Motif ID: Hif1a

Z-value: 0.997


Transcription factors associated with Hif1a:

Gene SymbolEntrez IDGene Name
Hif1a ENSMUSG00000021109.7 Hif1a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hif1amm10_v2_chr12_+_73907904_73907970-0.572.5e-06Click!


Activity profile for motif Hif1a.

activity profile for motif Hif1a


Sorted Z-values histogram for motif Hif1a

Sorted Z-values for motif Hif1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hif1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_46845832 12.623 ENSMUST00000048209.9
ENSMUST00000092621.4
 Ldha

lactate dehydrogenase A

chr18_+_74442500 8.808 ENSMUST00000074157.6
 Myo5b
myosin VB
chr7_-_30973399 7.552 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr7_-_30973367 7.422 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr17_+_28769307 7.138 ENSMUST00000004986.6
 Mapk13
mitogen-activated protein kinase 13
chr19_+_25610533 6.475 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chrX_-_93832106 6.366 ENSMUST00000045748.6
 Pdk3
pyruvate dehydrogenase kinase, isoenzyme 3
chr16_+_70314087 6.311 ENSMUST00000023393.8
 Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr2_+_27886416 6.262 ENSMUST00000028280.7
 Col5a1
collagen, type V, alpha 1
chr16_+_70314119 6.179 ENSMUST00000170464.2
 Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr16_+_70313949 6.148 ENSMUST00000163832.1
 Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr1_+_74771886 5.933 ENSMUST00000006716.6
 Wnt6
wingless-related MMTV integration site 6
chr1_-_17097839 5.915 ENSMUST00000038382.4
 Jph1
junctophilin 1
chr8_+_106893616 5.680 ENSMUST00000047629.5
 Cirh1a
cirrhosis, autosomal recessive 1A (human)
chr16_+_70314057 5.675 ENSMUST00000171132.1
 Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr2_+_168081004 5.441 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr10_-_78009737 5.439 ENSMUST00000020522.8
 Pfkl
phosphofructokinase, liver, B-type
chr4_-_11386757 5.246 ENSMUST00000108313.1
ENSMUST00000108311.2
 Esrp1

epithelial splicing regulatory protein 1

chr6_-_125165707 5.166 ENSMUST00000118875.1
 Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr2_+_71873224 5.156 ENSMUST00000006669.5
 Pdk1
pyruvate dehydrogenase kinase, isoenzyme 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 23.1 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
5.0 15.0 GO:1904274 tricellular tight junction assembly(GO:1904274)
2.5 12.6 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
2.9 11.5 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
2.6 10.2 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.1 10.0 GO:0071229 cellular response to acid chemical(GO:0071229)
0.1 9.7 GO:0006413 translational initiation(GO:0006413)
2.2 8.8 GO:0032439 endosome localization(GO:0032439)
0.1 7.3 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.1 7.1 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.1 6.9 GO:0006364 rRNA processing(GO:0006364)
0.6 6.5 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
2.1 6.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.8 6.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.2 6.3 GO:0009299 mRNA transcription(GO:0009299)
2.1 6.2 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
2.0 5.9 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.5 5.4 GO:0030388 fructose 6-phosphate metabolic process(GO:0006002) fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 5.2 GO:0060441 epithelial tube branching involved in lung morphogenesis(GO:0060441)
0.5 4.7 GO:0030322 stabilization of membrane potential(GO:0030322)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 28.3 GO:0005615 extracellular space(GO:0005615)
2.5 15.0 GO:0061689 tricellular tight junction(GO:0061689)
0.9 12.6 GO:0035686 sperm fibrous sheath(GO:0035686)
1.5 10.2 GO:0097452 GAIT complex(GO:0097452)
1.5 8.8 GO:0045179 apical cortex(GO:0045179)
0.0 7.8 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
1.3 7.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
2.1 6.3 GO:0005588 collagen type V trimer(GO:0005588)
0.8 6.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.7 6.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
1.2 5.9 GO:0030314 junctional membrane complex(GO:0030314)
1.9 5.7 GO:0034455 t-UTP complex(GO:0034455)
1.4 5.4 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 5.4 GO:0070160 occluding junction(GO:0070160)
1.7 5.2 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 5.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 4.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 4.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
1.0 3.9 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.4 3.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.1 24.3 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.8 15.0 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
3.2 12.6 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
2.9 11.5 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
3.4 10.2 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
1.1 10.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 9.8 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 9.5 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.2 8.8 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 8.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 7.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.6 6.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.4 6.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
2.1 6.2 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.3 5.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 5.9 GO:0005109 frizzled binding(GO:0005109)
1.4 5.4 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.2 5.3 GO:0004707 MAP kinase activity(GO:0004707)
1.2 4.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.4 4.7 GO:0022841 potassium ion leak channel activity(GO:0022841)