Motif ID: Hmx2

Z-value: 0.491


Transcription factors associated with Hmx2:

Gene SymbolEntrez IDGene Name
Hmx2 ENSMUSG00000050100.7 Hmx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx2mm10_v2_chr7_+_131548755_1315487730.373.5e-03Click!


Activity profile for motif Hmx2.

activity profile for motif Hmx2


Sorted Z-values histogram for motif Hmx2

Sorted Z-values for motif Hmx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 126 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48667508 5.050 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr5_-_28467093 4.244 ENSMUST00000002708.3
 Shh
sonic hedgehog
chr12_+_117843873 3.499 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr18_+_50051702 2.671 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr13_-_71963713 2.578 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr18_-_65939048 2.318 ENSMUST00000025396.3
 Rax
retina and anterior neural fold homeobox
chr19_-_58454435 2.237 ENSMUST00000169850.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr4_-_62470868 2.080 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
 Wdr31




WD repeat domain 31




chr14_+_73237891 2.015 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr2_-_9878580 1.881 ENSMUST00000102976.3
 Gata3
GATA binding protein 3
chr13_-_92794809 1.831 ENSMUST00000022213.7
 Thbs4
thrombospondin 4
chr5_+_23850590 1.805 ENSMUST00000181574.1
 2700038G22Rik
RIKEN cDNA 2700038G22 gene
chr11_-_100822525 1.778 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr2_-_24048857 1.740 ENSMUST00000114497.1
 Hnmt
histamine N-methyltransferase
chr4_+_147492417 1.600 ENSMUST00000105721.2
 Gm13152
predicted gene 13152
chr4_+_99955715 1.570 ENSMUST00000102783.4
 Pgm2
phosphoglucomutase 2
chr18_-_88894322 1.534 ENSMUST00000070116.5
ENSMUST00000125362.1
 Socs6

suppressor of cytokine signaling 6

chr6_+_29694204 1.501 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr18_+_4993795 1.435 ENSMUST00000153016.1
 Svil
supervillin
chr10_-_22149270 1.303 ENSMUST00000179054.1
ENSMUST00000069372.6
 E030030I06Rik

RIKEN cDNA E030030I06 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 5.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.4 4.2 GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) kidney smooth muscle tissue development(GO:0072194) negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0 2.9 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 2.7 GO:0032611 interleukin-1 beta production(GO:0032611)
0.1 2.3 GO:0021854 hypothalamus development(GO:0021854)
0.2 2.1 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3 2.0 GO:0001887 selenium compound metabolic process(GO:0001887)
0.6 1.9 GO:0035799 ureter maturation(GO:0035799) cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.6 1.8 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.6 1.8 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.0 1.5 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 1.5 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 1.5 GO:0006006 glucose metabolic process(GO:0006006)
0.0 1.3 GO:0006997 nucleus organization(GO:0006997)
0.4 1.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 1.1 GO:0046036 GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.3 1.0 GO:0015889 cobalamin transport(GO:0015889)
0.2 1.0 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.1 1.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 4.0 GO:0030426 growth cone(GO:0030426)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 1.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.5 GO:0001772 immunological synapse(GO:0001772)
0.0 1.4 GO:0043034 costamere(GO:0043034)
0.1 1.3 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 1.2 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 1.1 GO:0005902 microvillus(GO:0005902)
0.3 1.0 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 1.0 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 0.9 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.9 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.9 GO:0036126 sperm flagellum(GO:0036126)
0.3 0.8 GO:0042585 germinal vesicle(GO:0042585)
0.2 0.7 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.6 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.6 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.9 6.1 GO:0043237 laminin-1 binding(GO:0043237)
0.0 2.9 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 2.8 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 2.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 2.2 GO:0005178 integrin binding(GO:0005178)
0.3 2.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.4 1.9 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 1.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 1.6 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 1.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 1.2 GO:0005537 mannose binding(GO:0005537)
0.1 1.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 1.0 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 1.0 GO:0031419 cobalamin binding(GO:0031419)
0.1 1.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 1.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 0.9 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 0.9 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)