Motif ID: Hmx1

Z-value: 1.192


Transcription factors associated with Hmx1:

Gene SymbolEntrez IDGene Name
Hmx1 ENSMUSG00000067438.3 Hmx1



Activity profile for motif Hmx1.

activity profile for motif Hmx1


Sorted Z-values histogram for motif Hmx1

Sorted Z-values for motif Hmx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_147186389 23.640 ENSMUST00000109970.3
ENSMUST00000067075.5
Nkx2-2

NK2 homeobox 2

chr7_-_144939823 13.084 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr12_+_109459843 12.355 ENSMUST00000173812.1
Dlk1
delta-like 1 homolog (Drosophila)
chr6_+_30738044 10.269 ENSMUST00000128398.1
ENSMUST00000163949.2
ENSMUST00000124665.1
Mest


mesoderm specific transcript


chr7_-_48881032 9.939 ENSMUST00000058745.8
E2f8
E2F transcription factor 8
chr19_-_42202150 9.920 ENSMUST00000018966.7
Sfrp5
secreted frizzled-related sequence protein 5
chr17_-_71310952 9.735 ENSMUST00000024849.9
Emilin2
elastin microfibril interfacer 2
chr11_+_69965396 9.375 ENSMUST00000018713.6
Cldn7
claudin 7
chr2_+_168081004 9.173 ENSMUST00000052125.6
Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr18_+_74442551 7.664 ENSMUST00000121875.1
Myo5b
myosin VB
chr2_-_92370999 7.636 ENSMUST00000176810.1
ENSMUST00000090582.4
Gyltl1b

glycosyltransferase-like 1B

chr17_+_86963279 7.586 ENSMUST00000139344.1
Rhoq
ras homolog gene family, member Q
chr14_+_103070216 7.563 ENSMUST00000022721.6
Cln5
ceroid-lipofuscinosis, neuronal 5
chr6_-_127151044 6.960 ENSMUST00000000188.8
Ccnd2
cyclin D2
chr7_-_116308241 6.917 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
Plekha7


pleckstrin homology domain containing, family A member 7


chr6_-_95718800 6.909 ENSMUST00000079847.5
Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr1_+_52008210 6.651 ENSMUST00000027277.5
Stat4
signal transducer and activator of transcription 4
chr1_+_135729147 6.619 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr2_-_92371039 6.315 ENSMUST00000068586.6
Gyltl1b
glycosyltransferase-like 1B
chr10_-_77113676 6.262 ENSMUST00000072755.4
ENSMUST00000105409.1
Col18a1

collagen, type XVIII, alpha 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.9 23.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
1.4 20.0 GO:0035269 protein O-linked mannosylation(GO:0035269)
1.9 13.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
3.2 12.8 GO:0032439 endosome localization(GO:0032439)
0.4 12.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.7 12.2 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
1.1 11.4 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.6 10.1 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.4 10.0 GO:0010883 regulation of lipid storage(GO:0010883)
3.3 9.9 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
3.3 9.9 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
2.4 9.7 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.7 9.4 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.6 8.8 GO:0033327 Leydig cell differentiation(GO:0033327)
0.4 7.6 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
2.5 7.5 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.1 7.2 GO:0070527 platelet aggregation(GO:0070527)
0.1 7.0 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
1.2 6.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.8 6.9 GO:0006104 succinyl-CoA metabolic process(GO:0006104)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 24.7 GO:0005794 Golgi apparatus(GO:0005794)
0.4 20.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 19.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 18.0 GO:0005581 collagen trimer(GO:0005581)
2.1 12.8 GO:0045179 apical cortex(GO:0045179)
0.1 10.3 GO:0016528 sarcoplasm(GO:0016528)
0.6 9.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 9.2 GO:0016324 apical plasma membrane(GO:0016324)
0.2 7.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.9 7.6 GO:0005775 vacuolar lumen(GO:0005775)
0.5 7.5 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
1.2 6.9 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.6 6.9 GO:0005915 zonula adherens(GO:0005915)
0.0 6.8 GO:0005925 focal adhesion(GO:0005925)
0.0 6.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 6.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 6.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 5.4 GO:0005922 connexon complex(GO:0005922)
0.1 5.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 28.1 GO:0008134 transcription factor binding(GO:0008134)
0.1 24.7 GO:0005198 structural molecule activity(GO:0005198)
0.5 23.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
4.0 20.0 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.1 19.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 14.9 GO:0001047 core promoter binding(GO:0001047)
0.3 13.4 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.6 13.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 11.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 10.4 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 10.2 GO:0003777 microtubule motor activity(GO:0003777)
0.5 9.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.7 9.8 GO:0005537 mannose binding(GO:0005537)
2.4 9.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.3 9.3 GO:0043236 laminin binding(GO:0043236)
0.1 7.7 GO:0051015 actin filament binding(GO:0051015)
0.6 7.6 GO:0005522 profilin binding(GO:0005522)
0.6 6.9 GO:0034943 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.2 6.8 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 6.7 GO:0005509 calcium ion binding(GO:0005509)