Motif ID: Hdx

Z-value: 6.534


Transcription factors associated with Hdx:

Gene SymbolEntrez IDGene Name
Hdx ENSMUSG00000034551.6 Hdx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hdxmm10_v2_chrX_-_111697069_111697127-0.019.6e-01Click!


Activity profile for motif Hdx.

activity profile for motif Hdx


Sorted Z-values histogram for motif Hdx

Sorted Z-values for motif Hdx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hdx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_3017408 409.252 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 361.440 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3023547 336.190 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3005125 319.843 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3000922 293.692 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3034599 289.343 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3027439 266.874 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3025417 252.846 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr14_-_19418930 237.475 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 211.316 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3004457 194.329 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3036877 176.026 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3037111 165.256 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3013140 159.809 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr2_-_98667264 119.778 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr6_-_23248264 65.666 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr13_+_24327415 24.943 ENSMUST00000167746.1
 Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr16_-_26989974 23.167 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr3_-_154330543 19.015 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chrX_-_143827391 12.953 ENSMUST00000087316.5
 Capn6
calpain 6
chr7_+_46847128 10.566 ENSMUST00000005051.4
 Ldha
lactate dehydrogenase A
chr2_-_129371131 9.231 ENSMUST00000028881.7
 Il1b
interleukin 1 beta
chr17_+_17402672 9.224 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr15_+_10177623 8.891 ENSMUST00000124470.1
 Prlr
prolactin receptor
chr5_-_27501362 8.784 ENSMUST00000155721.1
ENSMUST00000053257.3
 Speer4b

spermatogenesis associated glutamate (E)-rich protein 4b

chrX_+_169879596 8.509 ENSMUST00000112105.1
ENSMUST00000078947.5
 Mid1

midline 1

chr12_-_27160311 8.278 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
 Gm9866


predicted gene 9866


chrX_-_21089229 8.103 ENSMUST00000040667.6
 Zfp300
zinc finger protein 300
chr13_+_43370710 7.457 ENSMUST00000066804.4
 Sirt5
sirtuin 5
chr2_-_72986716 6.365 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr12_-_23780265 6.157 ENSMUST00000072014.4
 Gm10330
predicted gene 10330
chr11_-_76509419 5.885 ENSMUST00000094012.4
 Abr
active BCR-related gene
chr11_+_82101836 5.626 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr6_+_30568367 5.585 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr2_-_165368723 5.501 ENSMUST00000141140.1
ENSMUST00000103085.1
 Zfp663

zinc finger protein 663

chr13_-_113663670 5.479 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr6_+_54267131 5.189 ENSMUST00000114402.2
 Chn2
chimerin (chimaerin) 2
chr11_+_98446826 5.020 ENSMUST00000019456.4
 Grb7
growth factor receptor bound protein 7
chrX_+_143518671 4.840 ENSMUST00000134402.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr9_+_45055166 4.823 ENSMUST00000114664.1
ENSMUST00000093856.3
 Mpzl3

myelin protein zero-like 3

chr14_-_19977040 4.788 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr14_-_19977151 4.601 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr7_+_13398115 4.487 ENSMUST00000005791.7
 Cabp5
calcium binding protein 5
chr8_+_84415348 4.482 ENSMUST00000121390.1
ENSMUST00000122053.1
 Cacna1a

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

chr4_-_115133977 4.460 ENSMUST00000051400.7
 Cyp4x1
cytochrome P450, family 4, subfamily x, polypeptide 1
chr1_-_84935089 4.213 ENSMUST00000027422.5
 Slc16a14
solute carrier family 16 (monocarboxylic acid transporters), member 14
chr10_+_7667503 4.190 ENSMUST00000040135.8
 Nup43
nucleoporin 43
chrX_+_143518576 4.170 ENSMUST00000033640.7
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr4_-_133753611 4.065 ENSMUST00000145664.2
ENSMUST00000105897.3
 Arid1a

AT rich interactive domain 1A (SWI-like)

chr9_+_53771499 3.881 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr13_-_67729109 3.865 ENSMUST00000073157.6
 Zfp71-rs1
zinc finger protein 71, related sequence
chr4_-_43031370 3.486 ENSMUST00000138030.1
 Stoml2
stomatin (Epb7.2)-like 2
chr1_+_87327044 3.431 ENSMUST00000173173.1
 Gigyf2
GRB10 interacting GYF protein 2
chr7_-_19359477 3.193 ENSMUST00000047036.8
 Cd3eap
CD3E antigen, epsilon polypeptide associated protein
chr19_+_12460749 3.041 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1
chr2_-_121806988 3.004 ENSMUST00000110592.1
 Frmd5
FERM domain containing 5
chr1_+_87327008 2.992 ENSMUST00000172794.1
ENSMUST00000164992.2
 Gigyf2

