Motif ID: Hic2

Z-value: 2.122


Transcription factors associated with Hic2:

Gene SymbolEntrez IDGene Name
Hic2 ENSMUSG00000050240.8 Hic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hic2mm10_v2_chr16_+_17233560_17233664-0.679.0e-09Click!


Activity profile for motif Hic2.

activity profile for motif Hic2


Sorted Z-values histogram for motif Hic2

Sorted Z-values for motif Hic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 27.698 ENSMUST00000107377.3
 Tnc
tenascin C
chr11_+_104231573 25.989 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr11_+_104231390 25.843 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr11_+_104231515 22.997 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr11_+_104231465 21.922 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr5_+_98180866 20.971 ENSMUST00000112959.1
 Prdm8
PR domain containing 8
chr6_+_103510874 19.535 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr10_+_127725392 19.219 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr5_+_117781017 18.035 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr1_-_56978534 17.104 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr15_+_99224976 16.796 ENSMUST00000041415.3
 Kcnh3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr11_+_78324200 16.604 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr7_+_130936172 16.374 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr1_-_56969827 16.300 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr1_+_74854954 16.247 ENSMUST00000160379.2
 Cdk5r2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr1_-_56969864 14.681 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr12_+_61523889 14.414 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr12_-_79007276 14.305 ENSMUST00000056660.6
ENSMUST00000174721.1
 Tmem229b

transmembrane protein 229B

chr18_-_23038656 13.734 ENSMUST00000081423.6
 Nol4
nucleolar protein 4
chr12_+_16653470 13.686 ENSMUST00000111064.1
 Ntsr2
neurotensin receptor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 375 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.2 98.8 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
2.7 42.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.9 28.6 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
6.9 27.7 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
8.3 25.0 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
1.2 20.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.5 19.5 GO:0035640 exploration behavior(GO:0035640)
3.2 19.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
3.7 18.4 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
4.5 18.0 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.8 17.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.7 16.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
2.7 16.4 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
4.1 16.2 GO:0021586 pons maturation(GO:0021586)
3.7 14.9 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
2.4 14.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.9 13.8 GO:0001553 luteinization(GO:0001553)
1.1 13.7 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.7 13.6 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
1.5 13.1 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.7 96.8 GO:0045298 tubulin complex(GO:0045298)
0.6 64.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 46.6 GO:0031012 extracellular matrix(GO:0031012)
2.6 41.4 GO:0005614 interstitial matrix(GO:0005614)
0.7 41.3 GO:0042734 presynaptic membrane(GO:0042734)
1.6 29.6 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.7 28.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 27.1 GO:0043198 dendritic shaft(GO:0043198)
0.9 22.4 GO:0030673 axolemma(GO:0030673)
0.2 19.2 GO:0035097 histone methyltransferase complex(GO:0035097)
0.2 18.8 GO:0031225 anchored component of membrane(GO:0031225)
1.7 18.2 GO:0031931 TORC1 complex(GO:0031931)
0.9 18.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
1.6 18.0 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.6 17.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 17.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
5.4 16.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
1.4 15.5 GO:0002116 semaphorin receptor complex(GO:0002116)
1.3 13.9 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.2 13.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 251 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.4 100.1 GO:0034185 apolipoprotein binding(GO:0034185)
0.3 28.5 GO:0005178 integrin binding(GO:0005178)
4.6 27.7 GO:0045545 syndecan binding(GO:0045545)
3.6 25.0 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.9 23.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.4 22.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
2.6 21.0 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.6 20.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.8 19.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.5 18.6 GO:0022839 ion gated channel activity(GO:0022839)
0.2 18.6 GO:0002020 protease binding(GO:0002020)
6.0 18.0 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.4 17.6 GO:0001540 beta-amyloid binding(GO:0001540)
1.3 17.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
2.8 16.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.8 16.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
1.1 15.5 GO:0017154 semaphorin receptor activity(GO:0017154)
2.4 14.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.2 13.9 GO:0017022 myosin binding(GO:0017022)
0.7 13.7 GO:0004385 guanylate kinase activity(GO:0004385)