Motif ID: Gtf2i_Gtf2f1

Z-value: 2.866

Transcription factors associated with Gtf2i_Gtf2f1:

Gene SymbolEntrez IDGene Name
Gtf2f1 ENSMUSG00000002658.9 Gtf2f1
Gtf2i ENSMUSG00000060261.9 Gtf2i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gtf2imm10_v2_chr5_-_134314637_1343146760.321.4e-02Click!
Gtf2f1mm10_v2_chr17_-_57011271_57011326-0.302.0e-02Click!


Activity profile for motif Gtf2i_Gtf2f1.

activity profile for motif Gtf2i_Gtf2f1


Sorted Z-values histogram for motif Gtf2i_Gtf2f1

Sorted Z-values for motif Gtf2i_Gtf2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gtf2i_Gtf2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66948419 78.486 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr7_+_44310213 43.819 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr14_-_55116935 41.707 ENSMUST00000022819.5
 Jph4
junctophilin 4
chr1_-_56971762 36.118 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr16_-_74411292 29.337 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chrX_-_104201126 28.336 ENSMUST00000056502.6
ENSMUST00000118314.1
 C77370

expressed sequence C77370

chr6_-_32588192 27.971 ENSMUST00000115096.2
 Plxna4
plexin A4
chr9_+_40686002 27.816 ENSMUST00000034522.7
 Clmp
CXADR-like membrane protein
chr7_-_126949499 27.574 ENSMUST00000106339.1
ENSMUST00000052937.5
 Asphd1

aspartate beta-hydroxylase domain containing 1

chr5_-_44799643 26.751 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr16_-_74411776 25.358 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr16_-_42340595 24.502 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr13_+_42709482 24.438 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr2_+_136713444 24.425 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr5_-_120711927 24.131 ENSMUST00000031607.6
 Dtx1
deltex 1 homolog (Drosophila)
chr7_-_78578308 23.792 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr1_-_72536930 23.683 ENSMUST00000047786.5
 March4
membrane-associated ring finger (C3HC4) 4
chr8_+_112570043 23.366 ENSMUST00000034225.6
ENSMUST00000118171.1
 Cntnap4

contactin associated protein-like 4

chr10_+_13966268 23.209 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr2_+_37516618 23.124 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 590 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.9 94.7 GO:2000821 regulation of grooming behavior(GO:2000821)
5.4 80.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
7.8 78.5 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
22.7 68.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
10.7 64.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
5.1 60.9 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
4.6 55.8 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.9 51.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
11.4 45.8 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
6.3 44.1 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)
14.4 43.2 GO:0046959 habituation(GO:0046959)
0.6 42.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
2.4 38.5 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
3.1 36.9 GO:0016082 synaptic vesicle priming(GO:0016082)
0.7 36.1 GO:0046513 ceramide biosynthetic process(GO:0046513)
11.7 35.0 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.4 34.3 GO:0035640 exploration behavior(GO:0035640)
8.2 32.7 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
5.4 32.2 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
1.3 31.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 173.1 GO:0060076 excitatory synapse(GO:0060076)
2.2 125.2 GO:0042734 presynaptic membrane(GO:0042734)
5.9 123.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.8 114.4 GO:0070382 exocytic vesicle(GO:0070382)
0.3 98.3 GO:0045202 synapse(GO:0045202)
2.3 80.7 GO:0055038 recycling endosome membrane(GO:0055038)
3.1 77.2 GO:0030673 axolemma(GO:0030673)
13.1 65.3 GO:0030314 junctional membrane complex(GO:0030314)
3.8 63.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.7 52.7 GO:0043204 perikaryon(GO:0043204)
1.9 51.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.5 51.6 GO:0000118 histone deacetylase complex(GO:0000118)
3.1 49.8 GO:0032279 asymmetric synapse(GO:0032279)
1.8 49.3 GO:0060077 inhibitory synapse(GO:0060077)
1.5 45.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.6 44.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.7 42.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
7.8 38.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
3.6 36.4 GO:0032591 dendritic spine membrane(GO:0032591)
8.1 32.5 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 350 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 133.0 GO:0045296 cadherin binding(GO:0045296)
0.3 96.7 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.6 83.7 GO:0017124 SH3 domain binding(GO:0017124)
0.7 71.2 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
7.6 68.2 GO:0008046 axon guidance receptor activity(GO:0008046)
2.6 62.1 GO:0017075 syntaxin-1 binding(GO:0017075)
1.7 59.4 GO:0070412 R-SMAD binding(GO:0070412)
8.7 51.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
6.2 49.5 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
2.7 48.2 GO:0050321 tau-protein kinase activity(GO:0050321)
6.7 46.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
11.5 46.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
1.7 43.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.9 40.7 GO:0045499 chemorepellent activity(GO:0045499)
4.0 39.8 GO:0031749 D2 dopamine receptor binding(GO:0031749)
2.8 39.8 GO:0017154 semaphorin receptor activity(GO:0017154)
2.8 39.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
6.5 38.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.3 36.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.8 35.1 GO:0034185 apolipoprotein binding(GO:0034185)