Motif ID: Hnf1a

Z-value: 0.606


Transcription factors associated with Hnf1a:

Gene SymbolEntrez IDGene Name
Hnf1a ENSMUSG00000029556.6 Hnf1a



Activity profile for motif Hnf1a.

activity profile for motif Hnf1a


Sorted Z-values histogram for motif Hnf1a

Sorted Z-values for motif Hnf1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf1a

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_144751968 5.762 ENSMUST00000155175.1
 Ano1
anoctamin 1, calcium activated chloride channel
chr9_-_106158109 5.079 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
 Glyctk



glycerate kinase



chr19_-_14598031 3.666 ENSMUST00000167776.2
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr19_-_14597983 3.389 ENSMUST00000052011.7
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr13_-_53286052 3.333 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr2_-_68472138 2.830 ENSMUST00000102715.3
 Stk39
serine/threonine kinase 39
chr9_+_99629496 2.500 ENSMUST00000131095.1
ENSMUST00000078367.5
ENSMUST00000112885.2
 Dzip1l


DAZ interacting protein 1-like


chr19_-_47919269 2.311 ENSMUST00000095998.5
 Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr9_+_57827284 2.259 ENSMUST00000163186.1
 Gm17231
predicted gene 17231
chr11_-_11898044 2.055 ENSMUST00000066237.3
 Ddc
dopa decarboxylase
chr7_-_79842287 2.050 ENSMUST00000049004.6
 Anpep
alanyl (membrane) aminopeptidase
chr11_-_11898092 1.961 ENSMUST00000178704.1
 Ddc
dopa decarboxylase
chr2_+_110597298 1.945 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr7_+_141215852 1.917 ENSMUST00000046890.5
ENSMUST00000133763.1
 Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr11_+_78178105 1.861 ENSMUST00000147819.1
 Tlcd1
TLC domain containing 1
chr7_+_75610038 1.764 ENSMUST00000125771.1
 Akap13
A kinase (PRKA) anchor protein 13
chr5_+_8046077 1.759 ENSMUST00000088786.4
 Sri
sorcin
chr9_+_99629823 1.666 ENSMUST00000112886.2
 Dzip1l
DAZ interacting protein 1-like
chr16_+_20651652 1.641 ENSMUST00000007212.8
 Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr11_+_3983636 1.615 ENSMUST00000078757.1
 Gal3st1
galactose-3-O-sulfotransferase 1
chr5_+_24428208 1.569 ENSMUST00000115049.2
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr10_+_87859255 1.465 ENSMUST00000105300.2
 Igf1
insulin-like growth factor 1
chr11_+_3983704 1.432 ENSMUST00000063004.7
 Gal3st1
galactose-3-O-sulfotransferase 1
chr6_+_29859374 1.425 ENSMUST00000115238.3
 Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr17_+_71204647 1.353 ENSMUST00000126681.1
 Lpin2
lipin 2
chr10_+_87859062 1.341 ENSMUST00000095360.4
 Igf1
insulin-like growth factor 1
chr15_-_42676967 1.330 ENSMUST00000022921.5
 Angpt1
angiopoietin 1
chr19_+_42045792 1.319 ENSMUST00000172244.1
ENSMUST00000081714.4
 Hoga1

4-hydroxy-2-oxoglutarate aldolase 1

chr6_+_29859662 1.263 ENSMUST00000128927.2
 Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr6_+_29859686 1.229 ENSMUST00000134438.1
 Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr1_+_172698046 1.205 ENSMUST00000038495.3
 Crp
C-reactive protein, pentraxin-related
chr9_+_53771499 1.195 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr6_+_38918969 1.193 ENSMUST00000003017.6
 Tbxas1
thromboxane A synthase 1, platelet
chr7_+_141216626 1.165 ENSMUST00000141804.1
ENSMUST00000148975.1
 Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr14_+_79515618 1.133 ENSMUST00000110835.1
 Elf1
E74-like factor 1
chr4_+_11758147 1.039 ENSMUST00000029871.5
ENSMUST00000108303.1
 Cdh17

