Motif ID: Gli3_Zic1
Z-value: 1.525
Transcription factors associated with Gli3_Zic1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Gli3 | ENSMUSG00000021318.9 | Gli3 |
Zic1 | ENSMUSG00000032368.8 | Zic1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Gli3 | mm10_v2_chr13_+_15463837_15463980 | -0.60 | 6.5e-07 | Click! |
Zic1 | mm10_v2_chr9_-_91365756_91365774 | -0.22 | 9.0e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.1 | 9.3 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) |
2.5 | 9.9 | GO:0060032 | notochord regression(GO:0060032) |
2.4 | 14.5 | GO:0007021 | tubulin complex assembly(GO:0007021) |
2.4 | 7.1 | GO:0045763 | regulation of arginine metabolic process(GO:0000821) negative regulation of cellular amino acid metabolic process(GO:0045763) |
2.1 | 6.4 | GO:2001139 | negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139) |
2.1 | 12.4 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
1.9 | 5.6 | GO:1903903 | striated muscle atrophy(GO:0014891) positive regulation of keratinocyte apoptotic process(GO:1902174) regulation of establishment of T cell polarity(GO:1903903) |
1.8 | 16.5 | GO:0071420 | cellular response to histamine(GO:0071420) |
1.8 | 7.1 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
1.8 | 5.3 | GO:1904685 | positive regulation of metalloendopeptidase activity(GO:1904685) |
1.7 | 8.5 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
1.4 | 4.3 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
1.4 | 8.4 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
1.4 | 5.5 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
1.2 | 8.5 | GO:0032811 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811) |
1.2 | 5.9 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
1.0 | 3.1 | GO:0006558 | L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) |
1.0 | 3.0 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980) |
1.0 | 4.8 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
0.9 | 2.8 | GO:1902460 | regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) |
0.9 | 6.3 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
0.9 | 9.8 | GO:0071635 | negative regulation of transforming growth factor beta production(GO:0071635) |
0.9 | 2.6 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
0.8 | 3.4 | GO:2000823 | regulation of androgen receptor activity(GO:2000823) |
0.8 | 5.9 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
0.8 | 2.4 | GO:0043696 | dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) |
0.8 | 3.9 | GO:0001661 | conditioned taste aversion(GO:0001661) |
0.8 | 8.3 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
0.8 | 0.8 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
0.8 | 9.0 | GO:1902993 | positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993) |
0.7 | 2.9 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
0.7 | 7.2 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
0.7 | 2.1 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
0.7 | 4.8 | GO:0021940 | positive regulation of cerebellar granule cell precursor proliferation(GO:0021940) |
0.7 | 4.1 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
0.7 | 8.0 | GO:2000465 | regulation of glycogen (starch) synthase activity(GO:2000465) |
0.7 | 6.6 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
0.6 | 7.7 | GO:0042711 | maternal behavior(GO:0042711) |
0.6 | 1.9 | GO:0006533 | aspartate catabolic process(GO:0006533) D-amino acid catabolic process(GO:0019478) |
0.6 | 2.5 | GO:0086045 | smooth muscle contraction involved in micturition(GO:0060083) membrane depolarization during AV node cell action potential(GO:0086045) membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) |
0.6 | 2.4 | GO:1903587 | regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) |
0.6 | 2.4 | GO:0097167 | circadian regulation of translation(GO:0097167) |
0.6 | 11.4 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
0.6 | 3.5 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
0.6 | 2.3 | GO:0007262 | STAT protein import into nucleus(GO:0007262) |
0.6 | 1.7 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
0.6 | 0.6 | GO:0060681 | branch elongation involved in ureteric bud branching(GO:0060681) |
0.6 | 3.5 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
0.6 | 3.4 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
0.5 | 4.9 | GO:0036465 | synaptic vesicle recycling(GO:0036465) |
0.5 | 3.2 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
0.5 | 2.7 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
0.5 | 1.6 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
0.5 | 3.0 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.5 | 2.5 | GO:0015671 | oxygen transport(GO:0015671) |
0.5 | 1.9 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
