Motif ID: Hes1

Z-value: 1.355


Transcription factors associated with Hes1:

Gene SymbolEntrez IDGene Name
Hes1 ENSMUSG00000022528.7 Hes1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes1mm10_v2_chr16_+_30065333_300653510.756.3e-12Click!


Activity profile for motif Hes1.

activity profile for motif Hes1


Sorted Z-values histogram for motif Hes1

Sorted Z-values for motif Hes1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 25.685 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 24.409 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr4_+_65124174 9.795 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr17_-_25797032 9.407 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr1_+_153652943 7.880 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr19_+_60144682 7.769 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr12_+_110279228 7.728 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr11_-_89302545 6.824 ENSMUST00000061728.3
 Nog
noggin
chr1_-_166309585 6.176 ENSMUST00000168347.1
 5330438I03Rik
RIKEN cDNA 5330438I03 gene
chr6_+_120666388 5.859 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr9_-_75409951 5.783 ENSMUST00000049355.10
 Mapk6
mitogen-activated protein kinase 6
chr8_+_119446719 5.654 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr1_-_175692624 5.441 ENSMUST00000027809.7
 Opn3
opsin 3
chr19_-_24555819 5.404 ENSMUST00000112673.2
ENSMUST00000025800.8
 Pip5k1b

phosphatidylinositol-4-phosphate 5-kinase, type 1 beta

chr4_+_116877376 5.236 ENSMUST00000044823.3
 Zswim5
zinc finger SWIM-type containing 5
chrX_-_141725181 5.179 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr7_+_45017953 5.090 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr11_-_60811228 4.803 ENSMUST00000018744.8
 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr2_+_156840966 4.793 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr13_-_81710937 4.681 ENSMUST00000161920.1
ENSMUST00000048993.5
 Polr3g

polymerase (RNA) III (DNA directed) polypeptide G


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 162 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.6 50.1 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.6 9.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
2.1 8.6 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 8.3 GO:0008380 RNA splicing(GO:0008380)
1.3 7.7 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
1.2 7.3 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.1 7.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)
1.7 6.8 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.9 6.5 GO:0001842 neural fold formation(GO:0001842)
1.5 6.1 GO:0003360 brainstem development(GO:0003360)
0.5 6.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.6 5.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 5.6 GO:0031960 response to corticosteroid(GO:0031960) response to glucocorticoid(GO:0051384)
1.8 5.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 5.1 GO:0060325 face morphogenesis(GO:0060325)
1.6 4.8 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.2 4.8 GO:0038092 nodal signaling pathway(GO:0038092)
0.8 4.7 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.2 4.6 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 4.5 GO:0009409 response to cold(GO:0009409)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 30.0 GO:0005615 extracellular space(GO:0005615)
0.0 11.9 GO:0005667 transcription factor complex(GO:0005667)
0.1 10.1 GO:0030139 endocytic vesicle(GO:0030139)
0.2 7.9 GO:0032809 neuronal cell body membrane(GO:0032809)
2.0 6.1 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
1.5 5.9 GO:0090537 CERF complex(GO:0090537)
0.4 5.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 5.8 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 5.8 GO:0031225 anchored component of membrane(GO:0031225)
0.6 5.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 5.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.7 4.3 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.2 4.3 GO:0016580 Sin3 complex(GO:0016580)
0.2 4.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 4.2 GO:0016607 nuclear speck(GO:0016607)
0.0 4.1 GO:0005925 focal adhesion(GO:0005925)
0.8 4.0 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 3.9 GO:0008180 COP9 signalosome(GO:0008180)
0.0 3.9 GO:0034399 nuclear periphery(GO:0034399)
0.2 3.8 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 50.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 12.7 GO:0044822 poly(A) RNA binding(GO:0044822)
0.1 9.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 8.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.4 8.6 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 7.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 6.8 GO:0019955 cytokine binding(GO:0019955)
0.0 6.4 GO:0042393 histone binding(GO:0042393)
1.0 6.1 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 6.1 GO:0070888 E-box binding(GO:0070888)
1.0 5.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.8 5.4 GO:0009881 photoreceptor activity(GO:0009881)
0.7 5.4 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.2 5.4 GO:0004707 MAP kinase activity(GO:0004707)
1.7 5.2 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.3 5.2 GO:0051920 peroxiredoxin activity(GO:0051920)
0.1 5.2 GO:0005158 insulin receptor binding(GO:0005158)
0.1 5.1 GO:0019003 GDP binding(GO:0019003)
0.3 4.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
1.1 4.5 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)