Motif ID: Hmx2
Z-value: 0.491
Transcription factors associated with Hmx2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hmx2 | ENSMUSG00000050100.7 | Hmx2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hmx2 | mm10_v2_chr7_+_131548755_131548773 | 0.37 | 3.5e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.2 | GO:0060769 | positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) kidney smooth muscle tissue development(GO:0072194) negative regulation of dopaminergic neuron differentiation(GO:1904339) |
| 1.3 | 5.1 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 0.6 | 1.9 | GO:0035799 | ureter maturation(GO:0035799) cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536) |
| 0.6 | 1.8 | GO:0071603 | endothelial cell-cell adhesion(GO:0071603) |
| 0.6 | 1.8 | GO:0046544 | regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544) |
| 0.4 | 1.1 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.3 | 1.0 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.3 | 0.9 | GO:0045472 | response to ether(GO:0045472) |
| 0.3 | 2.0 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.2 | 0.9 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.2 | 0.9 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.2 | 1.0 | GO:0008611 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503) |
| 0.2 | 0.9 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.2 | 0.5 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.2 | 2.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 0.5 | GO:2001045 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.1 | 0.8 | GO:0098734 | protein depalmitoylation(GO:0002084) positive regulation of pinocytosis(GO:0048549) macromolecule depalmitoylation(GO:0098734) |
| 0.1 | 1.0 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.1 | 1.1 | GO:0046036 | GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036) |
| 0.1 | 0.6 | GO:0006528 | asparagine metabolic process(GO:0006528) |
| 0.1 | 0.7 | GO:0070814 | hydrogen sulfide biosynthetic process(GO:0070814) |
| 0.1 | 2.3 | GO:0021854 | hypothalamus development(GO:0021854) |
| 0.1 | 0.6 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.1 | 0.4 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.1 | 1.0 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.1 | 0.4 | GO:0051096 | positive regulation of helicase activity(GO:0051096) |
| 0.1 | 2.7 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
| 0.0 | 0.2 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.0 | 0.6 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 0.0 | 0.4 | GO:0006824 | cobalt ion transport(GO:0006824) |
| 0.0 | 0.2 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) |
| 0.0 | 0.2 | GO:2000680 | regulation of rubidium ion transport(GO:2000680) |
| 0.0 | 1.5 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 0.5 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.0 | 0.5 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.0 | 2.9 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 0.3 | GO:0010572 | positive regulation of platelet activation(GO:0010572) |
| 0.0 | 0.5 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.0 | 0.6 | GO:2000060 | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060) |
| 0.0 | 1.5 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 0.7 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 0.4 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.0 | 0.1 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.0 | 1.0 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.0 | 0.4 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 0.1 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.0 | 0.6 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.0 | 0.3 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.5 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 1.5 | GO:0006006 | glucose metabolic process(GO:0006006) |
| 0.0 | 0.3 | GO:1900273 | positive regulation of long-term synaptic potentiation(GO:1900273) |
| 0.0 | 0.5 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.0 | 0.1 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.0 | 0.3 | GO:0009303 | rRNA transcription(GO:0009303) |
| 0.0 | 1.3 | GO:0006997 | nucleus organization(GO:0006997) |
| 0.0 | 0.1 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540) |
| 0.3 | 0.8 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.2 | 0.7 | GO:0036156 | inner dynein arm(GO:0036156) |
| 0.2 | 0.9 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.2 | 1.5 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.2 | 1.0 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.1 | 0.5 | GO:0061702 | inflammasome complex(GO:0061702) |
| 0.1 | 0.9 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 1.3 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.1 | 0.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 1.2 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
| 0.1 | 0.6 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.1 | 0.5 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 0.6 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.1 | 0.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 0.2 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.0 | 0.5 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 1.4 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 1.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 1.5 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.6 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 1.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.3 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.0 | 0.4 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.0 | 6.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 2.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 4.0 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 1.1 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.2 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.9 | GO:0036126 | sperm flagellum(GO:0036126) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.1 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.4 | 1.9 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.3 | 1.6 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.3 | 2.0 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.2 | 0.9 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.2 | 0.5 | GO:0071862 | protein phosphatase type 1 activator activity(GO:0071862) |
| 0.2 | 0.9 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.1 | 1.0 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.1 | 1.0 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 1.0 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 0.1 | 0.5 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 0.8 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.1 | 0.4 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 1.2 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 0.3 | GO:0042806 | fucose binding(GO:0042806) |
| 0.1 | 0.2 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
| 0.1 | 1.0 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 1.0 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.1 | 2.7 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 1.8 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.6 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.1 | 1.1 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.1 | 0.3 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 0.8 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 0.4 | GO:0015087 | cobalt ion transmembrane transporter activity(GO:0015087) |
| 0.0 | 0.6 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.5 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.5 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 0.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.0 | 0.1 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.0 | 8.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.9 | GO:0050694 | galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.0 | 0.3 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.0 | 2.2 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.4 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 2.9 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 0.0 | 0.5 | GO:0003690 | double-stranded DNA binding(GO:0003690) |
| 0.0 | 0.5 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.1 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 1.5 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.0 | 0.3 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.8 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.1 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.0 | 2.8 | GO:0008022 | protein C-terminus binding(GO:0008022) |