0.5 | 1.4 | GO:0070589 | cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506) cell wall biogenesis(GO:0042546) cell wall macromolecule metabolic process(GO:0044036) cell wall macromolecule biosynthetic process(GO:0044038) chain elongation of O-linked mannose residue(GO:0044845) cellular component macromolecule biosynthetic process(GO:0070589) cell wall organization or biogenesis(GO:0071554) |
0.5 | 1.9 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
0.5 | 2.8 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
0.5 | 2.3 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
0.5 | 2.3 | GO:0007256 | activation of JNKK activity(GO:0007256) |
0.4 | 3.6 | GO:0036506 | maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
0.4 | 4.0 | GO:0071435 | potassium ion export(GO:0071435) |
0.4 | 1.6 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
0.4 | 6.6 | GO:0001553 | luteinization(GO:0001553) |
0.4 | 18.6 | GO:0007528 | neuromuscular junction development(GO:0007528) |
0.4 | 4.4 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.4 | 14.6 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
0.4 | 3.0 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
0.4 | 1.4 | GO:2000812 | regulation of barbed-end actin filament capping(GO:2000812) |
0.3 | 1.0 | GO:1903722 | regulation of centriole elongation(GO:1903722) |
0.3 | 1.7 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
0.3 | 2.3 | GO:2000807 | regulation of synaptic vesicle clustering(GO:2000807) |
0.3 | 1.6 | GO:0030259 | lipid glycosylation(GO:0030259) |
0.3 | 5.1 | GO:0031958 | corticosteroid receptor signaling pathway(GO:0031958) |
0.3 | 0.3 | GO:0048023 | positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378) |
0.3 | 0.9 | GO:1902358 | sulfate transmembrane transport(GO:1902358) |
0.3 | 2.1 | GO:0015840 | urea transport(GO:0015840) urea transmembrane transport(GO:0071918) |
0.3 | 0.9 | GO:1904742 | protein poly-ADP-ribosylation(GO:0070212) regulation of telomeric DNA binding(GO:1904742) |
0.3 | 20.2 | GO:0048663 | neuron fate commitment(GO:0048663) |
0.3 | 1.6 | GO:0060872 | semicircular canal morphogenesis(GO:0048752) semicircular canal development(GO:0060872) |
0.3 | 2.8 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
0.3 | 1.8 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
0.3 | 2.3 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
0.2 | 1.7 | GO:0000050 | urea cycle(GO:0000050) urea metabolic process(GO:0019627) cellular response to lithium ion(GO:0071285) |
0.2 | 0.5 | GO:0010512 | negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) |
0.2 | 1.0 | GO:0055071 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071) |
0.2 | 1.0 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
0.2 | 1.4 | GO:0021636 | trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) |
0.2 | 6.5 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
0.2 | 8.4 | GO:2001258 | negative regulation of cation channel activity(GO:2001258) |
0.2 | 2.0 | GO:0097119 | postsynaptic density protein 95 clustering(GO:0097119) |
0.2 | 1.4 | GO:0036233 | glycine import(GO:0036233) |
0.2 | 1.1 | GO:0061687 | detoxification of inorganic compound(GO:0061687) |
0.2 | 0.8 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
0.2 | 5.4 | GO:2000463 | positive regulation of excitatory postsynaptic potential(GO:2000463) |
0.2 | 1.3 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
0.2 | 2.2 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
0.2 | 0.4 | GO:0003032 | detection of oxygen(GO:0003032) |
0.2 | 1.4 | GO:0019348 | dolichol metabolic process(GO:0019348) |
0.2 | 0.7 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
0.2 | 1.2 | GO:0099625 | regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) ventricular cardiac muscle cell membrane repolarization(GO:0099625) |
0.2 | 1.0 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
0.2 | 0.3 | GO:2001025 | positive regulation of response to drug(GO:2001025) |
0.2 | 0.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.1 | 1.3 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
0.1 | 0.4 | GO:0021523 | somatic motor neuron differentiation(GO:0021523) |
0.1 | 1.0 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
0.1 | 0.9 | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) |
0.1 | 9.3 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
0.1 | 0.7 | GO:0048597 | post-embryonic camera-type eye morphogenesis(GO:0048597) |
0.1 | 0.7 | GO:0090164 | asymmetric Golgi ribbon formation(GO:0090164) |
0.1 | 1.4 | GO:0051601 | exocyst localization(GO:0051601) |
0.1 | 0.8 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
0.1 | 0.4 | GO:1900275 | negative regulation of phospholipase C activity(GO:1900275) regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736) |
0.1 | 5.4 | GO:0032418 | lysosome localization(GO:0032418) |
0.1 | 2.3 | GO:0035094 | response to nicotine(GO:0035094) |
0.1 | 2.8 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.1 | 0.3 | GO:0070375 | ERK5 cascade(GO:0070375) |
