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
1.4 8.5 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.5 8.2 GO:0015026 coreceptor activity(GO:0015026)
2.0 8.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 8.1 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.6 8.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.8 7.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 7.5 GO:0005516 calmodulin binding(GO:0005516)
1.1 6.8 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.2 6.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)