Motif ID: Glis2

Z-value: 0.973


Transcription factors associated with Glis2:

Gene SymbolEntrez IDGene Name
Glis2 ENSMUSG00000014303.7 Glis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis2mm10_v2_chr16_+_4594683_45947350.075.9e-01Click!


Activity profile for motif Glis2.

activity profile for motif Glis2


Sorted Z-values histogram for motif Glis2

Sorted Z-values for motif Glis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 192 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 13.532 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr3_-_66981279 7.146 ENSMUST00000162098.2
 Shox2
short stature homeobox 2
chr7_-_103843154 7.023 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr8_-_91801547 5.600 ENSMUST00000093312.4
 Irx3
Iroquois related homeobox 3 (Drosophila)
chr8_-_91801948 5.064 ENSMUST00000175795.1
 Irx3
Iroquois related homeobox 3 (Drosophila)
chr19_+_7268296 5.038 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr8_+_3631109 4.918 ENSMUST00000004745.8
 Stxbp2
syntaxin binding protein 2
chr5_+_136083916 4.600 ENSMUST00000042135.7
 Rasa4
RAS p21 protein activator 4
chr5_+_136084022 4.268 ENSMUST00000100570.3
 Rasa4
RAS p21 protein activator 4
chr7_-_126704736 4.162 ENSMUST00000131415.1
 Coro1a
coronin, actin binding protein 1A
chr2_-_54085542 4.138 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr8_-_87472576 3.929 ENSMUST00000034076.8
 Cbln1
cerebellin 1 precursor protein
chr3_-_89322883 3.889 ENSMUST00000029673.5
 Efna3
ephrin A3
chr19_+_55741810 3.776 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr4_+_115059507 3.741 ENSMUST00000162489.1
 Tal1
T cell acute lymphocytic leukemia 1
chr1_-_172329261 3.428 ENSMUST00000062387.2
 Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr2_-_57113053 3.356 ENSMUST00000112627.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr2_-_57124003 3.355 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr11_+_101468164 3.062 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr7_-_126704816 3.033 ENSMUST00000032949.7
 Coro1a
coronin, actin binding protein 1A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 16.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
1.2 11.6 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 10.6 GO:0007498 mesoderm development(GO:0007498)
0.2 8.9 GO:0034260 negative regulation of GTPase activity(GO:0034260)
1.2 7.2 GO:0032796 uropod organization(GO:0032796)
1.4 7.0 GO:0015671 oxygen transport(GO:0015671)
1.7 6.7 GO:0051866 general adaptation syndrome(GO:0051866)
0.8 5.4 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.2 4.9 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.3 3.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 3.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 3.9 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 3.9 GO:0007050 cell cycle arrest(GO:0007050)
0.5 3.8 GO:0048625 myoblast fate commitment(GO:0048625)
1.2 3.7 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.4 3.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.8 3.3 GO:0046898 response to cycloheximide(GO:0046898)
0.1 3.2 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.2 2.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 2.9 GO:0010107 potassium ion import(GO:0010107)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.3 7.2 GO:0001891 phagocytic cup(GO:0001891)
0.1 7.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.9 7.0 GO:0005833 hemoglobin complex(GO:0005833)
1.0 6.9 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 5.3 GO:0016235 aggresome(GO:0016235)
0.1 5.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 5.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
1.6 4.9 GO:0044194 cytolytic granule(GO:0044194)
0.0 4.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 3.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
1.2 3.7 GO:0033193 Lsd1/2 complex(GO:0033193)
0.3 3.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 3.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 3.3 GO:0005769 early endosome(GO:0005769)
0.0 2.7 GO:0005882 intermediate filament(GO:0005882)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.4 GO:0001726 ruffle(GO:0001726)
0.2 2.0 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 1.9 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 13.5 GO:0019841 retinol binding(GO:0019841)
0.3 7.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.7 7.2 GO:0032036 myosin heavy chain binding(GO:0032036)
1.8 7.0 GO:0031721 hemoglobin alpha binding(GO:0031721)
1.0 6.9 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 6.9 GO:0005096 GTPase activator activity(GO:0005096)
0.2 4.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 4.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 3.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 3.8 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 3.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.6 3.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 3.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.4 3.3 GO:0051434 BH3 domain binding(GO:0051434)
0.1 3.2 GO:0070888 E-box binding(GO:0070888)
0.0 3.1 GO:0047485 protein N-terminus binding(GO:0047485)
0.2 3.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 2.9 GO:0042165 neurotransmitter binding(GO:0042165)
0.3 2.7 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.9 2.6 GO:0010698 acetyltransferase activator activity(GO:0010698)