0.1 | 0.6 | GO:0051697 | protein delipidation(GO:0051697) |
0.1 | 0.4 | GO:0019042 | viral latency(GO:0019042) |
0.1 | 1.7 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
0.1 | 0.6 | GO:0043615 | astrocyte cell migration(GO:0043615) |
0.1 | 0.8 | GO:0061088 | sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088) |
0.1 | 3.7 | GO:0007520 | myoblast fusion(GO:0007520) |
0.1 | 0.7 | GO:0006498 | N-terminal protein lipidation(GO:0006498) |
0.1 | 1.3 | GO:0048305 | immunoglobulin secretion(GO:0048305) |
0.1 | 3.1 | GO:0090004 | positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
0.1 | 5.2 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
0.1 | 0.2 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
0.1 | 0.7 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
0.1 | 6.4 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
0.1 | 0.9 | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012) |
0.1 | 1.4 | GO:0070207 | protein homotrimerization(GO:0070207) |
0.1 | 0.3 | GO:0035864 | response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865) axonogenesis involved in innervation(GO:0060385) |
0.1 | 2.0 | GO:0033198 | response to ATP(GO:0033198) |
0.1 | 1.5 | GO:0090083 | regulation of inclusion body assembly(GO:0090083) |
0.1 | 1.4 | GO:0051898 | negative regulation of protein kinase B signaling(GO:0051898) |
0.1 | 1.3 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
0.1 | 5.2 | GO:0043407 | negative regulation of MAP kinase activity(GO:0043407) |
0.1 | 3.5 | GO:0031529 | ruffle organization(GO:0031529) |
0.1 | 0.2 | GO:0003256 | regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003256) atrioventricular canal development(GO:0036302) |
0.1 | 0.9 | GO:2001197 | regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197) |
0.1 | 1.5 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
0.1 | 1.6 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
0.1 | 0.9 | GO:0060384 | innervation(GO:0060384) |
0.1 | 1.2 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
0.1 | 0.2 | GO:0045950 | telomeric loop formation(GO:0031627) negative regulation of mitotic recombination(GO:0045950) negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
0.1 | 0.8 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
0.1 | 2.3 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.1 | 1.4 | GO:0070266 | necroptotic process(GO:0070266) |
0.1 | 0.4 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
0.1 | 1.8 | GO:0035418 | protein localization to synapse(GO:0035418) |
0.1 | 0.2 | GO:0070124 | mitochondrial translational initiation(GO:0070124) |
0.1 | 2.9 | GO:0045839 | negative regulation of mitotic nuclear division(GO:0045839) |
0.1 | 3.9 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
0.1 | 2.5 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
0.1 | 0.7 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
0.1 | 0.4 | GO:0044539 | long-chain fatty acid import(GO:0044539) |
0.1 | 2.0 | GO:0021799 | cerebral cortex radially oriented cell migration(GO:0021799) |
0.1 | 0.3 | GO:0015074 | DNA integration(GO:0015074) |
0.1 | 2.6 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
0.1 | 7.2 | GO:0006813 | potassium ion transport(GO:0006813) |
0.1 | 0.3 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
0.0 | 1.8 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
0.0 | 2.1 | GO:0050729 | positive regulation of inflammatory response(GO:0050729) |
0.0 | 0.5 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) regulation of histone H3-K9 trimethylation(GO:1900112) negative regulation of histone H3-K9 trimethylation(GO:1900113) |
0.0 | 0.4 | GO:0070914 | UV-damage excision repair(GO:0070914) |
0.0 | 1.0 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
0.0 | 0.5 | GO:0007289 | spermatid nucleus differentiation(GO:0007289) |
0.0 | 1.1 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
0.0 | 0.2 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
0.0 | 0.4 | GO:0006828 | manganese ion transport(GO:0006828) |
0.0 | 0.2 | GO:0010919 | regulation of inositol phosphate biosynthetic process(GO:0010919) positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
0.0 | 0.3 | GO:0042407 | cristae formation(GO:0042407) |
0.0 | 1.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.1 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
0.0 | 0.1 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
0.0 | 0.1 | GO:0006361 | transcription initiation from RNA polymerase I promoter(GO:0006361) |
0.0 | 0.5 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
0.0 | 1.1 | GO:0035383 | acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383) |
0.0 | 0.1 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
0.0 | 0.3 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
0.0 | 0.6 | GO:0048286 | lung alveolus development(GO:0048286) |
