Motif ID: Hey2

Z-value: 0.722


Transcription factors associated with Hey2:

Gene SymbolEntrez IDGene Name
Hey2 ENSMUSG00000019789.8 Hey2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hey2mm10_v2_chr10_-_30842765_308428010.133.1e-01Click!


Activity profile for motif Hey2.

activity profile for motif Hey2


Sorted Z-values histogram for motif Hey2

Sorted Z-values for motif Hey2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey2

PNG image of the network

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Top targets:


Showing 1 to 20 of 181 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_14523178 7.890 ENSMUST00000110516.2
 Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr6_-_88875035 7.218 ENSMUST00000145944.1
 Podxl2
podocalyxin-like 2
chr8_-_70700070 5.473 ENSMUST00000116172.1
 Gm11175
predicted gene 11175
chr6_+_54816906 5.335 ENSMUST00000079869.6
 Znrf2
zinc and ring finger 2
chr16_-_18621366 5.224 ENSMUST00000051160.2
 Gp1bb
glycoprotein Ib, beta polypeptide
chr11_+_113619318 5.188 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr11_-_120348513 5.103 ENSMUST00000071555.6
 Actg1
actin, gamma, cytoplasmic 1
chr4_+_33924632 5.089 ENSMUST00000057188.6
 Cnr1
cannabinoid receptor 1 (brain)
chr18_-_61911783 5.055 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr2_-_168741898 4.996 ENSMUST00000109176.1
ENSMUST00000178504.1
 Atp9a

ATPase, class II, type 9A

chr11_+_120721452 4.251 ENSMUST00000018156.5
 Rac3
RAS-related C3 botulinum substrate 3
chr19_+_6418731 4.247 ENSMUST00000113462.1
ENSMUST00000077182.6
ENSMUST00000113461.1
 Nrxn2


neurexin II


chr4_+_104367549 4.243 ENSMUST00000106830.2
 Dab1
disabled 1
chr2_+_128967383 3.848 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr2_-_85196697 3.727 ENSMUST00000099930.2
ENSMUST00000111601.1
 Lrrc55

leucine rich repeat containing 55

chr1_+_23762003 3.692 ENSMUST00000140583.1
 B3gat2
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr11_+_120721543 3.690 ENSMUST00000142229.1
 Rac3
RAS-related C3 botulinum substrate 3
chr11_+_120348678 3.678 ENSMUST00000143813.1
 0610009L18Rik
RIKEN cDNA 0610009L18 gene
chr2_-_114013619 3.449 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr7_-_25658726 3.446 ENSMUST00000071329.6
 Bckdha
branched chain ketoacid dehydrogenase E1, alpha polypeptide

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 10.3 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.2 9.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 9.3 GO:0045214 sarcomere organization(GO:0045214)
0.0 8.4 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.9 7.9 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.3 5.9 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.6 5.2 GO:0030432 peristalsis(GO:0030432)
0.0 5.2 GO:0007596 blood coagulation(GO:0007596)
1.3 5.1 GO:0031622 positive regulation of fever generation(GO:0031622)
0.1 4.9 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.0 4.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
1.4 4.2 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
1.4 4.2 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.0 3.6 GO:0007601 visual perception(GO:0007601)
0.2 3.4 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.8 3.3 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.1 3.3 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.3 3.2 GO:0071435 potassium ion export(GO:0071435)
0.1 3.2 GO:0048148 behavioral response to cocaine(GO:0048148)
0.3 3.0 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.3 GO:0031941 filamentous actin(GO:0031941)
0.0 14.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 11.0 GO:0055037 recycling endosome(GO:0055037)
0.1 5.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 5.3 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.1 4.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.8 4.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 4.2 GO:0005903 brush border(GO:0005903)
0.9 3.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.2 3.4 GO:0005922 connexon complex(GO:0005922)
0.5 3.3 GO:0005638 lamin filament(GO:0005638)
0.1 3.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.9 GO:0070382 exocytic vesicle(GO:0070382)
0.2 2.7 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 2.4 GO:0031209 SCAR complex(GO:0031209)
0.0 2.3 GO:0005581 collagen trimer(GO:0005581)
0.7 2.2 GO:0044194 cytolytic granule(GO:0044194)
0.0 2.0 GO:0030016 myofibril(GO:0030016)
0.1 1.9 GO:0002102 podosome(GO:0002102)
0.2 1.6 GO:0030991 intraciliary transport particle A(GO:0030991)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.6 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.1 10.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 8.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 7.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
1.0 5.9 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
1.7 5.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.5 4.9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.8 4.2 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1 4.2 GO:0042169 SH2 domain binding(GO:0042169)
0.1 4.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 3.9 GO:0008144 drug binding(GO:0008144)
0.3 3.4 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 3.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.6 3.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.7 3.0 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 2.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 2.8 GO:0030552 cAMP binding(GO:0030552)
0.4 2.4 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.3 2.4 GO:0050693 LBD domain binding(GO:0050693)
0.0 2.3 GO:0004713 protein tyrosine kinase activity(GO:0004713)