Motif ID: Hmx3

Z-value: 0.303


Transcription factors associated with Hmx3:

Gene SymbolEntrez IDGene Name
Hmx3 ENSMUSG00000040148.5 Hmx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx3mm10_v2_chr7_+_131542867_1315428670.162.2e-01Click!


Activity profile for motif Hmx3.

activity profile for motif Hmx3


Sorted Z-values histogram for motif Hmx3

Sorted Z-values for motif Hmx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_86548268 1.178 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr1_-_78968079 0.934 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr1_-_175979114 0.885 ENSMUST00000104983.1
 B020018G12Rik
RIKEN cDNA B020018G12 gene
chr3_-_154328634 0.867 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr4_-_45532470 0.858 ENSMUST00000147448.1
 Shb
src homology 2 domain-containing transforming protein B
chr2_+_3114220 0.785 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr5_+_15516489 0.771 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr13_+_118714678 0.721 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr4_-_129261394 0.689 ENSMUST00000145261.1
 C77080
expressed sequence C77080
chr5_-_53707532 0.674 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr10_+_99263224 0.672 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr18_+_61639542 0.576 ENSMUST00000183083.1
ENSMUST00000183087.1
 Gm20748

predicted gene, 20748

chr7_-_30559828 0.541 ENSMUST00000108164.1
 Lin37
lin-37 homolog (C. elegans)
chr7_+_3645267 0.517 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr7_-_30559600 0.483 ENSMUST00000043975.4
ENSMUST00000156241.1
 Lin37

lin-37 homolog (C. elegans)

chr11_+_103133303 0.475 ENSMUST00000107037.1
 Hexim2
hexamethylene bis-acetamide inducible 2
chr3_+_96629919 0.459 ENSMUST00000048915.6
 Rbm8a
RNA binding motif protein 8a
chr5_-_87482258 0.441 ENSMUST00000079811.6
ENSMUST00000144144.1
 Ugt2a1

UDP glucuronosyltransferase 2 family, polypeptide A1

chr3_-_49757257 0.436 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chrM_+_9452 0.434 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chrX_+_150594420 0.428 ENSMUST00000112713.2
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr12_-_83487708 0.425 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr11_+_114668524 0.415 ENSMUST00000106602.3
ENSMUST00000077915.3
ENSMUST00000106599.1
ENSMUST00000082092.4
 Rpl38



ribosomal protein L38



chr19_+_41933464 0.396 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr9_+_21955747 0.374 ENSMUST00000053583.5
 Swsap1
SWIM type zinc finger 7 associated protein 1
chr4_+_65604984 0.352 ENSMUST00000050850.7
ENSMUST00000107366.1
 Trim32

tripartite motif-containing 32

chr10_-_80421847 0.342 ENSMUST00000156244.1
 Tcf3
transcription factor 3
chr11_+_103133333 0.331 ENSMUST00000124928.1
ENSMUST00000062530.4
 Hexim2

hexamethylene bis-acetamide inducible 2

chr19_+_8802486 0.329 ENSMUST00000172175.1
 Zbtb3
zinc finger and BTB domain containing 3
chr1_-_158814469 0.322 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr5_+_121777929 0.319 ENSMUST00000160821.1
 Atxn2
ataxin 2
chr7_-_127208423 0.302 ENSMUST00000120705.1
 Tbc1d10b
TBC1 domain family, member 10b
chr2_-_153015331 0.299 ENSMUST00000028972.8
 Pdrg1
p53 and DNA damage regulated 1
chr6_+_86371489 0.294 ENSMUST00000089558.5
 Snrpg
small nuclear ribonucleoprotein polypeptide G
chr7_-_126897424 0.291 ENSMUST00000120007.1
 Tmem219
transmembrane protein 219
chr8_-_23237623 0.275 ENSMUST00000033950.5
 Gins4
GINS complex subunit 4 (Sld5 homolog)
chr17_-_35697971 0.262 ENSMUST00000146472.1
 Ddr1
discoidin domain receptor family, member 1
chr7_+_43690418 0.253 ENSMUST00000056329.6
 Klk14
kallikrein related-peptidase 14
chr17_-_57247632 0.252 ENSMUST00000005975.6
 Gpr108
G protein-coupled receptor 108
chrX_-_60893430 0.244 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr2_-_72986716 0.241 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr9_-_123678782 0.226 ENSMUST00000170591.1
ENSMUST00000171647.1
 Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr2_-_84715160 0.170 ENSMUST00000035840.5
 Zdhhc5
zinc finger, DHHC domain containing 5
chr14_+_54464141 0.164 ENSMUST00000022782.8
 Lrp10
low-density lipoprotein receptor-related protein 10
chr19_-_41933276 0.162 ENSMUST00000075280.4
ENSMUST00000112123.2
 Exosc1

exosome component 1

chr11_+_69838514 0.121 ENSMUST00000133967.1
ENSMUST00000094065.4
 Tmem256

transmembrane protein 256

chr12_-_108179210 0.116 ENSMUST00000125916.2
ENSMUST00000109879.1
 Setd3

SET domain containing 3

chr12_+_108179738 0.108 ENSMUST00000101055.4
 Ccnk
cyclin K
chr12_-_108179237 0.108 ENSMUST00000071095.7
 Setd3
SET domain containing 3
chr5_-_137684665 0.096 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
 Agfg2


ArfGAP with FG repeats 2


chr13_+_23746734 0.095 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr7_-_45510400 0.092 ENSMUST00000033096.7
 Nucb1
nucleobindin 1
chr13_-_92131494 0.088 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr9_-_123678873 0.079 ENSMUST00000040960.6
 Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr15_-_13173607 0.078 ENSMUST00000036439.4
 Cdh6
cadherin 6
chr4_+_134397380 0.074 ENSMUST00000105870.1
 Pafah2
platelet-activating factor acetylhydrolase 2
chrX_+_159708593 0.048 ENSMUST00000080394.6
 Sh3kbp1
SH3-domain kinase binding protein 1
chr7_+_25681158 0.048 ENSMUST00000108403.3
 B9d2
B9 protein domain 2
chr2_-_130424673 0.004 ENSMUST00000110277.1
 Pced1a
PC-esterase domain containing 1A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0071336 lung growth(GO:0060437) positive regulation of fat cell proliferation(GO:0070346) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.2 0.7 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.2 0.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.9 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.4 GO:1903265 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172) positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.4 GO:0048318 axial mesoderm development(GO:0048318)
0.1 0.3 GO:0002326 B cell lineage commitment(GO:0002326)
0.1 0.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.3 GO:0036233 glycine import(GO:0036233)
0.0 1.2 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.3 GO:0007320 insemination(GO:0007320)
0.0 0.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.8 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.9 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.2 GO:0007530 sex determination(GO:0007530)
0.0 0.4 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.4 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.3 GO:0000811 GINS complex(GO:0000811)
0.0 0.3 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.1 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.4 GO:0071565 nBAF complex(GO:0071565)
0.0 0.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.8 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.3 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.6 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.7 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)