GRB10 interacting GYF protein 2

chr4_+_89137122 2.868 ENSMUST00000058030.7
 Mtap
methylthioadenosine phosphorylase
chr4_-_43031429 2.861 ENSMUST00000136326.1
 Stoml2
stomatin (Epb7.2)-like 2
chr5_+_90794530 2.664 ENSMUST00000031322.6
 Cxcl15
chemokine (C-X-C motif) ligand 15
chr15_+_100761741 2.617 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8
chr15_-_80083374 2.598 ENSMUST00000081650.7
 Rpl3
ribosomal protein L3
chr4_+_43406435 2.554 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr14_+_70774304 2.543 ENSMUST00000022698.7
 Dok2
docking protein 2
chr1_-_54194048 2.472 ENSMUST00000120904.1
 Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr11_-_45955465 2.401 ENSMUST00000011398.6
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr11_+_117115133 2.367 ENSMUST00000021177.8
 Sec14l1
SEC14-like 1 (S. cerevisiae)
chr4_-_129640959 2.320 ENSMUST00000132217.1
ENSMUST00000130017.1
ENSMUST00000154105.1
 Txlna


taxilin alpha


chr5_+_30013141 2.262 ENSMUST00000026845.7
 Il6
interleukin 6
chr4_-_129640691 2.238 ENSMUST00000084264.5
 Txlna
taxilin alpha
chr16_+_14705832 2.134 ENSMUST00000023356.6
 Snai2
snail homolog 2 (Drosophila)
chr16_+_37539883 2.122 ENSMUST00000023524.6
 Rabl3
RAB, member of RAS oncogene family-like 3
chr1_-_172027251 1.923 ENSMUST00000138714.1
 Vangl2
vang-like 2 (van gogh, Drosophila)
chr8_-_85025268 1.902 ENSMUST00000064314.8
 Asna1
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr11_-_69369377 1.891 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr14_+_73138755 1.859 ENSMUST00000171070.1
 Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr11_-_45955183 1.665 ENSMUST00000109254.1
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr2_+_174415804 1.630 ENSMUST00000109075.1
ENSMUST00000016397.6
 Nelfcd

negative elongation factor complex member C/D, Th1l

chr13_+_60601921 1.524 ENSMUST00000077453.5
 Dapk1
death associated protein kinase 1
chr19_+_8953826 1.498 ENSMUST00000096239.5
 Tut1
terminal uridylyl transferase 1, U6 snRNA-specific
chr11_+_95666957 1.496 ENSMUST00000125172.1
ENSMUST00000036374.5
 Phb

prohibitin

chr4_-_88722454 1.482 ENSMUST00000094993.2
 Klhl9
kelch-like 9
chr11_+_117115195 1.470 ENSMUST00000103026.3
ENSMUST00000090433.5
 Sec14l1

SEC14-like 1 (S. cerevisiae)

chr13_+_60602182 1.364 ENSMUST00000044083.7
 Dapk1
death associated protein kinase 1
chr9_-_60649793 1.305 ENSMUST00000053171.7
 Lrrc49
leucine rich repeat containing 49
chr2_-_121807024 1.284 ENSMUST00000138157.1
 Frmd5
FERM domain containing 5
chr4_+_124880899 1.226 ENSMUST00000059343.6
 Epha10
Eph receptor A10
chr14_+_24490678 1.207 ENSMUST00000169826.1
ENSMUST00000112384.3
 Rps24

ribosomal protein S24

chr10_-_80918212 1.123 ENSMUST00000057623.7
ENSMUST00000179022.1
 Lmnb2

lamin B2

chr15_-_99087817 1.083 ENSMUST00000064462.3
 C1ql4
complement component 1, q subcomponent-like 4
chr3_-_54915867 0.906 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr15_-_82047579 0.886 ENSMUST00000166578.1
ENSMUST00000080622.7
 Nhp2l1

NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)

chr10_-_112928974 0.829 ENSMUST00000099276.2
 Atxn7l3b
ataxin 7-like 3B
chr5_+_32863700 0.733 ENSMUST00000149350.1
ENSMUST00000118698.1
ENSMUST00000150130.1
ENSMUST00000087897.4
ENSMUST00000119705.1
ENSMUST00000125574.1
ENSMUST00000049780.6
 Depdc5






DEP domain containing 5






chr2_+_3118335 0.623 ENSMUST00000115099.2
 Fam171a1
family with sequence similarity 171, member A1
chr7_-_44257378 0.525 ENSMUST00000107945.1
ENSMUST00000118216.1
 Acpt

acid phosphatase, testicular

chr2_-_130629994 0.407 ENSMUST00000028761.4
ENSMUST00000110262.1
 Ubox5
Fastkd5
U box domain containing 5
FAST kinase domains 5
chr12_-_87775755 0.335 ENSMUST00000164517.2
 Gm21319
predicted gene, 21319
chr1_+_119526125 0.251 ENSMUST00000183952.1
 TMEM185B
Transmembrane protein 185B
chr13_+_21717626 0.146 ENSMUST00000091754.2
 Hist1h3h
histone cluster 1, H3h
chr5_+_25247344 0.087 ENSMUST00000114950.1
 Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr18_+_37477768 0.075 ENSMUST00000051442.5
 Pcdhb16
protocadherin beta 16

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
10.9 65.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
8.3 24.9 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
3.1 9.2 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
2.1 6.3 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
2.1 10.6 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
1.9 5.6 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
1.8 8.9 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) prolactin signaling pathway(GO:0038161)
1.5 4.5 GO:0061526 acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) musculoskeletal movement, spinal reflex action(GO:0050883) acetylcholine secretion(GO:0061526)
1.2 5.9 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
1.0 3.8 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.8 2.3 GO:0002295 T-helper cell lineage commitment(GO:0002295)
0.7 2.9 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.7 2.1 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.7 23.2 GO:0006270 DNA replication initiation(GO:0006270)
0.7 4.1 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.6 1.9 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.4 7.5 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.4 9.0 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.4 9.2 GO:0097352 autophagosome maturation(GO:0097352)
0.4 19.0 GO:0021884 forebrain neuron development(GO:0021884)
0.3 1.5 GO:0002922 positive regulation of humoral immune response(GO:0002922) progesterone receptor signaling pathway(GO:0050847)
0.2 1.5 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 5.0 GO:0034063 stress granule assembly(GO:0034063)
0.2 8.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 5.0 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.2 2.7 GO:0071624 positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 2.6 GO:0015701 bicarbonate transport(GO:0015701)
0.1 2566.2 GO:0008150 biological_process(GO:0008150)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 19.0 GO:0001674 female germ cell nucleus(GO:0001674)
0.8 10.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.8 2.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.5 1.9 GO:0060187 cell pole(GO:0060187)
0.4 1.6 GO:0032021 NELF complex(GO:0032021)
0.4 6.3 GO:0042101 T cell receptor complex(GO:0042101)
0.4 4.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.2 13.0 GO:0005876 spindle microtubule(GO:0005876)
0.2 4.1 GO:0071564 npBAF complex(GO:0071564)
0.2 3.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 9.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 1.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 0.7 GO:1990130 Iml1 complex(GO:1990130)
0.2 0.9 GO:0001651 dense fibrillar component(GO:0001651)
0.2 1.1 GO:0005638 lamin filament(GO:0005638)
0.1 2727.8 GO:0005575 cellular_component(GO:0005575)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
8.3 24.9 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
2.6 10.6 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
2.1 6.3 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
1.4 5.6 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
1.0 2.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.9 4.5 GO:0070330 aromatase activity(GO:0070330)
0.7 9.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.7 13.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.5 4.1 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.5 1.5 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.5 7.5 GO:0070403 NAD+ binding(GO:0070403)
0.3 2.6 GO:0008097 5S rRNA binding(GO:0008097)
0.3 4.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 9.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.3 5.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.3 1.5 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.3 2.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.3 8.9 GO:0017046 peptide hormone binding(GO:0017046)
0.3 2.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 2.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 3.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 1.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 5.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 0.9 GO:0034511 U4 snRNA binding(GO:0030621) U3 snoRNA binding(GO:0034511)
0.2 36.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 2632.9 GO:0003674 molecular_function(GO:0003674)