0.0 | 0.4 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.7 | 14.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
2.9 | 8.7 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
2.1 | 6.4 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
1.7 | 8.5 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
1.0 | 3.9 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
0.9 | 28.5 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.8 | 9.9 | GO:0097542 | ciliary tip(GO:0097542) |
0.7 | 7.6 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
0.7 | 6.8 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
0.6 | 1.7 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
0.5 | 4.9 | GO:0030478 | actin cap(GO:0030478) |
0.5 | 3.6 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
0.5 | 14.3 | GO:0030673 | axolemma(GO:0030673) |
0.5 | 5.5 | GO:0072546 | ER membrane protein complex(GO:0072546) |
0.4 | 5.3 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
0.4 | 7.1 | GO:0097228 | sperm principal piece(GO:0097228) |
0.3 | 1.4 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
0.3 | 1.0 | GO:0097447 | dendritic tree(GO:0097447) |
0.3 | 1.7 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
0.3 | 10.4 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
0.3 | 1.4 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
0.3 | 8.9 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
0.2 | 3.5 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
0.2 | 19.2 | GO:0031594 | neuromuscular junction(GO:0031594) |
0.2 | 3.5 | GO:0031143 | pseudopodium(GO:0031143) |
0.2 | 1.2 | GO:0044294 | dendritic growth cone(GO:0044294) |
0.2 | 0.4 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
0.2 | 1.8 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
0.2 | 0.4 | GO:0033648 | host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648) |
0.2 | 2.3 | GO:0005922 | connexon complex(GO:0005922) |
0.2 | 3.0 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
0.2 | 0.6 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) |
0.2 | 0.8 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.1 | 4.0 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.1 | 7.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
0.1 | 1.4 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
0.1 | 2.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
0.1 | 0.7 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
0.1 | 1.0 | GO:0072687 | meiotic spindle(GO:0072687) |
0.1 | 2.1 | GO:0097386 | glial cell projection(GO:0097386) |
0.1 | 1.0 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
0.1 | 1.0 | GO:0000815 | ESCRT III complex(GO:0000815) |
0.1 | 3.0 | GO:0032589 | neuron projection membrane(GO:0032589) |
0.1 | 5.6 | GO:0005905 | clathrin-coated pit(GO:0005905) |
0.1 | 2.6 | GO:0045178 | basal part of cell(GO:0045178) |
0.1 | 0.6 | GO:0000322 | storage vacuole(GO:0000322) |
0.1 | 20.8 | GO:0045211 | postsynaptic membrane(GO:0045211) |
0.1 | 3.5 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
0.1 | 1.7 | GO:0030139 | endocytic vesicle(GO:0030139) |
0.1 | 4.4 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
0.1 | 1.4 | GO:0000145 | exocyst(GO:0000145) |
0.1 | 1.0 | GO:0043194 | axon initial segment(GO:0043194) |
0.1 | 5.3 | GO:0030175 | filopodium(GO:0030175) |
0.1 | 14.5 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
0.1 | 0.3 | GO:0032585 | multivesicular body membrane(GO:0032585) |
0.1 | 1.1 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
0.1 | 2.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
0.1 | 11.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.1 | 3.7 | GO:0005798 | Golgi-associated vesicle(GO:0005798) |
0.1 | 12.7 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
0.1 | 1.9 | GO:0031941 | filamentous actin(GO:0031941) |
0.1 | 17.4 | GO:0005925 | focal adhesion(GO:0005925) |
0.0 | 0.4 | GO:0070688 | MLL5-L complex(GO:0070688) |
0.0 | 0.4 | GO:0031902 | late endosome membrane(GO:0031902) |
0.0 | 1.0 | GO:0030315 | T-tubule(GO:0030315) |
0.0 | 0.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 20.2 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 3.4 | GO:0043204 | perikaryon(GO:0043204) |
0.0 | 1.4 | GO:0035869 | ciliary transition zone(GO:0035869) |
0.0 | 4.0 | GO:0030017 | sarcomere(GO:0030017) |
0.0 | 1.5 | GO:0097060 | synaptic membrane(GO:0097060) |
0.0 | 1.4 | GO:0045171 | intercellular bridge(GO:0045171) |
0.0 | 0.2 | GO:0030870 | Mre11 complex(GO:0030870) |
0.0 | 4.8 | GO:0043235 | receptor complex(GO:0043235) |
0.0 | 0.2 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
0.0 | 1.4 | GO:0032587 | ruffle membrane(GO:0032587) |
0.0 | 0.3 | GO:0061617 | MICOS complex(GO:0061617) |
0.0 | 1.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.7 | GO:0016459 | myosin complex(GO:0016459) |
0.0 | 0.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
0.0 | 1.9 | GO:0055037 | recycling endosome(GO:0055037) |
