Motif ID: Grhl1

Z-value: 0.418


Transcription factors associated with Grhl1:

Gene SymbolEntrez IDGene Name
Grhl1 ENSMUSG00000020656.9 Grhl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Grhl1mm10_v2_chr12_+_24572276_245723080.181.6e-01Click!


Activity profile for motif Grhl1.

activity profile for motif Grhl1


Sorted Z-values histogram for motif Grhl1

Sorted Z-values for motif Grhl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Grhl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_87635974 4.069 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr8_+_80494032 3.635 ENSMUST00000063359.6
 Gypa
glycophorin A
chr18_+_56432116 2.368 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr16_-_26989974 2.356 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr10_-_79533750 1.761 ENSMUST00000166804.1
ENSMUST00000063879.5
 Ppap2c

phosphatidic acid phosphatase type 2C

chr1_+_135818593 1.715 ENSMUST00000038760.8
 Lad1
ladinin
chr10_-_128565827 1.482 ENSMUST00000131728.1
ENSMUST00000026425.6
 Pa2g4

proliferation-associated 2G4

chr14_+_75136326 1.435 ENSMUST00000145303.1
 Lcp1
lymphocyte cytosolic protein 1
chrX_+_100730178 1.423 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr4_+_109676568 1.414 ENSMUST00000102724.4
 Faf1
Fas-associated factor 1
chr2_-_105399286 1.381 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr14_+_63943666 1.347 ENSMUST00000079652.5
 Sox7
SRY-box containing gene 7
chr7_+_101321703 1.302 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
 Stard10




START domain containing 10




chr13_+_8885501 1.259 ENSMUST00000169314.2
 Idi1
isopentenyl-diphosphate delta isomerase
chr19_-_18631754 1.189 ENSMUST00000025631.6
 Ostf1
osteoclast stimulating factor 1
chr8_-_71381907 1.135 ENSMUST00000002466.8
 Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr14_-_57133268 0.990 ENSMUST00000160703.1
 Gjb6
gap junction protein, beta 6
chr17_-_56005566 0.988 ENSMUST00000043785.6
 Stap2
signal transducing adaptor family member 2
chr12_+_76417598 0.773 ENSMUST00000063977.7
 Ppp1r36
protein phosphatase 1, regulatory subunit 36
chr6_+_128438757 0.747 ENSMUST00000144745.1
 Gm10069
predicted gene 10069
chr9_+_108508005 0.691 ENSMUST00000006838.8
ENSMUST00000134939.1
 Qars

glutaminyl-tRNA synthetase

chr10_+_128747850 0.673 ENSMUST00000163377.2
 Wibg
within bgcn homolog (Drosophila)
chr2_-_151973387 0.655 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr2_+_172550761 0.644 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr4_+_141242850 0.637 ENSMUST00000138096.1
ENSMUST00000006618.2
ENSMUST00000125392.1
 Arhgef19


Rho guanine nucleotide exchange factor (GEF) 19


chr2_-_25546872 0.626 ENSMUST00000114234.1
ENSMUST00000028311.6
 Traf2

TNF receptor-associated factor 2

chr9_+_15239045 0.612 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr17_+_43389436 0.579 ENSMUST00000113599.1
 Gpr116
G protein-coupled receptor 116
chr3_-_87263703 0.575 ENSMUST00000146512.1
 Fcrls
Fc receptor-like S, scavenger receptor
chr3_-_87263518 0.519 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr8_-_69996326 0.427 ENSMUST00000177851.1
ENSMUST00000065169.4
 Gatad2a

GATA zinc finger domain containing 2A

chr7_+_12927410 0.414 ENSMUST00000045870.4
 2310014L17Rik
RIKEN cDNA 2310014L17 gene
chr4_-_155086271 0.410 ENSMUST00000030914.3
 Rer1
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
chr7_-_102065044 0.401 ENSMUST00000130074.1
ENSMUST00000131104.1
ENSMUST00000096639.5
 Rnf121


ring finger protein 121


chr8_+_123477859 0.391 ENSMUST00000001520.7
 Afg3l1
AFG3(ATPase family gene 3)-like 1 (yeast)
chr7_+_65693417 0.369 ENSMUST00000032726.7
ENSMUST00000107495.3
 Tm2d3

TM2 domain containing 3

chr6_-_113377376 0.286 ENSMUST00000043333.2
 Tada3
transcriptional adaptor 3
chr12_-_54656496 0.278 ENSMUST00000056228.6
 Sptssa
serine palmitoyltransferase, small subunit A
chr12_+_90738201 0.275 ENSMUST00000181874.1
 Gm26512
predicted gene, 26512
chr6_-_113377510 0.259 ENSMUST00000099118.2
 Tada3
transcriptional adaptor 3
chr5_+_130029277 0.220 ENSMUST00000026608.7
 Crcp
calcitonin gene-related peptide-receptor component protein
chr17_-_34628005 0.195 ENSMUST00000166040.2
 Ppt2
palmitoyl-protein thioesterase 2
chr7_+_65693447 0.164 ENSMUST00000143508.1
 Tm2d3
TM2 domain containing 3
chr4_+_108834601 0.130 ENSMUST00000030296.8
 Txndc12
thioredoxin domain containing 12 (endoplasmic reticulum)
chrX_-_38456407 0.124 ENSMUST00000074913.5
ENSMUST00000016678.7
ENSMUST00000061755.8
 Lamp2


lysosomal-associated membrane protein 2


chr17_+_36837123 0.118 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
 Trim26





tripartite motif-containing 26





chr9_-_107541816 0.042 ENSMUST00000041459.3
 Cyb561d2
cytochrome b-561 domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.7 3.6 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.2 1.4 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 0.6 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.2 1.3 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.2 0.6 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 1.4 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.4 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.4 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.1 1.4 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 1.1 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 2.4 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.5 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.4 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 1.3 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 1.3 GO:0001706 endoderm formation(GO:0001706)
0.0 0.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.1 GO:0061684 chaperone-mediated autophagy(GO:0061684)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.2 1.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.4 GO:0005745 m-AAA complex(GO:0005745)
0.1 1.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.0 GO:0005922 connexon complex(GO:0005922)
0.1 1.4 GO:0001891 phagocytic cup(GO:0001891) podosome(GO:0002102)
0.1 4.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 2.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 1.7 GO:0005604 basement membrane(GO:0005604)
0.0 3.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.4 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 1.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758)
0.1 1.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.2 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 0.6 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0 0.4 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 1.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.4 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.7 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812)