cadherin 17

chr19_+_6105774 0.911 ENSMUST00000044451.3
 Naaladl1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr3_-_122984404 0.870 ENSMUST00000090379.2
 Usp53
ubiquitin specific peptidase 53
chr17_-_35132050 0.856 ENSMUST00000025249.6
 Apom
apolipoprotein M
chr3_+_90537242 0.852 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chrX_+_101377267 0.843 ENSMUST00000052130.7
 Gjb1
gap junction protein, beta 1
chr3_+_90537306 0.788 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr9_-_71163224 0.733 ENSMUST00000074465.2
 Aqp9
aquaporin 9
chr10_-_30842765 0.664 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr4_+_150853919 0.614 ENSMUST00000073600.2
 Errfi1
ERBB receptor feedback inhibitor 1
chr7_+_140763739 0.542 ENSMUST00000026552.7
 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr5_-_114444036 0.528 ENSMUST00000031560.7
 Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr10_-_76110956 0.482 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr15_-_79285502 0.417 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr2_-_155357392 0.365 ENSMUST00000165234.1
ENSMUST00000077626.6
 Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chrX_+_101376359 0.234 ENSMUST00000119080.1
 Gjb1
gap junction protein, beta 1
chr4_-_97778042 0.204 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr5_-_114443993 0.121 ENSMUST00000112245.1
 Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr18_-_6516089 0.112 ENSMUST00000115870.2
 Epc1
enhancer of polycomb homolog 1 (Drosophila)
chr7_-_119895446 0.101 ENSMUST00000098080.2
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr13_+_83738874 0.099 ENSMUST00000052354.4
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr10_+_63061582 0.093 ENSMUST00000020266.8
ENSMUST00000178684.1
 Pbld1

phenazine biosynthesis-like protein domain containing 1

chr7_-_45062393 0.051 ENSMUST00000129101.1
 Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr9_+_109096659 0.042 ENSMUST00000130366.1
 Plxnb1
plexin B1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.8 GO:0015705 iodide transport(GO:0015705)
1.0 3.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.9 2.8 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.9 2.8 GO:1904192 cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.7 4.0 GO:0098700 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.7 3.3 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.5 3.9 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.4 1.3 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.3 1.0 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.3 1.3 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.3 1.2 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.3 1.8 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.3 1.8 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.2 0.7 GO:0003195 tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.2 0.9 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.2 0.6 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.2 1.2 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 2.1 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.1 1.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.1 0.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.7 GO:0032782 urea transport(GO:0015840) bile acid secretion(GO:0032782) urea transmembrane transport(GO:0071918)
0.1 0.5 GO:0035428 hexose transmembrane transport(GO:0035428)
0.1 1.1 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 2.3 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1 0.4 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 1.6 GO:0051592 response to calcium ion(GO:0051592)
0.0 1.4 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.5 GO:0017144 drug metabolic process(GO:0017144)
0.0 0.1 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 1.6 GO:0006821 chloride transport(GO:0006821)
0.0 4.2 GO:0042384 cilium assembly(GO:0042384)
0.0 0.0 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 1.9 GO:0006814 sodium ion transport(GO:0006814)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.7 2.1 GO:0031983 vesicle lumen(GO:0031983)
0.6 1.8 GO:0042584 chromaffin granule membrane(GO:0042584)
0.2 0.9 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 5.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.1 1.1 GO:0005922 connexon complex(GO:0005922)
0.1 0.4 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 4.2 GO:0005814 centriole(GO:0005814)
0.0 0.7 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 4.0 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.3 GO:0005902 microvillus(GO:0005902)
0.0 6.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.2 GO:0030175 filopodium(GO:0030175)
0.0 3.6 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.8 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
1.0 4.0 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.8 3.0 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.6 3.9 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.5 1.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.3 1.0 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.3 1.3 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.2 1.2 GO:0001849 complement component C1q binding(GO:0001849)
0.2 0.7 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.7 GO:0015265 urea channel activity(GO:0015265)
0.1 2.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 1.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 8.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 0.5 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 2.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 3.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 1.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 1.1 GO:0005243 gap junction channel activity(GO:0005243)
0.1 1.6 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 0.4 GO:0034235 GPI anchor binding(GO:0034235)
0.1 0.9 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.5 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 1.2 GO:0004497 monooxygenase activity(GO:0004497)
0.0 2.8 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 2.3 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.0 0.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.9 GO:0016209 antioxidant activity(GO:0016209)