0.0 | 0.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
0.0 | 0.2 | GO:0030057 | desmosome(GO:0030057) |
0.0 | 0.5 | GO:0005902 | microvillus(GO:0005902) |
0.0 | 1.2 | GO:0005770 | late endosome(GO:0005770) |
0.0 | 0.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.0 | 0.3 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
0.0 | 0.3 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
0.0 | 0.9 | GO:0005643 | nuclear pore(GO:0005643) |
0.0 | 0.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
0.0 | 1.5 | GO:0030141 | secretory granule(GO:0030141) |
0.0 | 0.3 | GO:0098797 | plasma membrane protein complex(GO:0098797) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.1 | 6.4 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
2.0 | 8.1 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
1.5 | 9.1 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
1.4 | 8.5 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
1.3 | 3.9 | GO:0070905 | serine binding(GO:0070905) |
1.3 | 9.0 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
1.3 | 11.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
1.2 | 8.7 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
1.2 | 13.6 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
1.2 | 4.8 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
1.2 | 3.5 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
1.1 | 6.8 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
1.1 | 3.4 | GO:0035939 | microsatellite binding(GO:0035939) |
1.1 | 3.4 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
0.9 | 16.5 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
0.9 | 3.5 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.8 | 3.4 | GO:2001069 | glycogen binding(GO:2001069) |
0.8 | 7.6 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
0.8 | 4.1 | GO:0038132 | neuregulin binding(GO:0038132) |
0.8 | 4.0 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.8 | 5.5 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
0.7 | 5.9 | GO:0048495 | Roundabout binding(GO:0048495) |
0.7 | 12.1 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.6 | 4.4 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
0.6 | 1.9 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) hedgehog family protein binding(GO:0097108) |
0.6 | 2.5 | GO:0004096 | catalase activity(GO:0004096) |
0.6 | 8.0 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
0.6 | 5.3 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
0.5 | 2.7 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
0.5 | 1.6 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
0.5 | 2.6 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
0.5 | 3.0 | GO:0005042 | netrin receptor activity(GO:0005042) |
0.5 | 1.9 | GO:0003884 | D-amino-acid oxidase activity(GO:0003884) aspartate oxidase activity(GO:0015922) |
0.5 | 1.9 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
0.5 | 1.8 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
0.5 | 1.4 | GO:0032052 | bile acid binding(GO:0032052) |
0.5 | 8.2 | GO:0015026 | coreceptor activity(GO:0015026) |
0.5 | 5.9 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.4 | 1.8 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
0.4 | 2.6 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
0.4 | 3.0 | GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) |
0.4 | 2.0 | GO:0045545 | syndecan binding(GO:0045545) |
0.4 | 8.7 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.4 | 2.8 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
0.3 | 2.1 | GO:0015265 | urea channel activity(GO:0015265) |
0.3 | 2.0 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
0.3 | 1.0 | GO:0001888 | glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888) |
0.3 | 2.3 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
0.3 | 2.3 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
0.3 | 1.4 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
0.3 | 1.0 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
0.2 | 3.8 | GO:0001223 | transcription coactivator binding(GO:0001223) |
0.2 | 0.9 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
0.2 | 1.4 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
0.2 | 0.8 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
0.2 | 2.3 | GO:0005243 | gap junction channel activity(GO:0005243) |
0.2 | 4.6 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
0.2 | 3.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.2 | 6.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
0.2 | 1.0 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
0.2 | 1.7 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.2 | 3.6 | GO:0070628 | proteasome binding(GO:0070628) |
0.2 | 3.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.2 | 0.5 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
0.2 | 0.7 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
