Motif ID: Glis3

Z-value: 0.596


Transcription factors associated with Glis3:

Gene SymbolEntrez IDGene Name
Glis3 ENSMUSG00000052942.7 Glis3
Glis3 ENSMUSG00000091294.1 Glis3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis3mm10_v2_chr19_-_28680077_28680122-0.085.6e-01Click!


Activity profile for motif Glis3.

activity profile for motif Glis3


Sorted Z-values histogram for motif Glis3

Sorted Z-values for motif Glis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 119 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_134018829 10.795 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr7_-_49636847 7.012 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr3_+_107595031 5.772 ENSMUST00000014747.1
 Alx3
aristaless-like homeobox 3
chr3_-_66981279 5.726 ENSMUST00000162098.2
 Shox2
short stature homeobox 2
chr7_-_142899985 5.671 ENSMUST00000000219.3
 Th
tyrosine hydroxylase
chr8_-_87959560 5.415 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr12_+_109743787 5.355 ENSMUST00000183068.1
 Mirg
miRNA containing gene
chr5_-_24527276 4.394 ENSMUST00000088311.4
 Gbx1
gastrulation brain homeobox 1
chr17_-_70851189 4.273 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr9_-_48835932 3.576 ENSMUST00000093852.3
 Zbtb16
zinc finger and BTB domain containing 16
chr7_-_142657466 3.462 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr13_-_40730416 3.274 ENSMUST00000021787.5
 Tfap2a
transcription factor AP-2, alpha
chr6_+_88198656 3.231 ENSMUST00000015197.7
 Gata2
GATA binding protein 2
chr11_-_97187872 2.243 ENSMUST00000001479.4
 Kpnb1
karyopherin (importin) beta 1
chr2_+_32646586 2.236 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr11_-_102317860 2.097 ENSMUST00000107117.2
 Ubtf
upstream binding transcription factor, RNA polymerase I
chr7_+_45017953 2.083 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr13_+_44730726 1.919 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
 Jarid2


jumonji, AT rich interactive domain 2


chr3_+_66981352 1.913 ENSMUST00000162036.1
 Rsrc1
arginine/serine-rich coiled-coil 1
chr13_+_38345716 1.868 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 10.8 GO:0010587 miRNA catabolic process(GO:0010587)
0.4 7.0 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 5.8 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
1.4 5.7 GO:0042414 epinephrine metabolic process(GO:0042414)
0.6 5.7 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742) regulation of branching morphogenesis of a nerve(GO:2000172)
0.2 5.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
1.1 4.4 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.2 4.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.7 3.6 GO:0048133 NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.4 3.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.1 3.3 GO:0070172 oculomotor nerve development(GO:0021557) positive regulation of tooth mineralization(GO:0070172)
1.1 3.2 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725)
0.1 2.9 GO:0051602 response to electrical stimulus(GO:0051602)
0.0 2.6 GO:0002209 behavioral fear response(GO:0001662) behavioral defense response(GO:0002209)
0.1 2.4 GO:0060325 face morphogenesis(GO:0060325)
0.7 2.2 GO:0003032 detection of oxygen(GO:0003032)
0.6 2.2 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.2 2.1 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.2 2.0 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.3 1.9 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 10.2 GO:0005667 transcription factor complex(GO:0005667)
0.2 5.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 5.4 GO:0016605 PML body(GO:0016605)
0.3 3.9 GO:0016589 NURF complex(GO:0016589)
0.0 2.7 GO:0072562 blood microparticle(GO:0072562)
0.3 2.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 2.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 2.1 GO:0001650 fibrillar center(GO:0001650)
0.1 2.0 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.9 GO:0016607 nuclear speck(GO:0016607)
0.2 1.8 GO:0042382 paraspeckles(GO:0042382)
0.0 1.6 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.4 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 1.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 1.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 1.2 GO:0036126 sperm flagellum(GO:0036126)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 23.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.6 10.8 GO:0035198 miRNA binding(GO:0035198)
0.9 5.7 GO:0035240 dopamine binding(GO:0035240)
0.0 5.3 GO:0001047 core promoter binding(GO:0001047)
0.2 4.3 GO:0070410 co-SMAD binding(GO:0070410)
0.4 3.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 3.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 3.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 3.2 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 2.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.7 2.2 GO:0005534 galactose binding(GO:0005534)
0.1 2.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.4 2.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.3 2.0 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.2 1.9 GO:0070700 BMP receptor binding(GO:0070700)
0.5 1.8 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 1.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.6 GO:0031386 protein tag(GO:0031386)
0.1 1.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 1.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)