Motif ID: Gsx1_Alx1_Mixl1_Lbx2

Z-value: 0.593

Transcription factors associated with Gsx1_Alx1_Mixl1_Lbx2:

Gene SymbolEntrez IDGene Name
Alx1 ENSMUSG00000036602.7 Alx1
Gsx1 ENSMUSG00000053129.5 Gsx1
Lbx2 ENSMUSG00000034968.2 Lbx2
Mixl1 ENSMUSG00000026497.7 Mixl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx1mm10_v2_chr5_+_147188678_147188696-0.453.4e-04Click!
Alx1mm10_v2_chr10_-_103028771_103028782-0.436.4e-04Click!


Activity profile for motif Gsx1_Alx1_Mixl1_Lbx2.

activity profile for motif Gsx1_Alx1_Mixl1_Lbx2


Sorted Z-values histogram for motif Gsx1_Alx1_Mixl1_Lbx2

Sorted Z-values for motif Gsx1_Alx1_Mixl1_Lbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx1_Alx1_Mixl1_Lbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_84417359 7.423 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr2_+_20737306 7.068 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr13_+_23574381 5.503 ENSMUST00000090776.4
 Hist1h2ad
histone cluster 1, H2ad
chr2_+_116067213 5.034 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr2_-_116067391 4.251 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr5_-_62766153 4.048 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_143933204 3.894 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr7_+_103550368 3.506 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr9_+_118478182 2.796 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr7_+_29071597 2.787 ENSMUST00000180926.1
 Gm26604
predicted gene, 26604
chr9_+_118478344 2.780 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_-_55919605 2.666 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr8_+_45658666 2.203 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr17_+_45734506 2.048 ENSMUST00000180558.1
 F630040K05Rik
RIKEN cDNA F630040K05 gene
chr6_-_126645784 2.011 ENSMUST00000055168.3
 Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr4_-_155056784 1.974 ENSMUST00000131173.2
 Plch2
phospholipase C, eta 2
chr11_+_29373618 1.965 ENSMUST00000040182.6
ENSMUST00000109477.1
 Ccdc88a

coiled coil domain containing 88A

chr16_-_63864114 1.939 ENSMUST00000064405.6
 Epha3
Eph receptor A3
chr8_+_45658731 1.909 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr13_+_23575753 1.893 ENSMUST00000105105.1
 Hist1h3d
histone cluster 1, H3d

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 9.4 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 6.8 GO:0006342 chromatin silencing(GO:0006342)
0.2 6.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 5.7 GO:0021860 pyramidal neuron development(GO:0021860)
1.9 5.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 3.5 GO:0007608 sensory perception of smell(GO:0007608)
0.5 3.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 2.6 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 2.5 GO:0048706 embryonic skeletal system development(GO:0048706)
0.8 2.3 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 2.3 GO:0006334 nucleosome assembly(GO:0006334)
0.3 2.2 GO:0019532 oxalate transport(GO:0019532)
0.1 2.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.7 2.1 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 2.1 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.7 2.0 GO:0050975 sensory perception of touch(GO:0050975)
0.1 2.0 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.6 1.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 1.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.5 GO:0002227 innate immune response in mucosa(GO:0002227)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 7.1 GO:0000790 nuclear chromatin(GO:0000790)
0.1 4.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 4.0 GO:0005874 microtubule(GO:0005874)
0.0 3.9 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 3.8 GO:0070469 respiratory chain(GO:0070469)
0.8 2.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 2.2 GO:0000786 nucleosome(GO:0000786)
0.0 2.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.5 2.1 GO:0060187 cell pole(GO:0060187)
0.1 1.8 GO:0043205 fibril(GO:0043205)
0.1 1.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.8 GO:0030027 lamellipodium(GO:0030027)
0.1 1.7 GO:0030673 axolemma(GO:0030673)
0.1 1.4 GO:0000124 SAGA complex(GO:0000124)
0.1 1.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.3 1.0 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 1.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 0.9 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 9.4 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 6.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 5.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.4 4.5 GO:0038191 neuropilin binding(GO:0038191)
0.6 3.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 3.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 3.3 GO:0042393 histone binding(GO:0042393)
0.1 2.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 2.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.2 2.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 2.2 GO:0043422 protein kinase B binding(GO:0043422)
0.1 2.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 1.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.4 1.8 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.3 1.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 1.5 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)