Motif ID: Hcfc1_Six5_Smarcc2_Zfp143

Z-value: 3.043

Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143:

Gene SymbolEntrez IDGene Name
Hcfc1 ENSMUSG00000031386.8 Hcfc1
Six5 ENSMUSG00000040841.5 Six5
Smarcc2 ENSMUSG00000025369.8 Smarcc2
Zfp143 ENSMUSG00000061079.7 Zfp143

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smarcc2mm10_v2_chr10_+_128459236_1284592480.283.1e-02Click!
Zfp143mm10_v2_chr7_+_110061702_1100617320.113.9e-01Click!
Six5mm10_v2_chr7_+_19094594_190946330.066.3e-01Click!
Hcfc1mm10_v2_chrX_-_73966329_739663760.066.6e-01Click!


Activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143.

activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143


Sorted Z-values histogram for motif Hcfc1_Six5_Smarcc2_Zfp143

Sorted Z-values for motif Hcfc1_Six5_Smarcc2_Zfp143



Network of associatons between targets according to the STRING database.



First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_116708312 9.158 ENSMUST00000030453.4
 Mmachc
methylmalonic aciduria cblC type, with homocystinuria
chr5_-_149636331 7.933 ENSMUST00000074846.7
ENSMUST00000110498.1
ENSMUST00000127977.1
ENSMUST00000132412.1
 Hsph1



heat shock 105kDa/110kDa protein 1



chr4_+_116708687 7.847 ENSMUST00000135499.1
 Ccdc163
coiled-coil domain containing 163
chr1_+_151428612 6.958 ENSMUST00000065625.5
 Trmt1l
tRNA methyltransferase 1 like
chr7_+_44384803 6.898 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr9_+_83548309 6.584 ENSMUST00000113215.3
 Sh3bgrl2
SH3 domain binding glutamic acid-rich protein like 2
chr7_+_44384604 6.563 ENSMUST00000130707.1
ENSMUST00000130844.1
 Syt3

synaptotagmin III

chr17_-_23673825 6.483 ENSMUST00000115490.1
ENSMUST00000047436.4
ENSMUST00000138190.1
ENSMUST00000095579.4
 Thoc6



THO complex 6 homolog (Drosophila)



chr7_+_19119853 6.438 ENSMUST00000053109.3
 Fbxo46
F-box protein 46
chr8_+_71464910 6.387 ENSMUST00000048914.6
 Mrpl34
mitochondrial ribosomal protein L34
chr17_+_25985815 6.382 ENSMUST00000180932.1
 1700022N22Rik
RIKEN cDNA 1700022N22 gene
chr7_+_6172482 6.332 ENSMUST00000108567.1
ENSMUST00000054680.5
ENSMUST00000108566.1
 Zfp444


zinc finger protein 444


chr11_+_69995874 6.064 ENSMUST00000101526.2
 Phf23
PHD finger protein 23
chr4_+_83417715 6.058 ENSMUST00000030206.3
ENSMUST00000071544.4
 Snapc3

small nuclear RNA activating complex, polypeptide 3

chr1_+_172482199 5.978 ENSMUST00000135267.1
ENSMUST00000052629.6
ENSMUST00000111235.2
 Igsf9


immunoglobulin superfamily, member 9


chr11_+_69995777 5.959 ENSMUST00000018716.3
 Phf23
PHD finger protein 23
chr7_+_44468020 5.891 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
 Josd2


Josephin domain containing 2


chr2_+_118598209 5.884 ENSMUST00000038341.7
 Bub1b
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)
chr14_+_64950037 5.879 ENSMUST00000043914.5
 Ints9
integrator complex subunit 9
chr4_+_116708624 5.850 ENSMUST00000106463.1
 Ccdc163
coiled-coil domain containing 163

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 397 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 28.4 GO:0006412 translation(GO:0006412)
1.0 18.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 18.5 GO:1903506 regulation of nucleic acid-templated transcription(GO:1903506)
0.1 14.4 GO:0016579 protein deubiquitination(GO:0016579)
0.1 13.5 GO:0008380 RNA splicing(GO:0008380)
0.1 12.8 GO:0098792 xenophagy(GO:0098792)
1.1 12.6 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
4.0 12.0 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 11.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 10.2 GO:0006378 mRNA polyadenylation(GO:0006378)
1.6 9.8 GO:0009235 cobalamin metabolic process(GO:0009235)
0.6 9.0 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 8.3 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.5 8.1 GO:0006107 oxaloacetate metabolic process(GO:0006107)
2.0 7.9 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.7 7.9 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.4 7.7 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 7.6 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.3 6.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
1.6 6.5 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 215 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 140.5 GO:0005634 nucleus(GO:0005634)
0.1 22.2 GO:0070382 exocytic vesicle(GO:0070382)
0.1 20.1 GO:0005840 ribosome(GO:0005840)
0.0 17.7 GO:0005730 nucleolus(GO:0005730)
0.1 14.9 GO:0005874 microtubule(GO:0005874)
0.5 14.7 GO:0060077 inhibitory synapse(GO:0060077)
0.0 13.0 GO:0005739 mitochondrion(GO:0005739)
1.4 12.6 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 11.3 GO:0005813 centrosome(GO:0005813)
0.4 9.9 GO:0071565 nBAF complex(GO:0071565)
0.2 9.9 GO:0016592 mediator complex(GO:0016592)
0.3 9.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 9.8 GO:0000776 kinetochore(GO:0000776)
0.0 9.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 9.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 8.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 8.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 8.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.7 7.5 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
1.1 7.4 GO:0001940 male pronucleus(GO:0001940)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 274 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 47.4 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 43.7 GO:0003723 RNA binding(GO:0003723)
0.2 39.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 20.1 GO:0008270 zinc ion binding(GO:0008270)
0.6 18.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 17.8 GO:0003774 motor activity(GO:0003774)
0.6 12.5 GO:0008242 omega peptidase activity(GO:0008242)
0.1 12.3 GO:0002039 p53 binding(GO:0002039)
0.1 12.0 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 11.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 11.5 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
1.4 11.4 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
1.4 9.8 GO:0031419 cobalamin binding(GO:0031419)
0.2 9.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.4 9.0 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.3 9.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.7 8.8 GO:1990226 histone methyltransferase binding(GO:1990226)
0.3 7.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 7.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 6.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)