Motif ID: Hand1

Z-value: 1.251


Transcription factors associated with Hand1:

Gene SymbolEntrez IDGene Name
Hand1 ENSMUSG00000037335.7 Hand1



Activity profile for motif Hand1.

activity profile for motif Hand1


Sorted Z-values histogram for motif Hand1

Sorted Z-values for motif Hand1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hand1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_30445508 14.903 ENSMUST00000006828.7
 Aplp1
amyloid beta (A4) precursor-like protein 1
chr15_+_81936911 13.994 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr19_-_59076069 12.243 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr15_+_92051153 10.840 ENSMUST00000169825.1
 Cntn1
contactin 1
chr8_+_84723003 9.394 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr4_-_20778527 8.233 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3
chr14_-_73385225 8.193 ENSMUST00000022704.7
 Itm2b
integral membrane protein 2B
chr15_+_81936753 8.177 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr8_-_109251698 7.612 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr11_+_57011945 7.239 ENSMUST00000094179.4
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr4_-_138396438 7.218 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr1_+_75507077 7.069 ENSMUST00000037330.4
 Inha
inhibin alpha
chr2_-_168741752 7.001 ENSMUST00000029060.4
 Atp9a
ATPase, class II, type 9A
chr11_+_57011798 6.689 ENSMUST00000036315.9
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr15_+_80097866 6.677 ENSMUST00000143928.1
 Syngr1
synaptogyrin 1
chr5_+_19907502 6.579 ENSMUST00000101558.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr19_-_4698315 6.287 ENSMUST00000096325.3
 Gm960
predicted gene 960
chr1_-_176807124 6.262 ENSMUST00000057037.7
 Cep170
centrosomal protein 170
chr11_+_32000496 6.255 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chr11_-_81968415 6.087 ENSMUST00000066197.6
 Asic2
acid-sensing (proton-gated) ion channel 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 23.1 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.0 15.9 GO:0006397 mRNA processing(GO:0006397)
5.0 14.9 GO:0071873 response to norepinephrine(GO:0071873)
0.6 13.9 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.5 13.9 GO:0045838 positive regulation of membrane potential(GO:0045838)
1.4 11.4 GO:2000809 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809)
0.6 9.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
3.2 9.7 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
1.2 9.3 GO:0097369 sodium ion import(GO:0097369)
1.5 8.8 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.1 8.8 GO:0006906 vesicle fusion(GO:0006906)
0.3 8.1 GO:0097320 membrane tubulation(GO:0097320)
1.6 7.9 GO:2001025 positive regulation of response to drug(GO:2001025)
0.7 7.5 GO:1900112 regulation of histone H3-K9 trimethylation(GO:1900112) negative regulation of histone H3-K9 trimethylation(GO:1900113)
1.2 7.1 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.2 7.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.4 6.9 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.8 6.9 GO:0071420 cellular response to histamine(GO:0071420)
0.7 6.8 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 6.7 GO:0016042 lipid catabolic process(GO:0016042)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 22.9 GO:0043198 dendritic shaft(GO:0043198)
2.9 17.5 GO:0044308 axonal spine(GO:0044308)
0.2 12.7 GO:0042734 presynaptic membrane(GO:0042734)
2.3 11.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 9.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.5 9.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
1.6 9.6 GO:1990635 proximal dendrite(GO:1990635)
0.0 9.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.2 8.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 8.2 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.7 8.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 7.8 GO:0031225 anchored component of membrane(GO:0031225)
0.2 7.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 7.5 GO:0005721 pericentric heterochromatin(GO:0005721)
2.4 7.1 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.1 7.0 GO:0055037 recycling endosome(GO:0055037)
0.1 6.8 GO:0031985 Golgi cisterna(GO:0031985)
0.1 6.3 GO:0005814 centriole(GO:0005814)
0.9 6.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 5.9 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 14.9 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
2.0 13.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.9 11.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 10.6 GO:0017124 SH3 domain binding(GO:0017124)
1.6 9.7 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.5 9.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 9.5 GO:0001948 glycoprotein binding(GO:0001948)
0.2 9.4 GO:0030276 clathrin binding(GO:0030276)
0.2 8.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 8.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 7.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.4 7.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
1.0 7.1 GO:0034711 inhibin binding(GO:0034711)
0.4 7.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 7.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 6.8 GO:0017160 Ral GTPase binding(GO:0017160)
1.0 6.3 GO:0032051 clathrin light chain binding(GO:0032051)
0.5 6.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 6.1 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 6.1 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)