0.2 | 5.0 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.1 | 0.7 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
0.1 | 3.5 | GO:0003785 | actin monomer binding(GO:0003785) |
0.1 | 3.1 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
0.1 | 2.4 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
0.1 | 0.7 | GO:0004724 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) |
0.1 | 1.5 | GO:0048038 | quinone binding(GO:0048038) |
0.1 | 1.4 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
0.1 | 1.3 | GO:0044548 | S100 protein binding(GO:0044548) |
0.1 | 15.7 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
0.1 | 0.4 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
0.1 | 3.8 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
0.1 | 1.2 | GO:1990715 | mRNA CDS binding(GO:1990715) |
0.1 | 0.6 | GO:0051425 | PTB domain binding(GO:0051425) |
0.1 | 4.3 | GO:0070888 | E-box binding(GO:0070888) |
0.1 | 3.1 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.1 | 1.0 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
0.1 | 2.0 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.1 | 1.4 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.1 | 1.3 | GO:0005522 | profilin binding(GO:0005522) |
0.1 | 4.1 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
0.1 | 5.7 | GO:0030276 | clathrin binding(GO:0030276) |
0.1 | 1.0 | GO:0102338 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
0.1 | 1.7 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
0.1 | 2.8 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
0.1 | 1.0 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
0.1 | 1.1 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.1 | 1.2 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
0.1 | 8.1 | GO:0019210 | protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210) |
0.1 | 0.9 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
0.1 | 0.6 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
0.1 | 0.9 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
0.1 | 3.5 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
0.1 | 1.7 | GO:0008327 | methyl-CpG binding(GO:0008327) |
0.1 | 5.4 | GO:0005262 | calcium channel activity(GO:0005262) |
0.1 | 6.3 | GO:0005125 | cytokine activity(GO:0005125) |
0.1 | 2.2 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.1 | 0.3 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
0.1 | 1.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
0.1 | 0.5 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
0.1 | 1.1 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
0.1 | 2.5 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
0.1 | 0.7 | GO:0001222 | transcription corepressor binding(GO:0001222) |
0.1 | 2.3 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
0.1 | 4.6 | GO:0008201 | heparin binding(GO:0008201) |
0.0 | 0.5 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
0.0 | 2.3 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
0.0 | 2.7 | GO:0017022 | myosin binding(GO:0017022) |
0.0 | 5.7 | GO:0044325 | ion channel binding(GO:0044325) |
0.0 | 13.6 | GO:0043774 | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738) |
0.0 | 7.5 | GO:0005516 | calmodulin binding(GO:0005516) |
0.0 | 4.7 | GO:0008565 | protein transporter activity(GO:0008565) |
0.0 | 3.5 | GO:0005178 | integrin binding(GO:0005178) |
0.0 | 0.1 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
0.0 | 4.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 0.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.6 | GO:0017160 | Ral GTPase binding(GO:0017160) |
0.0 | 0.3 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
0.0 | 0.7 | GO:0005112 | Notch binding(GO:0005112) retinoid X receptor binding(GO:0046965) |
0.0 | 0.4 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
0.0 | 1.6 | GO:0035064 | methylated histone binding(GO:0035064) |
0.0 | 0.3 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
0.0 | 1.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
0.0 | 0.2 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
0.0 | 0.1 | GO:0003945 | N-acetyllactosamine synthase activity(GO:0003945) |
0.0 | 0.1 | GO:0004303 | estradiol 17-beta-dehydrogenase activity(GO:0004303) |
0.0 | 0.3 | GO:0008143 | poly(A) binding(GO:0008143) |
0.0 | 0.2 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
0.0 | 3.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.0 | 1.0 | GO:0019894 | kinesin binding(GO:0019894) |
0.0 | 1.2 | GO:0000149 | SNARE binding(GO:0000149) |
0.0 | 2.5 | GO:0008022 | protein C-terminus binding(GO:0008022) |
0.0 | 1.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
0.0 | 13.3 | GO:0046983 | protein dimerization activity(GO:0046983) |
0.0 | 0.9 | GO:0051082 | unfolded protein binding(GO:0051082) |
0.0 | 0.3 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
0.0 | 0.2 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |